4Dcell

Smart control of the cell microenvironment - Bioengineered in vitro assays

[Sarah Guest @Sarahmoeba]

Vahlkampfia amoebae crawling through 6μm microchannels from @4DCell yesterday in an impromptu imaging session with @KatrinaVelle

[4Dcell @4Dcell]

Sometimes a client will ask a question and we will find out that our wonderful clients have already provided the answer! Case in point: yes, you can combine the @4Dcell confiner with micropatterns 🤩

[Logue Lab @JeremyLogue1]

We've added important new data to our recent pre-print (https://t.co/KdwcHT6Y2a). While cells in confinement without INF2 firmly adhere to the micropattern, cells with INF2 will cross over the micropatterns using fast amoeboid (leader bleb-based) migration:

[Logue Lab @JeremyLogue1]

We've added important new data to our recent pre-print (https://t.co/KdwcHT6Y2a). While cells in confinement without INF2 firmly adhere to the micropattern, cells with INF2 will cross over the micropatterns using fast amoeboid (leader bleb-based) migration:

[4Dcell @4Dcell]

Come and do your PhD with us in collaboration with Institut Curie!

[4Dcell @4Dcell]

We've updated our page of client publications, soon we won't be able to keep up! Seeing all the beautiful images makes us so happy. Did we miss yours?
https://t.co/evlzZ1ZQQP

[4Dcell @4Dcell]

Beautiful study!!! We love to see what our clients do with our devices 🤩😍🤩

[J Cell Science @J_Cell_Sci]

Connie Shen @peepingcells, @MandlLab @mcgillu, @Vrisekoop @UMCUtrecht and colleagues discover that nuclear segmentation allows neutrophils to migrate faster in confined spaces.
Highlight: https://t.co/pYxP4oEofJ
Report: https://t.co/RvCDk25qPQ
#OpenAccess #ReadandPublish

[Mandl Lab @MandlLab]

Why do neutrophils have multi-lobed nuclei? 🧐

Does this enable their rapid migration through tight spaces? 🏃‍♀️💨

In this study, we sought to answer this question experimentally 🔬

Here is what we found 👇

[4Dcell @4Dcell]

You've seen our beating cardiomyocyte rings and you want to know more? Check out our publication in @eLife , fresh off the press! #organInaWell #cardiacRing @DrHulot_PARCC https://t.co/Mi6AZPzoTO

[GRRC -French community in cardiovascular research @GRRC_SFCardio]

C'est aujourd'hui le grand jour ! Notre Printemps de la Cardiologie 2023 commence cet après-midi à Marseille. Nous vous donnons rendez-vous à la Timone
https://t.co/73eCAmjIpQ
@JeremyFauconni1 @DrHulot_PARCC @RA_GRRC

[4Dcell @4Dcell]

Are you in Marseilles for the Printemps de la Cardiologue? So are we! Looking forward to some intriguing talks, especially from our collaborator @DrHulot_PARCC. Come and see us to learn more about our smartheart assay! 💚 @GRRC_SFCardio

[4Dcell @4Dcell]

Sometimes we miss one of our clients' publications because of a typo, which is too bad because they do cool stuff! Check out these dynamic micropatterns made with light-responsive azopolymers and our micropatterning kit 🤩 https://t.co/uJrMeyokFh

[4Dcell @4Dcell]

We're always happy to see what our clients do with our products, even if sometimes it's quite... unexpected! @skglasser what were you trying to see?

[Katrina Velle @KatrinaVelle]

Happy #MicroscopyMonday!
This was an experiment I did not expect today, but I had a great time working with @skglasser (of the Adler lab @Science_Poetry) to test flattening bumblebee intestine in the @4Dcell confiner!

LUT: yellow hot

[4Dcell @4Dcell]

Are you interested in a complete vascularized tumor microenvironment? Tumor cells+fibroblasts, under a perfused epithelium, in a convenient 24WP format. Come to booth 1354 or to @CherryBiotech 's poster at the @AACR meeting to find out more! #AACR23
https://t.co/o9LslzlyRp

[Katrina Velle @KatrinaVelle]

Happy #MicroscopyMonday!
here is a ~very~ blebby amoeba crawling along a microchannel.

[4Dcell @4Dcell]

Beautiful work Shiraishi et al! They show that alveolar cells plated on 10 um upatterns don't spread and retain their AT2 differentiation, unlike cells plated on larger upatterns. Actin accumulation around the nucleus and yap/taz localization also depend on upattern size🤩

[Cell @CellCellPress]

Now online! Biophysical forces mediated by respiration maintain lung alveolar epithelial cell fate https://t.co/bv4RCYiYVa

[4Dcell @4Dcell]

😍

[Katrina Velle @KatrinaVelle]

Happy #MicroscopyMonday!
Here is an amoeba crawling through a microchannel (from @4Dcell). Blue areas show where the cell is in close contact with the coverslip (imaged by IRM), and DIC is shown in grayscale.

[4Dcell @4Dcell]

Are you interested in learning more about the business side of Science? Come participate in this course, and find out how 4Dcell was created!

[Zymvol Biomodeling @zymvol]

🙋Hey, #ScienceStudents! Not a fan of filling tubes in the lab or getting muddy in the field⛈?

💡 Looking to upgrade your #computing and #business skills?

We’ll help you find your way in our 1-week course 👇

🔗 More Info: https://t.co/uzLUz2yuvp

@bligzymes @BioInspSensing

[4Dcell @4Dcell]

😍

[Katrina Velle @KatrinaVelle]

For night 18 of #31NightsOfHalloween #MicrosCreepy, here is a cell's worst nightmare: getting squished under a pillar in a cell confinement (torture) chamber!

[4Dcell @4Dcell]

It's always so nice to see our products in action! Beautiful videos @KatrinaVelle ! #cellmigration #3dcellculture

[Katrina Velle @KatrinaVelle]

Happy #MicroscopyMonday!
I've been using microchannels made by @4Dcell to explore how amoebae crawl in confinement. I think these cells are happy with their new playground.

[4Dcell @4Dcell]

Lovely experiments performed with a cell confiner!

[eLife - the journal @eLife]

How does cell volume respond as cell shape changes? https://t.co/S4ZQSCVL3r