Adam Helms

Genetic Cardiologist at University of Michigan

[Alessio Gasperetti, MD PhD @gasperettimd]

Proud to see this world wide effort for #DSP finally out! Kudos to my DSP-erados partner @RTCarrick for bringing this paper home and thanks to the many collaborators @ProtonotariosA @HughCalkinsMD @LaredoMikael @AdamHelmsMD @vnparikh @jpvantintelen @teRieleA @JuliaCTourigny

[Circulation @CircAHA]

#OriginalResearch In mice models, dysfunction adhesion was demonstrated to play a key role in the pathophysiology of arrhythmogenic cardiomyopathy #AHAJournals https://t.co/5dRdlRtetN

[Nosheen Reza, MD, MS @noshreza]

Like everything else she writes, a must read in @JACCJournals #JACCHF from @AG_EM33 💙💚

Critical Importance of Genetic Screening in Family Members

#cvGenetics

https://t.co/0Rg4dmf191

[F Moussavi-Harami, MD @FMoussaviHarami]

Outstanding @jclinicalinvest review about novel myosin-based interventions! @jct_ucb @sday_hcm

JCI - Myosin modulators: emerging approaches for the treatment of cardiomyopathies and heart failure https://t.co/10aoSbRQZo

[euan ashley @euanashley]

Excited to share some new work from us today on ultra-rapid genome sequencing for the diagnosis of critically ill children and adults.

In critical care settings, genetic diagnosis can shorten stays, direct precision therapy, save money, and help with family planning. 1/

[Emanuele Monda @MondaEmanuele]

In this randomized phase 2 trial, Valsartan improved cardiac structure and function in patients with early-stage sarcomeric HCM compared to placebo. @NatureMedicine @glimongelli @Fedeilardi @FGraziani_Grace @IacopoOlivotto @saramoscatelli7 @PeroneFrancesco https://t.co/1YogxeeuBc

[Adam Helms @AdamHelmsMD]

Excited to share our work on iPSC-derived 2D cardiac muscle bundles. Accessible and reproducible contractile assessment, insights on cardiac development, disease modeling. Read @NatureComms https://t.co/P9lL7vptWi @BakerLaboratory @LoriLIsom1 @yuweiwu_imb @umichCVC

[Matthew Solomonson @mattsolomonson]

Super excited to release https://t.co/CsJaykgnSp, a web application for browsing association results for 3,700 phenotypes across 281,850 individuals from the UK Biobank. The site features plots, tables, and controls for exploring billions of associations.

[Victoria Parikh, MD @vnparikh]

Our paper on “The genetic architecture of Plakophilin 2 cardiomyopathy” is now online at @GIMJournal.
Please check it out (and/or read the thread below) at https://t.co/Ymnjgzcs9T ! 1/n

[Nicholas Marston @marstonMD]

Our work in childhood-onset HCM now published in #EHJ @ESC_Journals

Take Home Points:

1) 3 peaks of HCM onset, peak in teens driven by Sarcomeric HCM

2) ~15% of HCM is diagnosed in childhood, carrying ~2%/yr event rate

3)⬆️risk of VT & VAD/Transplant compared to adult-onset

[Circulation: Genomic and Precision Medicine @Circ_Gen]

⚡Out today from @ChrisMHaggerty + team: Clinical Findings and Diagnostic Yield of Arrhythmogenic Cardiomyopathy through Genomic Screening of Pathogenic Desmosome Gene Variants https://t.co/awrcXq7dsf

@AHAScience #ahajournals #cardiogen

📽️@JeanetteErdmann @AnwarChahal

[Circulation @CircAHA]

EXPLORER-HCM CMR substudy finds that mavacamten favorably impacts cardiac structure in obstructive HCM. Read more: https://t.co/udZ9ijpzdQ #AHAJournals @S2beri

[Adam Helms @AdamHelmsMD]

Grateful to work with @EricSmithMD & outstanding collaborators incl @neallakdawala @DanielJacobyMD @emmcnally @LWilsbacher @AubertGregory. Great to see recurring themes in others just out @piriou_nicolas et al @ESC_Journals, Poller et al @JAHA_AHA, Gandjbakhch et al @Circ_Gen

[Circulation @CircAHA]

Desmoplakin Cardiomyopathy: A fibrotic & inflammatory form of cardiomyopathy distinct from typical #ARVC. Read more: #AHAJournals https://t.co/HFC5oTmXUs @AdamHelmsMD @umichCVC @DanielJacobyMD @VorovichHeartMD