Aisylu Shaidullina

[Michael Baym @baym]

This paper has been a long time coming: We looked at the genomes of historical bacterial samples over a century to look for trends of antibiotic resistance genes, finding multiple instances of them in infections before the age of antibiotics...

[Yves Briers @BriersYves]

We have a new exciting postdoc vacancy available in our group for #phage #host spectrum #engineering. Reach out for more information! Application is needed by January 26. Feel free to share in your network. https://t.co/1LWrZR3s01

[Akos T. Kovacs @EvolvedBiofilm]

Experimental horizontal transfer of phage-derived genes to Drosophila confers innate immunity to parasitoids

@CurrentBiology by @trnpl et al from @NKWhiteman
with group of István Andó from @BiologicalRese1 in Szeged

https://t.co/XaTJYQ1QJp

[Sorek Lab @SorekLab]

Published today @NatureComms

We discovered a bacterial NLR-like pattern recognition receptor that can sense 3 different viral proteins as a signature for infection. This explains its broad defense against different phage families

Congrats @nath_bechon!

https://t.co/ietOyj6Ngu

[Lennart Randau @RandauLab]

We have two postdoc positions available (funded for 3 years by Volkswagen Momentum) for research related to the de novo evolution of (i) bacterial anti-CRISPR activities and (ii) archaeal tRNA gene introns. Please feel free to share or apply: https://t.co/BinNWmmQsK

[Manuel Ares Arroyo @M_AresArroyo]

For the past two years, we have been working on a novel approach to identify origins of transfer by conjugation in plasmids from any bacterial species.

We are thrilled to see this work now published in @NatureMicrobiol after thorough peer review!

https://t.co/TpTxRy7jjd

[Nikel SEM Group @LabNikel]

Fresh #preprint from our group on a nice #synbio tool working in P. Putida and C. necator, led by @FilFederici and Francesco Luppino. Have a look at yhe #pippothread below for more insights!

[Olivier Borkowski @O_Borkowski]

Very interesting review from the @MaerklLab:

Regulatory Components for Bacterial Cell-Free Systems Engineering
https://t.co/PDfBZ23dxt

[Patrick Hsu @pdhsu]

🧵In new work, we report a systematic engineering roadmap to optimize large serine recombinases (LSRs) for direct, site-specific insertion into the human genome 🧬. We achieved over 50% insertion efficiency and 97% genome-wide specificity, a 10X improvement over our previous work

[Joe Bondy-Denomy @joeBondyDenomy]

Super important! Receptors matter!

[Jessica Sacher, PhD @JessicaSacher]

🧪 What I wish I'd known about lab notebooks in year 1:

A thread about what has actually worked for me (learned the hard way...) 🧵

[Nicholas M. I. Taylor Lab @NMITaylorLab]

🚨 New preprint alert! 🚨 We're excited to share our latest work: "Towards a complete phage tail fiber structure atlas" 🦠🔬 of first author @VKleinSousa
We developed #RBPseg for segmenting and merging phage tail fibers using structural prediction tools.
https://t.co/fnJosjhjul

[Puja Majumder @PujaMajumder91]

Very excited to share our recent work revealing a new chemistry for CRISPR!
Thankful to @ChristianF_Baca, Patel lab and @MarraffiniLab !
The CRISPR-associated adenosine deaminase Cad1 converts ATP to ITP to provide antiviral immunity: Cell https://t.co/l2MBrAQUcr

[Joe Bondy-Denomy @joeBondyDenomy]

Did you know that bacteria remember their past for many generations? In this new preprint from us (@VillaniAlexis and Senen Mendoza) and Banin lab (@ShmidovE ), we reveal the "how?" and "why?" underlying a long-standing mystery in bacterial memory. https://t.co/zFc8PDLqTu

[Cryptic Prophage (phage 🧬🪤 in 🦠) @crypticprophage]

https://t.co/Pjgy5KTUrK
Our thoughts on how toxins bound to TAs are activated: via conformation changes, not by selective degradation of ATs by a protease (makes little sense since both are structured). Remarkable insights determined by studying various TAs as they inhibit phage.

[TRIDIB MAHATA🇮🇳 @tridib_mahata]

Delighted to share our latest publication in @NatureMicrobiol - a dream of mine, symbolized by the purple line, that has now become a reality.
Discovery of a very widespread mobile island which play a crucial role in bacterial survival and competition.
https://t.co/hkiC3vGFsi

[Artyom Egorov @art_egorov]

See our preprint on systematic hotspot annotation! In addition to hotspot analysis, we provide precomputed iLund4u databases and two search modes: find if your query proteins are encoded in hotspots or map hotspots to a single phage/plasmid sequence. https://t.co/s67F0qeEsD

[Gemma C Atkinson @gem__atkinson]

Hot on the heels of Artyom's preprint on our locus visualisation tool LoVis4u comes a new preprint from him on systematic prediction of variable hotspots/islands in phage/plasmid/prokaryotic seqs. iLund4u is fast and can handle millions of seqs https://t.co/gsWQoRKsoY

[Joana Pereira @Joana_MPereira]

📢The future Pereira lab is hiring! We will start at @_VIB_AI in February 2025 and are looking for a postdoc to join and kick-start our team 🤓 If you want to leverage AI and large networks to explore and understand the protein universe 🌌, check below! https://t.co/R7n5vam6mS

[João Botelho @JoaoFTSBotelho]

Pipolins are bimodular platforms that maintain a reservoir of defense systems exchangeable with various bacterial genetic mobile elements

https://t.co/ABpVZNCvTr