ANNU DALAL

[Arun K. Shukla @arshukla]

That absolute joy of holding the hard copy of the journal with your paper in your hands! Priceless!

[Shachie Sinha @ShachieSinha]

Excited to share our latest work on EP67, a peptide derived from C5a. By comparing its activity across human and mouse complement receptors, we uncover species-dependent differences that have important implications for translational research.

https://t.co/gHsLY8eZzc

[Arun K. Shukla @arshukla]

@IITKanpur An excellent collaboration with the laboratories of Cornelius Gati at USC and Trent Woodruff at University of Queenslad!!! Thank you so much!!!
@CorneliusGati @neurocomplement

[Arun K. Shukla @arshukla]

Spearheaded in our laboratory @IITKanpur by truly amazing students and fellows including Annu, Manish, Sudha, Manisankar, Ramanuj, and supported beautifully by Shachie, Nabarun, Divyanshu, Nilanjana, Debdatta, Ashna, Calvin, and Ameesha !!! Congratulations to all of you !!!

[Arun K. Shukla @arshukla]

Delighted to share our latest study on the activation of complement anaphylatoxin receptors, now published in PNAS!!! 1/n

Structural basis of complement anaphylatoxin receptor activation by an immunostimulant lead candidate | PNAS https://t.co/BxSlTVxiAE

[ANRF-National cryo-EM Facility @IITK @GpcrLab3434]

We are delighted that a paper including cryo-EM structures of an anaphylatoxin receptor C5aR2 determined at our facility @IITKanpur has been featured on the cover of @MolecularCell. We congratulate all the authors and wish them more success!
@ANRFIndia @DBTIndia @ICMRDELHI

[Arun K. Shukla @arshukla]

When Divyanshu and Nabarun joined the lab a couple of years ago, we clicked a photograph (👈👇) with our cover page poster in the background. I whispered to them - one day, we will be clicking one with your own. And, today was that day (👉👇).
#Amazing#Students#Proud#Mentor

[Arun K. Shukla @arshukla]

We are on the cover page😎!!!
@IITKanpur
@MolecularCell

[Nilanjana Banerjee @Nilanja26163665]

Huge congratulations to my lab family at the GPCR Biology Lab, IIT Kanpur, on their fantastic paper uncovering signaling bias at the complement anaphylatoxin receptor. What a beautiful piece of science. 🎉🎉🌟
https://t.co/BABQQXPOLg

[ANRF-National cryo-EM Facility @IITK @GpcrLab3434]

Structure of an atypical GPCR, the complement anaphylatoxin receptor, C5aR2, involved in various inflammatory disorders, determined at our facility, is now published in @MolecularCell. It represents one of the smallest membrane protein structures determined till date by cryo-EM!

[ASHNA REYAZ @AshnaReyaz]

Do read our latest study on the molecular mechanism behind the biased behavior of complement anaphylatoxin receptor C5aR2 .

[Nabarun Roy @noba_roon]

Congratulations to all the authors involved, @_DiVineANSHU_, @ANNUDALAL7, @SudhsM7, @gangulymoni, @RamanujBanerje5 and our amazing mentor @arshukla. Thanks to @BSBEIITK1, @IITKanpur, @GpcrLab3434 for supporting the research!

[Nabarun Roy @noba_roon]

Not only do we report the first ever #cryoem #structure of the human #C5aR2 receptor, we also show show a fascinating #helix8-mediated #gpcr_dimerization at the mouse C5aR2 receptor.

[Nabarun Roy @noba_roon]

Delighted to share our newest article in @MolecularCell where we dissect the intrinsic #signaling bias at another #arrestin-coupled #GPCR, the #complement receptor C5aR2!

https://t.co/uy9tWwtJWk

[Shachie Sinha @ShachieSinha]

Extremely delighted to share this exciting work from our lab exploring signaling bias at the complement anaphylatoxin receptors!!

[Arun K. Shukla @arshukla]

@IITKanpur @India_Alliance @ICMRDELHI @IndiaDST @ANRFIndia @DBTIndia @CSIR_IND Special thanks to @ANRFIndia for supporting the National cryo-EM Facility at IIT Kanpur used to collect some of the cryo-EM data reported in the paper including the structure of a small (~50kDa) ligand-GPCR complex without any fiducial marker😎. n/n

[Arun K. Shukla @arshukla]

@IITKanpur We are immensely thankful to @India_Alliance, @ICMRDELHI, @IndiaDST, @ANRFIndia, @DBTIndia, @CSIR_IND, Lady Tata Memorial Trust, and @IITKanpur supporting our research program over the years! 8/n

[Arun K. Shukla @arshukla]

@IITKanpur In our laboratory @IITKanpur, this work was spearheaded by truly outstanding students and fellows including Divyanshu Tiwari, Annu Dalal, Sudha Mishra, Manish K. Yadav, Nabarun Roy, Manisankar Ganguly, Nilanjana Banerjee, and Ramanuj Banerjee. 6/n

[Arun K. Shukla @arshukla]

A collaborative effort by an amazing team across three continents including our lab at @IITKanpur, and the labs of Profs. Osamu Nureki, U. Tokyo, Trent Woodruff, U. Queensland, Ka Young Chung, Sungkyunkwan U., Jana Selent, Pompeu Fabra U., and Asuka Inoue, U. Kyoto. 5/n

[Arun K. Shukla @arshukla]

Using the C5aR2 structures as a template, we also discover and optimize the first-in-class C5aR2-selective agonist, R8Y, and determine a cryo-EM structure to elucidate the binding mechanism, subtype-selectivity, and receptor activation. 4/n