Zu-Hang Sheng

A neuroscientist at NINDS/NIH studying neuronal mitochondria/lysosomes and energy metabolism. Opinions are my own.

[Zu-Hang Sheng @zuhangsheng]

Excited to share our latest work, now published in Neuron: we uncover how age-associated oxidative stress remodels mitochondrial nucleoid architecture by disrupting TFAM–mtDNA organization, impairing mitochondrial gene expression and bioenergetic function in aging neurons.

[Neuron @NeuroCellPress]

Online now: Redox-dependent remodeling of mitochondrial nucleoids contributes to bioenergetic decline during neuronal aging dlvr.​it/TW9t3M

[Zu-Hang Sheng @zuhangsheng]

Pleased to share our invited News & Views piece in @NatMetabolism, highlighting the emerging role of lipid metabolism in fueling synaptic transmission. Grateful to @sunan_li for co-authoring this contribution with me.

[Nature Metabolism @NatMetabolism]

Fuelling synapses via lipid metabolism https://t.co/5G7yVky2OH

[Zu-Hang Sheng @zuhangsheng]

We are delighted that our recent review has been included in the JCB Cellular Neurobiology 2024 Special Collection.

[Journal of Cell Biology @JCellBiol]

Xiong and @zuhangsheng review recent advances in presynaptic mechanisms of neurodevelopmental disorders by focusing on impaired axonal transport of presynaptic cargos.

📙 In our Cellular Neurobiology collection: https://t.co/bWdXID0WPu

#SfN24 #Neuroscience

[Zu-Hang Sheng @zuhangsheng]

thrilled to share our latest review discussing presynaptic perspectives of neurodevelopmental disorders by focusing on impaired axonal transport and disturbed assembly and maintenance of presynapses. https://t.co/6BlZunho1G

[Journal of Cell Biology @JCellBiol]

Presynaptic perspective: Axonal transport defects in neurodevelopmental disorders. New review from Gui-Jing Xiong and Zu-Hang Sheng (@zuhangsheng) @NIH_NINDS: https://t.co/XwNxKArSf9

#Trafficking #Neuroscience

[Zu-Hang Sheng @zuhangsheng]

Delighted to share our review. Congrats to Gui-Jing Xiong! Thank JCB editor @andrea_marat for handling this review so well, and the reviewers who provided constructive comments. Very happy to publish with @JCellBiol.

[Journal of Cell Biology @JCellBiol]

New review: Xiong and Sheng @zuhangsheng @NIH_NINDS summarize recent advances in presynaptic mechanisms of neurodevelopmental disorders by focusing on impaired axonal transport of presynaptic cargos. https://t.co/jvx0oAweZT

#Trafficking #Neuroscience

[Zu-Hang Sheng @zuhangsheng]

Really Fun visiting UNC Chapel Hill and meeting faculty and graduate students in Department of Pharmacology. Many thanks to Juan Song @Songlaboratory for hosting. It was great hearing about all of exciting research form the Song Lab and others!

[Juan Song @Songlaboratory]

My great pleasure to host Dr. Zuhang Sheng @zuhangsheng from NIH for an inspiring seminar on mitochondrial reprogramming and energy metabolism for neuroregeneration @UNC_PHCO.

[Zu-Hang Sheng @zuhangsheng]

@Songlaboratory @UNC_PHCO Really Fun visiting UNC Chapel Hill and meeting faculty and graduate students in the Department of Pharmacology @UNC_PHCO. Many thanks to Juan Song @Songlaboratory for hosting. It was great hearing about all of exciting research form the Song Lab and others!

[Zu-Hang Sheng @zuhangsheng]

I am shocked and saddened to learn of the passing of Bill Catterall, my postdoc mentor and a pioneer and giant in ion channel research. It is a great loss for science.

[NIHOxCam @NIHOxCam]

Thrilled to share that #NIHOxCam scholar @aditi_k37 recently passed her First Year Report!! Aditi is co-mentored by @zuhangsheng in the NINDS and @LakatosLab at @Cambridge_Uni. Way to go Aditi 🎉

[Zu-Hang Sheng @zuhangsheng]

Delighted to share our review led by @sunan_li and invited by co-editors @inna_slutsky and RH Swerdlow. We overview recent advances in how oligodendrocytes support axonal energy metabolism in health and neurological disorders. https://t.co/co7i1MoisA

[Cell Biology J-Club @cell_club]

TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport
https://t.co/gp9LKVT3LK

[Journal of Cell Biology @JCellBiol]

.@zuhangsheng et al review how axonal endolysosomal trafficking, distribution, and lysosomal functionality support neuronal health & become disrupted in several neurodegenerative diseases https://t.co/6791lyC43s

From our Cellular Neurobiology 2022: https://t.co/a6QDruCFwb #SfN22

[Alessio Vagnoni - now @alessiovagnoni.bsky.social @alessio_vagnoni]

...including an intriguing role for Syntaphilin in reducing Split-Miro-dependent fly hyperactivity @zuhangsheng. The use of the LOV2/Zdk1 module was inspired by the beautiful work of @JeffreyHaren @WittmannTorsten and colleagues on EB1.
9/10

[M W @Michael_E_Ward_]

We have liftoff! Great overviews of the official launch of the iPSC Neurodegenerative Disease Initiative (iNDI). Large-scale, NIH-funded resource of genetically-engineered isogenic iPSC lines harboring neurodegeneration-related mutations.

https://t.co/recqVO9AVl

[Zu-Hang Sheng @zuhangsheng]

Congratulations to Sunan @sunan_li for winning NINDS Image Contest.

[Zu-Hang Sheng @zuhangsheng]

Thanks to a great collaborative effort with Neuron editors @NeuroCellPress, and @XiutangC, @nigg_huang. The maintenance of axonal mitochondria & energy metabolism is one of the most interesting topics to power neuronal survival, function, & regeneration.

[Neuron @NeuroCellPress]

In this issue's free featured #Review by @XiutangC, @nigg_huang & @zuhangsheng, learn how neurons maintain axonal mitochondria & about potential strategies that target bioenergetic restoration to power neuronal survival, function, & regeneration.
https://t.co/ts0wYYJmpe

[Zu-Hang Sheng @zuhangsheng]

@WormlockHolmes Thank you Sandhya!

[Zu-Hang Sheng @zuhangsheng]

Happy to share a featured review out in the new issue @NeuroCellPress on Programming axonal mitochondrial maintenance and bioenergetics in neurodegeneration and regeneration. Congrats to @XiutangC, @nigg_huan, and the Sheng Lab: https://t.co/B8A9IqcOD7. https://t.co/CH7uSYN1nT

[Zu-Hang Sheng @zuhangsheng]

@scrippsresearch Fantastic! Congratulations Sandra @EncaladaLab

[Zu-Hang Sheng @zuhangsheng]

@EncaladaLab Thank you Sandra!

[Zu-Hang Sheng @zuhangsheng]

I am grateful to be one of the highlights in the NINDS Director’s post on the celebration of Asian American, Native Hawaiian, and Pacific Islander Heritage Month 2022.