Alexandru Stieber

Internal Medicine resident |
Passionate about rare diseases, rheumatology and neurology |
Aspiring diagnostician

[Alexandru Stieber @AlexStibi]

UBA1 gene mutations are NOT always synonymous with #VEXAS syndrome. As such, #GRAI (Romanian Group for Autoinflammatory Diseases) presents a small reminder of the clinical phenotypes associated with UBA1 mutated genotypes, such as SMAX2 or lung cancer in never smokers.

[NEJM @NEJM]

Presented at #EULAR2026:

In a phase 3 trial, obexelimab led to a lower risk of disease flares than placebo among patients with IgG4-related disease. Glucocorticoid use was lower and the incidence of remission was higher with obexelimab than with placebo. Full INDIGO trial results: https://t.co/Lynf6nmA9N

Editorial: Obexelimab and the Promise of Nondepleting B-Cell Therapy in IgG4-Related Disease https://t.co/BUQ7r8jVWz

@eular_org

[Casanova Lab @casanova_lab]

How I Treat: STAT3 hyper IgE syndrome https://t.co/kmlNRsFUn2

[Alexandru Stieber @AlexStibi]

@IlliasulK @docakx @IhabFathiSulima @CelestinoGutirr Livedoid vasculopathy

[Alexandru Stieber @AlexStibi]

@IlliasulK @docakx @IhabFathiSulima @CelestinoGutirr B12 deficiency - glossitis and neuropathy

[Alexandru Stieber @AlexStibi]

Highlight notification for today!! Can't wait to read it!! #histiocytosis

[CU Anschutz Lymphoma Program @CULymphoma]

Our rare disease specialist Dr. @cduarte8490 @CUHematology collaborated with @CU_pathology & @UTMDAnderson on a new publication on the diagnosis of subtypes of non-LCH. #pathtwitter cc @ZenggangPan

[Andreu Vilaseca @andreuvilaseca7]

Congrats on this prospective study in @GreenJournal!
Beyond the striking finding that nearly half of rapidly progressive dementia etiologies were immune-mediated, it is a great example of how neurologists can generate meaningful data while doing clinical work👏🏽
Example to follow!

[Andreu Vilaseca @andreuvilaseca7]

Great @NEJM review;
#Neurology should take note

Inflammatory myopathies are moving beyond antibody status to a pathophysiology-based understanding👇🏽
Inclusion Body → CD8+ T cells
Necrotizing or antisynthetase → pathogenic antibodies
Dermatomyositis → acquired interferonopathy

[Aravind Palraj @Rheumat_Aravind]

🧠 Not every inflammatory CNS lesion is MS.

When you see:
• Pachymeningitis
• Cranial neuropathies
• Long-segment myelitis
• Steroid-responsive CNS disease
• Basal meningeal enhancement

Think beyond demyelination.

Key neuro-rheumatology mimics:
🔹 Neurosarcoidosis
🔹 IgG4-related disease
🔹 Sjögren disease
🔹 Seronegative inflammatory CNS disorders
🔹 Chronic inflammatory hypertrophic pachymeningitis

MRI + systemic clues + PET-CT + biopsy often reveal the answer.

#Rheumatology #Neurology @docakx @IhabFathiSulima @DocPriyamMD @DrNikhilMD @Drkhenaizan #Neuroimmunology #MedTwitter #FOAMed #MedEd #Pachymeningitis #CNSInflammation

[Alberto Vogrig @Vogrig_Alberto]

A breakthrough in anti-IgLON5 disease research: patient-derived autoantibodies directly trigger neuronal hyperactivity, abnormal Tau redistribution/phosphorylation, and neuroinflammation — establishing a causal link between autoimmunity and Tau pathology.
https://t.co/QUz8f2aJEn

[Mayo Florida AutoImmune Neurology Group @Mayo_AING]

Pragmatic. Full of information. Cutting edge. Cool figs!

Honored to lead The Lancet review on Encephalitis. With amazing Sophie B, Ava E, Kiran T & @DeannaSaylor1

We hope you enjoy reading it:
https://t.co/0baEHVhjeH

@mayoneurores @mayocliniclabs @MayoClinic @NDCNOxford

[MoeTyson @MoeTyson]

How much do you know about #lupus? Play @lupusorg’s #KnowLupus game to find out and join me in making lupus visible! https://t.co/gNmq6oLyqY

[Alexandru Stieber @AlexStibi]

An amazing review on one of my favourite topics in #systemic diseases: inflammatory #myopathies!!
@NEJM

⬇️⬇️
🔗https://t.co/thvLEzNZ8c

[NEJM @NEJM]

Inflammatory myopathies are typically associated with a myositis-specific autoantibody that determines the diagnosis and prognosis. Myositis subgroups have distinct pathomechanisms that now allow for targeted therapies.

Learn more in the Review Article “Inflammatory Myopathies” by Yves Allenbach, MD, PhD, and Olivier Benveniste, MD, PhD: https://t.co/ZeCKdNe87v

[Jerome HADJADJ @HadjadjJerome]

Inflammatory Myopathies https://t.co/fjXEBWteJ7

[Saketh Vinjamuri @saketh_vinj]

Every square tells a story - a new schema, a sharpened illness script, a diagnostic pivot, a moment of uncertainty transformed into insight.

A constant reminder that the best part of medicine is learning together.

@CPSolvers Academy 😇

[Alexandru Stieber @AlexStibi]

@ASanchez_PS Or at least that's how I would frame it at first glance 👀

[Alexandru Stieber @AlexStibi]

@ASanchez_PS Substrate could be autonomic neuropathy/failure. In terms of causes: Parkinson's, amyloidosis, pure autonomic failure, neurogenic shoch from various acute causes.

[RadioGraphics @RadioGraphics]

Not all pulmonary emboli are thrombotic. NTPE includes septic, tumor, fat, air, and iatrogenic causes—often mimicking PE but needing different management. Imaging clues and clinical context are key for timely diagnosis. @BrighamRad @BWHRadEdu https://t.co/ASxSrgdXoh

[iCAA @iCAAassociation]

🚨🧠 happening now: exciting session on CAA on the intersection between stroke, neurodegeneration x neuroinflammation covering a large spectrum of CAA from ICH to degeneration, neuroinflammation, iatrogenic forms and back! Thought provoking session. #ESOC2026

[EFIM - European Federation of Internal Medicine @EFIM_EU]

📅 Mark your calendars for the 25th European Congress of Internal Medicine (ECIM 2027)!

🗓 31 March – 3 April 2027
📍Paris, France 🇫🇷

Integrating Evidence Based and Personalised Medicine in the heart of France.

Stay tuned👉https://t.co/EKWbHK8POg

#ECIM2027 #Paris