Kurt zimmerman

Kidney macrophage and T cell biologist studying polycystic kidney disease @ouhscN husband, dad, sports lover (braves badgers packers 🧀)

[Kurt zimmerman @Zimmermk1986]

@Carmendemigue12 @JCI_insight Thank you!

[Kurt zimmerman @Zimmermk1986]

Excited to share the most recent work from our lab! If you are a pkd researcher, check out our website to investigate expression of your gene in different cell types/models!

[JCI insight @JCI_insight]

Kurt A. Zimmerman @Zimmermk1986 developed a single-cell atlas of polycystic kidney disease (#PKD) that integrates multiple disease models: https://t.co/GXA5x7eb7m
The authors then used the atlas to identify increased osteopontin (Spp1) as a common factor in PKD. Spp1 deletion in PKD mouse models reduced cyst severity and improved kidney function. Importantly, the atlas can be accessed at: https://t.co/exeRyWXJZf
@yoderlab_uab @KatharinaHopp85 @daniyal_jafree @UCL_ICH_Kidney

[JCI insight @JCI_insight]

Kurt A. Zimmerman @Zimmermk1986 developed a single-cell atlas of polycystic kidney disease (#PKD) that integrates multiple disease models: https://t.co/GXA5x7eb7m
The authors then used the atlas to identify increased osteopontin (Spp1) as a common factor in PKD. Spp1 deletion in PKD mouse models reduced cyst severity and improved kidney function. Importantly, the atlas can be accessed at: https://t.co/exeRyWXJZf
@yoderlab_uab @KatharinaHopp85 @daniyal_jafree @UCL_ICH_Kidney

[Jamie Privratsky MD/PhD @JamiePrivratsky]

Check out my lab’s new paper in @JCI_insight - The myeloid IL-1 receptor limits IL-27-mediated endothelial type I IFN during nephrotoxic serum nephritis https://t.co/AVt3hxG7v0 @Duke_Anesthesia @DukeKidney @Yanting17931824 @the_asci

[Waggoner Lab @LabWaggoner]

Macrophages are what they eat
Macrophages transfer functional proteins to their surface during live-cell uptake
https://t.co/kMdlX5foU9 @nchembio @UCSF @ReganVolk https://t.co/D7wYAudRsN

[AJP Renal @AJPRenal]

We're looking at the progress from #AKI to #CKD in this @YaleMed research article, VCAM-1 mediates proximal tubule-immune cell cross talk in failed tubule #recovery during AKI-to-CKD transition (Isabel Melchinger et al.):

https://t.co/YrsgKAIhnm

[Journal of Clinical Investigation @jclinicalinvest]

Early signals shape cardiac macrophage phenotypes and repair outcomes: https://t.co/11XS63H4NX
Andrew Koenig @Koenig_Cardio, @junedh_amrute et al. @LavineLab @washumedicine traced monocyte differentiation trajectories after injury and identified an MHCIIhi population with an early IFN response signature associated with enhanced #Cardioprotection.

The image shows activation of a type I IFN response (green) in CCR+ extravasating monocytes (red) in a mouse heart 24 hours after transplantation.
@the_asci
#MyocardialInfarction

[Daniyal Jafree @daniyal_jafree]

🚨 New paper in @jclinicalinvest!

Kidney lymphatics are a promising target in transplant rejection

🗺️ In rejection, lymphatics expand and adversely remodel

⚡️ Although they have an anti-inflammatory profile, they are attacked by the immune system

https://t.co/Hki81lmvLp

1/4

[PKD Research Resource Consortium @PkdResearch]

The University of Kansas Medical Center is pleased to announce the 2026 Jared J. Grantham Symposium: The Future of PKD Research, taking place September 18, 2026. See Registration Link: https://t.co/WFO2OGiNYE

[Eyo @eyolab]

Fascinating new findings suggesting through epigenetic assessments that human microglia are replaced by infiltrating monocytes in aging challenging the notion that yolk-sac derived microglia are maintained without infiltration throughout (human) life. 🤯https://t.co/XXUHGtKKe1

[Kurt zimmerman @Zimmermk1986]

@rampagepoker $1878

[Tarek M. Ashkar (El-Achkar) @AshkarLab]

I am honored to be on the ballot for @ASNKidney Councilor at large. Truly thankful to all the support and encouragement!

[Matthias Nahrendorf @MatthiasNahrend]

cool paper alert
👇
https://t.co/EPhPDJ6lwp

[John Lukens @LukensJohnR]

C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brain @ScienceMagazine https://t.co/OZoKApeIeF

[Science Immunology @SciImmunology]

A new approach combines fluorescent labels and single-cell RNA sequencing to analyze transcriptional changes after #efferocytosis of tumor cells in #macrophages.

Learn more in Science #Immunology: https://t.co/k2vCAZFtgz

[Ayshwarya Subramanian @ayshwaryas]

My group is hiring a postdoc at the intersection of #AI and #genomics funded by @BezosEarthFund : https://t.co/RIJ3GsZtao
Please share with comp biologists, ML researchers, genome scientists, and conservation genomics trainees excited to use AI to help protect biodiversity.

[Dr. Helen E. Collins @DrHelenECollin1]

Single nuclear RNA-seq analyses of human HFpEF published in @CircRes https://t.co/NHkr9H3UCd

[ᒍOᕼᗩᑎ ᗪᑌᑕᕼEᑎE @DucheneJohan]

TREM2+ macrophages have rapidly emerged as key regulators in diseases.

Studying them requires specific antibodies.

Among 14 tested antibodies in KO cell lines, 5 are specific in WB.

Pick up the right one.

Full report: https://t.co/ypWzdLziaP
Or here: https://t.co/VYEheOoOKP

[Roman-Ulrich Müller @MuellerRom]

I usually think twice before posting preprints. But this time it’s different.
MEDA-PKD is the essence of our work over more than a decade — and, to me, one of the most meaningful contributions I’ve been able to make to biomedical research.
🧵

[Hao Yin @HaoYin20]

NicheNet v2
https://t.co/4EV78w4JyU

Resolve cell-cell communications with ~5k ligand-receptor pairs
Account for DEG in receiver cells
Sender/ligand-agnostic + Sender-focused approach

A step-by-step protocol😎

@YvanSaeys @NatureProtocols 2025
https://t.co/A3RlYkngcD