LIDAR sees the light!
Please have a look at the latest (and my first as a postdoc) preprint from the Bonasio lab.
Do you think there are RNAs out there that we haven’t cloned yet? You are not alone.
https://t.co/2NK7cBK6Ze
We find no evidence that the formation of "transcriptional condensates" amplifies gene expression or increases transcription activation https://t.co/gzjEKlfvaF
"At its best, science is a self-correcting march toward greater knowledge for the betterment of humanity. At its worst, it is a self-interested pursuit of greater prestige at the cost of truth and rigor." hear, hear!
🚨I wrote the Atlantic’s next cover story on the COVIDization of science. No other disease has been scrutinized so intensely, by so much combined intellect, in so brief a time. This piece is about both the victories achieved & the weaknesses exposed. 1/
https://t.co/RbL9mVHhEv
Nice reflection on the protein folding breakthrough. Even if you don't care too much about the technicalities, there are some intriguing thoughts about how science progresses inside and outside of academia in the last two paragraphs
@TanentzapfLab You are not wrong, but the crux is to get a career (PI position) in the first place. Yes, I know many that got there without CNS papers, but it is an uphill battle.
We have had encouraging discussions in our @IJMonod forum about prioritizing not-for-profit publishing, and not being enraptured by NPG and Elsevier for our labs and for our recruitment. If this is in line with your philosophy I encourage you to apply to join us!
If you download the raw ChIP-seq data from a high profile paper there's usually about a 50% chance that it just looks like sonicated DNA. Mapped data from a Science paper today and there was just no enrichment anywhere. A giveaway is when there are no tracks shown in the paper.
@OMarshall_lab @SethCheetham Yes, that is also why the "complete story" scam works so well. You have genomics, behavior, cell biology et al. in the paper, and so each reviewer will be only proficient in one or two of the areas and you can get away with murder in the other ones
Out today - less than a week after the defence of my PhD thesis!
We took a somewhat evolutionary perspective to talk about "unusual" flavors of H2A.Z remodelers. Check it out!
https://t.co/wbSSGlkYcN
Please RT. We are recruiting a PostDoc to study epigenetic mechanisms. Cutting-edge methods to predict, observe, and manipulate epigenetic processes - Develop and execute the next breakthrough ideas. #epigenetics https://t.co/pwRuxYqPg0.
Happy to start this week by sharing our new story showing that the transcriptional activity of the genome can be regulated by modulating the levels of pervasive histone modifications, such as H2AK119ub1, without the need for elaborate gene-specific targeting mechanisms 1/3