“Pseudo–signet ring cells in ascitic fluid: a deceptive look that can lead you straight to the wrong diagnosis.”
Hydropic degeneration is known to occur in histiocytes and mesothelial cells.
(Cytospin preps)
This was called High-grade DCIS with comedo necrosis on stereotactic biopsy. You guys agree?
If you agree. There will be lumpectomy/mastectomy with sentinel lymph node and followed by radiation
If you disagree: Patient will go home. No surgery needed #breastpath
Not all that has ink is a true margin.
1. Make sure the ink is not in a cleft between fat lobules
2. Make sure you have a full cross-section of the tissue in the block. Tissue disruptions with ink are to be considered artifactual until proven otherwise
3. Check the diagram that shows where the section was taken from
4. If in doubt, walk over to the histology and lab and ask for the paraffin block. Looking at the entirety of the tissue within the block will give you information you cannot easily glean from the two-dimensional slide
#breastpath
✅ Gastrointestinal stromal tumor 🎯
• Most common mesenchymal tumor of the GI tract, characterized by differentiation toward interstitial cells of Cajal.
• Typically composed of uniform spindle cells with paranuclear vacuoles, or epithelioid cells.
• Immunohistochemistry usually shows diffuse and strong expression of KIT (CD117) and DOG1.
• Driven by activating mutations in KIT or PDGFRA in the vast majority of cases.
New in @Human_Pathology: ✌🏻 reviews in the 2026 Pathology Updates issue on GU pathology—bladder, prostate, kidney, testis, and penile tumors.
Grateful to great co-authors—hope it’s useful for pathologists and trainees!
🔗 https://t.co/SyMpuDkWsZ
🔗 https://t.co/oVPOcn0YmB
Voided urine reveals hyperchromatic urothelial cells and an X-shaped crystalloid.
What is your interpretation??
A) Negative for HGUC
B) Atypical urothelial cells
C) High-grade urothelial carcinoma (HGUC)
D) Low-grade urothelial neoplasm (LGUN)
#CytoPath#PathTwitter#Pathology
The world understands her cries, she is the sole survivor of the Malaya family massacre…
Israel murdered ALL 15 family members including her mother..🇵🇸💔
Kidney FNA of a 1.5 cm incidental mass reveals tight clusters of round cells with scant cytoplasm and fine chromatin on the smear, and small primitive cells resembling early metanephric tubular differentiation on the cell block... Dx: Metanephric adenoma. #cytology#cytopath
Ok friends, let's vote! Here is a transanal excision of a 20 mm polypoid mass. I will let you take polls and subsequently feed you with additional information. Don't cheat, do them sequentially - you might be surprised. Follow the thread!