Gilbert

[Gilbert @AlbertAppleyard]

@ResearchPulse1 How can we get an estimation of current users based on these data? Thank you!

[Gilbert @AlbertAppleyard]

@JCanNuSH Do you have any hypothesis about why the combo group continues lose lean mass after cessation? I would understand that the Bima alone group returns to baseline but the combo highlights some kind of missadaption to Bima treatment?

[Gilbert @AlbertAppleyard]

@JCanNuSH @rn_flex The 84% on MRI comes from dose-pooled data (2.4 and 7.2 mg)

[Gilbert @AlbertAppleyard]

@JCanNuSH @Ashwinreads

[Gilbert @AlbertAppleyard]

@ZKForTre Did they compare brain penetration/circuit engagement of small molecule GLP1-RA vs peptide-based?

[Gilbert @AlbertAppleyard]

@ResearchPulse1 Thanks! What about Canada? Only the generic for Ozempic had been approved. When is generic Wegovy expected?

[Gilbert @AlbertAppleyard]

@ResearchPulse1 @JCanNuSH @MichaelAlbertMD Why do you expect differences in side effects in amycretin oral vs injectable?

[Gilbert @AlbertAppleyard]

@HenningLanger @MHSJohnWright How much weight people loose in your POC human study?

[Gilbert @AlbertAppleyard]

@AppleHelix The LDL-rising mechanism seems to be Bimagrumab specific and not related to the degree of weight loss. In the combo basically Sema cancels out the effect of Bima and LDL return to baseline at 48 weeks.

[Gilbert @AlbertAppleyard]

@JCanNuSH @AppleHelix They measured calorie intake at different time points but I can't reconcile the placebo group having the same calorie deficit than SEMA 2.4 at 48 weeks. Something is clearly off.

[Gilbert @AlbertAppleyard]

@JCanNuSH Thanks! Which then is equivalent to 9mg of Wegovy pill,right?

[Gilbert @AlbertAppleyard]

@ZKForTre @Lab_Inversion Moreover, the 25 mg Semaglutide in the Wegovy pill is with the new SNAC formulation with increased bioavailability. The 14 mg dose used in this trial would probably be equivalent to the 9 mg dose of oral Wegovy.

[Gilbert @AlbertAppleyard]

@scottisaacsmd It's 2.4/2.4 mg Cagrisema.

[Gilbert @AlbertAppleyard]

@ktimesk @HealthyAlfred In which study?

[Gilbert @AlbertAppleyard]

@BeverlyTchangMD @BevTchangMD @JohnSpeakman4

[Gilbert @AlbertAppleyard]

@BeverlyTchangMD @BevTchangMD @JohnSpeakman4 account has also been hacked

[Gilbert @AlbertAppleyard]

@NeilFlochMD @novonordisk Happy to help. You are a great source of information here