🧵 Albumin in Critical Care: 70 Years, 700 Papers… Zero Benefit
1/
Albumin is the most studied fluid in critical care.
Decades of trials. Endless meta-analyses.
And yet – not a single clinically meaningful benefit.
Here’s why the entire theory collapses once you understand Extended Starling. 👇
@nickmmark@mac_eden Indeed no improvement in outcome both LINC & PARAMEDIC trials. LUCAS is a great logistical tool and a good cognitive offload in order to focus on reversible causes, POCUS, A.line and team dynamics.
Intubation used to be a lot scarier 😱
Relying on a straight line of sight meant difficult anatomy often left you flying blind. Modern VL turns scary surprises into manageable procedures. Don't risk it—relying on your eyes alone is an unnecessary risk in 2026. #AirwayManagement
Fresh blog: Six reasons to stop relying on the NPi (neurological pupil index)
👁️ NPi is based on a secret, proprietary formula used by one company
👁️ The neuroICU field was somehow convinced that we're too stupid to understand pupillometry tracings, so we need the NPi...(#1/2)
Antibiotics probably aren’t beneficial for patients with cirrhosis & GI bleeding
It will take time to change practice on this, but this is probably ripe for some antimicrobial stewardship
The idea that a few doses of ceftriaxone improve *mortality* in GI bleed was always sus…
What’s optimal PEEP for your patients with an increased BMI?
Our study showed a simple equation you can use:
PEEP = BMI/3
There’s variability, but BMI/3 approximates the mean optimal PEEP (by esophageal manometry) from BMI 25 to > 40
#foamcc
https://t.co/qwHioxtP6H
Albumin (A) replacement therapy in septic shock
In a multicenter RCT, 440 pts w septic shock were treated w A aiming to keep serum A >3.0 g/dL or w standard fluid therapy. 90-day mortality did not differ between the A group (43.3%) & controls (45.9%)
https://t.co/aVOvAW9n13
Do you feed ICU patients on vasopressors? Evidence says it can be safe—and lifesaving when patients are adequately resuscitated.
🆕 New paper online today in @SurgicalClinics
Key points 👇
• Vasopressors ≠ automatic contraindication to enteral nutrition
• Dose, stability, and trends matter more than presence alone
• Early trophic EN is reasonable once resuscitated
• Close monitoring for intolerance is essential
• PN remains critical when EN isn’t safe or feasible
Not “feed everyone early” ❌
Feed the right patient, at the right time, the right way ✅
How do you approach feeding patients on pressors in your ICU?
Protocol-driven or individualized?
Read the full paper: https://t.co/GEQi7cqSlt
#ICUNutrition #FOAMcc #ICURehab
@ICUnutrition@YukiKotani5
Check out trial bites
Each week, trialnites will post digestible, bite-sized information on a pivotal trial on an ICU topic, such as ARDS, sepsis, pressors, and more! Each topic will contain five weeks of trial summaries before transitioning into the next one. @NephroP@PulmPEEPs
https://t.co/yZDenjDy9o