@JCanNuSH Do you have any hypothesis about why the combo group continues lose lean mass after cessation? I would understand that the Bima alone group returns to baseline but the combo highlights some kind of missadaption to Bima treatment?
@AppleHelix The LDL-rising mechanism seems to be Bimagrumab specific and not related to the degree of weight loss. In the combo basically Sema cancels out the effect of Bima and LDL return to baseline at 48 weeks.
@JCanNuSH@AppleHelix They measured calorie intake at different time points but I can't reconcile the placebo group having the same calorie deficit than SEMA 2.4 at 48 weeks. Something is clearly off.
@ZKForTre@Lab_Inversion Moreover, the 25 mg Semaglutide in the Wegovy pill is with the new SNAC formulation with increased bioavailability. The 14 mg dose used in this trial would probably be equivalent to the 9 mg dose of oral Wegovy.