Excited to share our new study in @Nature! We uncover how the vascular glycocalyx—a carbohydrate-rich coating on blood vessels—plays a crucial role in brain health and aging. A @wysscoray & @CarolynBertozzi labs collaboration. 🍭🧠 #glycotime (1/12)
https://t.co/To4Oz0MN0G
What Alzheimer noted as fat saccules in glia may have been lipid droplets. They can be induced by Abeta in microglia leading them to release factors that damage neurons. ApoE4 makes things worse https://t.co/KrOWS2RNZx. Congrats @Michael_S_Haney @robipalo and fantastic team
We have liftoff! 🚀 Excited to share our new work revealing an essential role of the transcription factor SRF in @myelination, out today @PNASNews. Led by the amazing @iram_tal and Miguel Garcia in collaboration with @fabiankern13, @wysscoray, and their labs.
I am thrilled to present our new study out in @Nature where we measure aging at organ-level resolution in living people with large-scale plasma proteomics + ML! From @wysscoray lab, co-led with former grad student @JarodRutledge1 1/12
A short summary of a long line of research on a new function of oligodendrocytes in brain energy metabolism - a big thank you to the many colleagues that should have also been coauthors. https://t.co/OFdFz8sTQv
Excited to share our work published in @ImmunityCP! We validated the human genetic findings that loss- and gain-of-function PLCG2 variants have opposite effects on transcriptional mechanisms, altering microglial phenotypes and AD pathology in mouse models. https://t.co/DBaVFsOvd3
Thrilled to see our map of the aging mouse brain published in @CellCellPress. We find that white matter tracts are hotspots of brain aging, where (micro)glia appear to age faster. Thanks to @wysscoray and an incredible team for getting this done!
https://t.co/EcPlT4mC7A
I’ve been super into the idea of intracellular molecular recording to measure cell dynamics, but this tech offers an interesting alternative: make the cells give you a sample!
I'm looking for a research assistant/associate to work with me on microglia, hematopoietic stem cells, lipidome, or aging clock. Please feel free to contact me! So many opportunities and projects in the Wyss-Coray lab! https://t.co/8B0YRtTMad
What controls the morphology of #myelin sheaths to enable them to fine-tune conduction velocity? TL;DR: Calcium (Ca2+) signaling; a.k.a. nature’s ultimate multitasker! Read our new pre-print to find out more, led by grad student @_manasi_iyer_! 🧵👇(1/n)
Some may have heard the news that I'll be soon joining Calico (more about that soon)
I'm looking for a (senior) research assistant who'd be interested to join. If you know someone who'd like to tackle brain aging on a new level - pls share! 🧠
https://t.co/wiJHe7XG52
Interested in the African killifish to study aging and 'suspended animation'? 🐟🐟🐟🐟🐠
We have lab Assistant positions open for killifish husbandry and research at Stanford!
Great positions before going to Graduate School!
https://t.co/lk08qLuL9f
https://t.co/F8JnXzChnS
Thank you @iram_tal for mentoring me through the process :)
Thank you @stshuken and Andrew Yang for being such great collaborators!
Have you ever wanted to study the cerebrospinal fluid (CSF) in rodents? Look no further, excited to share our protocol for the collection and infusion of CSF in mice 🐭
Have you ever done an “omic” (proteomic/transcriptomic/etc) experiment and wondered why we adjust p-values? Or how it works? Are you annoyed that you lose hits and want to avoid this? Want a 🔥 new R pkg for adjusting w/sensitivity? This paper is for YOU! https://t.co/uhg7qFt4b9
🚨 The SNAAP Mock interview schedule is LIVE 🚨 Go forth and book!
https://t.co/aekSiEfciG
Below in this thread we will also share some interview resources we shared with our mentors + mentees who filled out our interest form 👇👇
Could the African turquoise killifish hold the secret to the biology of aging? Researchers from the @BrunetLab and @wysscoray lab have developed new techniques to study the fish from birth to death to find out. https://t.co/PoMhFcQ7iQ
The Gate lab is proud to share our first manuscript, led by the incredibly talented @PiehlNatalie and @LynnOlst. In this manuscript, we discovered CSF immune system changes that occur with healthy brain aging and cognitive impairment. 1/10 https://t.co/qA7Pd9qniB
Do you have PLCG2 variants? Which one? The one confers increased AD risk or the one protects your brain and extends lifespan? We found that PLCG2 variants can orchestrate microglial responses in AD by distinct programs that can be therapeutically targeted! https://t.co/RalnQef4QB