Alex C.Y. Chen

Instructor @MGHCancerCenter @harvardmed @broadinstitute @theNCI K99/R00, T32 fellow

[Waggoner Lab @LabWaggoner]

Single-cell map of the healthy human immune system across the lifespan reveals unique infant immune signatures @NatureComms @djamel_nehar
@jacksonlab
https://t.co/L0vLMg7PfC

[Cell @CellCellPress]

In the latest issue! Somatic cancer variants enriched in Alzheimer’s disease microglia-like cells drive inflammatory and proliferative states https://t.co/3Lx2Hj17Ks

[Cell @CellCellPress]

In the latest issue! p53 safeguards chemical reprogramming of human somatic cells toward pluripotency https://t.co/qWXo50UU5r

[Cell Stem Cell @CellStemCell]

Online Now! ZNF512B safeguards genome integrity at regulatory regions to repress the SASP and inflammation https://t.co/Vg4gtIC0pT #stemcells

[Aging Science News @AgingBiology]

Plasma proteomic signatures of cellular aging predict human disease
https://t.co/0MX81mzQ0W

[Waggoner Lab @LabWaggoner]

Preprint: Single-cell gain-of-function mapping reveals latent regulatory programs governing CD8+ T cell fate
https://t.co/lnDN6cwQOL

[Waggoner Lab @LabWaggoner]

Peptide-MHC-targeted engineered virus-like particles enable selective priming and gene editing of tumor-specific T cells @CellReports @davidrliu
https://t.co/MRs2rreE4H

[Waggoner Lab @LabWaggoner]

@biorxivpreprint Strong sustained type I IFN signaling acts cell intrinsically to impair IFNγ responses and cause tuberculosis susceptibility
https://t.co/4e3F61zV00

[Waggoner Lab @LabWaggoner]

@biorxivpreprint Citrate Compartmentalization Controls Calcium-Dependent Cytokine Production in Effector T Cells @alisoneringel @ragoninstitute
https://t.co/fqv7inngHi

[Cell @CellCellPress]

In the latest issue! Distinct in vivo dynamics of donor-derived stem cell memory CAR T cells post-allogeneic HSCT relapse https://t.co/Sa19Kd36Mw

[Vishva Dixit @dixitvishva]

A terrific perspective from Ivan Dikic
https://t.co/6JLgmwFzTC)

[Nature Biomedical Engineering @natBME]

Lipid nanoparticle composition directs systemic trafficking and tissue-specific T cell immunity after intramuscular injection https://t.co/HjIvzffJzi

[Alex C.Y. Chen @AlexChenChangYu]

@M_sharifitabar @DebattamaSen Thanks, Mehdi, we're looking into validating Zfp219 antibodies and further mechanistic follow-up on how it functions in T cells

[Rob Manguso @MangusoLab]

Excited to share out latest work, out this week in @NatureGenet . In this study, we using CRISPR screens to explore how sensing inflammatory cytokines exposes new tumor-intrinsic dependencies.
@broadinstitute @MGBResearchNews

https://t.co/GDeVFJUDcn

[Cell Stem Cell @CellStemCell]

Online Now! SPACE-seq integrates spatial transcriptomics and lineage tracing in native tissues https://t.co/7Ef0WWIz77 #stemcells

[Waggoner Lab @LabWaggoner]

p16High senescence-associated immune cells promote disease tolerance and healthy aging via TLR7 and STING control of adenosine concentrations @ImmunityCP
https://t.co/eWiEGS2GR3
https://t.co/paPRCMZY94

[Waggoner Lab @LabWaggoner]

Inflammatory cytokines induce new cancer dependencies @NatureGenet @broadinstitute @MangusoLab
https://t.co/s3bEckkyJ8

[Waggoner Lab @LabWaggoner]

Spotlight @ImmunityCP
Fibroblasts hold the key to TLS formation
https://t.co/Fr5PqizH2B

https://t.co/k4WtI7IQXU @Cancer_Cell

[Waggoner Lab @LabWaggoner]

Targeting Cancer-Specific Mutations with RNA-Triggered Chromatin Shredding @Nature @DoudnaJennifer @DoudnaLab @gladstonein @JingkunZeng https://t.co/Y2vgiyqYfH

[Waggoner Lab @LabWaggoner]

Aging restricts maturation of CXCL13+ T follicular helper cells in human immunity @CellReports @Stanford
https://t.co/ywLxAyDvU4