Alex Prevallet, DO

GI Fellow

[NEJM @NEJM]

Presented at #ASCO26:

Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results: https://t.co/xwLWBZYRzq

@ASCO

[On The Pen™ @ManOnThePen]

🚨 BREAKING:

CMS just confirmed the Medicare GLP-1 Bridge program is still a go for July 1, 2026.

Eligible Medicare patients will be able to access certain GLP-1 medications for $50/month.

Huge for $LLY and $NVO

[Max Marchione @maxmarchione]

12.4% of US adults are on a GLP-1s.

It was 5.8% in Feb 2024.

It doubled in 18 months. The global anti-obesity market is projected to grow from $19.6B today to $104.9B in 2035.

This is the fastest mainstream drug adoption of our lifetime.

[Dr. Jon Slotkin @slotkinjr]

@DrSamuelBHume I’m long LP-99999

[On The Pen™ @ManOnThePen]

MEET THE QUINTUPLE AGONIST 5 Receptor Obesity Drug! $LLY $NVO $VKTX https://t.co/pgKiFx5EYf

[Hims House @himshouse]

🚨 BREAKING: AMAZON ONE MEDICAL LAUNCHES GLP-1 PROGRAM

- Starting at $25/mo with insurance
- $149/mo cash-pay for oral GLP-1s (Wegovy Pill and Founday)
- $299/mo cash-pay for injectables (Wegovy Pen, Zepbound, KwikPen)

$NVO $LLY $HIMS

[Hims House @himshouse]

🚨 ELI LILLY IS PUSHING HARD TO GET RETATRUTIDE CLASSIFIED AS A "BIOLOGIC"

If successful, would extend market exclusivity beyond normal drug limits AND compounding pharmacies would be prohibited from making it

$LLY $NVO $HIMS

[TJ Parker⚡️ @tjparker]

It’s almost like this whole brand / generic thing is a great structure to incentive r&d while ensuring broad affordability on a reasonable timeline.

[Alex Prevallet, DO @AlexPrevallet]

@bryan_johnson English bulldog

[Sean Langenfeld @SeanLangenfeld]

Plenty of doctors promote bad information online.

Certainty does not equal expertise.

I learned long ago that it's better to provide good information that try to battle bad information, so I humbly offer this level 1 evidence on the safety and efficacy of colonoscopy:

1. Colonoscopy is safe, and the risk of perforation during screening is 3.1 per 10,000, or 0.031%. If you are that unlucky 1 in 3,226 people, the risk of it killing you is less than 5%
Source: https://t.co/XREVXOYGhf

2. Colonoscopy reduces your chance of getting colorectal cancer, and it reduces your chance of dying from colorectal cancer. In fact, there's a 68% reduction in CRC mortality with colonoscopy.
Source: https://t.co/9rqtHDCJUW

I try my best to ignore physicians who use twitter to promote pseudoscience and generate traffic to their websites, but it's Colorectal Cancer Awareness Month, so I feel obligated to share my thoughts.

[eNavvi @eNavvi]

Thinking about prescribing compounded medications? Here are three questions to ask before choosing a pharmacy partner.

1. Are they accredited? Look for PCAB or NABP accreditation—the recognized standards for compounding quality and safety.

2. Do they comply with USP standards? USP chapters 795, 797, and 800 govern non-sterile, sterile, and hazardous drug compounding, respectively.

3. Can you see pricing before you prescribe? Transparent cash pricing protects both your patients and your practice from unexpected costs.

eNavvi’s platform is designed to help clinicians answer all three questions before a single prescription is sent.

Informed prescribing starts with the right tools. Explore https://t.co/P2BoHYt2Ak

[On The Pen™ @ManOnThePen]

$LLY $NVO

🚨 BREAKING On The Pen Exclusive:
The FDA has approved the labeling for the #Zepbound #kwikPen in the US!

[Healthcare AI Guy @HealthcareAIGuy]

NEW: AI just became legally authorized to practice medicine in the US.

Actually prescribing with no doctor in the loop.

Doctronic launched a pilot where its AI renews prescriptions for chronic conditions, reviews history, asks questions, and sends the Rx to the pharmacy.

[Anthony DiGiorgio, DO, MHA @DrDiGiorgio]

Read more here: https://t.co/anK4G0VPg3

[Michael Albert, MD @MichaelAlbertMD]

FDA approves first-ever oral GLP-1RA for obesity and chronic weight management.

Meet Wegovy (semaglutide) tablets. https://t.co/HSdccHgAc9

[Andrew J Sauer MD @AndrewJSauer]

This might be the most badass brief report I’ve read in a long time.

In @NEJM

A team just published what feels like a glimpse straight into the future of cellular therapeutics: successful survival and function of transplanted allogeneic, CRISPR-edited beta cells with zero immunosuppression — in a real human with long-standing type 1 diabetes.

No anti-rejection meds.
No immune flare.
Glucose-responsive insulin secretion documented weeks after implantation.
A clean safety profile.

This is the kind of translational science that makes you think about how close we might be to rewriting what’s possible in autoimmune and metabolic disease.

Medicine is moving fast. This is one of those papers that makes you feel it.

[eNavvi @eNavvi]

🍂 Don’t let high drug prices get you down.

With eNavvi, prescriptions that usually cost $80 can drop to just $20! 💊💰

Compare cash prices instantly and prescribe smarter → https://t.co/UcM6vuHfoD

#eNavvi #FallSavings #DigitalHealth #AffordableCare

[eNavvi @eNavvi]

Save Big on Rivaroxaban 💊

Through eNavvi, physicians can now prescribe rivaroxaban directly to @CostPlusDrugs — giving patients transparent, upfront pricing.

✨ The deal:
Rivaroxaban as low as $20.73
Compared to retail prices over $200+
No surprises. Just real savings your patients can count on.

Prescribe with confidence, save patients money

[eNavvi @eNavvi]

☕️ Late night? Patients don’t wait for business hours.

With eNavvi, your free digital prescription pad, you can prescribe anytime, anywhere—right from your phone.

No desk. No hassle. Just care.

#PhysicianLife #DigitalHealth

[eNavvi @eNavvi]

🍁 eNavvi Fall Raffle 🍁
We’re giving away:
💻 1 MacBook Air
🎧 2 AirPods Pro (3rd Gen)

✅ Sign up = 1 entry
✅ Each referral = more entries (unlimited!)
📅 Sept 20 – Oct 31

Prescribe smarter. Save patients money. Win big.
👉 https://t.co/P2BoHYt2Ak

#Healthcare #Physician #Residency #PhysicianLife