Zander

[Tom Bonier @tbonier]

This dipshit discovered that SQL server at one point replaced blank date of birth fields with a default of 01/01/1900, so he harassed an 86 year old woman.

[Avi Roy @agingroy]

Five cancers that used to be death sentences. Pancreatic. Glioblastoma. Triple-negative breast. Renal. Melanoma. The median survival for metastatic pancreatic cancer is still 6 months. Glioblastoma, 15 months.

Now personalized mRNA vaccines are producing complete remissions in some of these patients. Not responses. Remissions.

BioNTech’s pancreatic cancer vaccine has 6-year follow-up data. 8 of 16 patients who mounted an immune response are still alive. For a cancer that kills 95% of patients within 5 years, that's incredible.

Topol’s pyramid here maps the trajectory. From broad checkpoint inhibitors at the base to personalized neoantigen vaccines at the peak. The technology is climbing.

[Ian Weissman, DO @DrIanWeissman]

Pancreatic cancer mRNA vaccine shows lasting results in an early trial. Scientists caution that more research is needed, but nearly all of the patients who responded to the personalized vaccine are still alive six years later.
https://t.co/13GBL8ujOV

[Brad Polumbo @brad_polumbo]

Totally fake statistic. Literally objectively not even close to true. 1.3 million views.

[Basil🧡 @LinkofSunshine]

If you ever see posts by like Ron Paul talking about how we’re “wasting” government money on random studies, just remember that Ozempic comes from a paper on eating habits of an endangered lizard in the Sahara

[Dr. Catharine Young @DrCatharineY]

We were told NIH funding cuts were about eliminating DEI.

But the data now shows grants are down across nearly every field of medicine: cancer, diabetes, mental health, brain disorders.

With the greatest cuts hitting Alzheimer’s research, down more than 50%.

[Ziyad Al-Aly, MD @zalaly]

📢NEW: In a study of 600,000 people published today in @bmj_latest, we found GLP-1 drugs (Ozempic, Wegovy, Mounjaro) associated with reduced risk of addiction across alcohol, opioids, cocaine, cannabis, nicotine—and 50% fewer substance-related deaths.
🧵
https://t.co/SfurAFkzgT

[Dr Terry Simpson @drterrysimpson]

The COVID response exposed failures of institutions, not failures of science. That distinction matters.

Science did what science does: it updated as evidence changed. Masks, transmission dynamics, boosters, myocarditis risk—those corrections are a feature, not a bug. What eroded trust was poor communication, political overreach, and officials speaking with unwarranted certainty—not some mythical “Vaccine Industrial Complex.”

Layered on top of that was a well-funded, coordinated anti-vaccine ecosystem that exploited every misstep. The same network that denied COVID’s existence pivoted seamlessly to undermining vaccines, seeding distrust at every turn with cherry-picked data, conspiracy framing, and emotional anecdotes designed to spread faster than evidence.

Vaccine hesitancy wasn’t a logical outcome of science being wrong. It was the predictable result of policy errors weaponized by professional disinformation campaigns that profit from fear and grievance.

If science were the problem, the vaccines wouldn’t have reduced hospitalization and death by orders of magnitude. They did.

Distrust didn’t grow because people learned how science works. It grew because misinformation taught them—very effectively—to confuse institutional failure with scientific fraud.

[austerity is theft @wideofthepost]

DOGE didn’t net savings, because it lied about waste, fraud and abuse. That’s why those $5000 DOGE rebate checks you guys promised to send out never happened.

You guys did accomplish stealing Americans’ personal data, and got tons of park rangers and cancer researchers fired.

[Chase Brown @chaseabrown__]

Ryan Day said he takes full responsibility for Ohio State not beating Michigan the previous four years.

“You take it personally. I understand what it means. My family has been nine years now, so there’s nobody that wants to win this game more than me. But to win this game, it’s just a great moment,” Day said. “It’s one of those moments that you want to grab on for a while and just enjoy it. To see the joy in everyone’s face is really what this thing is all about. That’s what being a head coach is. It’s not about you. It’s not about raising trophies. It’s not about winning games. It’s about pouring back into the people that are around you. When I say people, it’s the players, it’s the coaches, it’s their families and the fans. Winning just gives us the opportunity to continue to do that, to make an impact.

“Everyone, the fans and all of our supporters can recognize all the work that gets put in. When it doesn’t go the right way, nobody wavered. We hung in there. It isn’t easy — nothing about this profession is easy. But I’m proud of the men we have and happy they got this win.”

[Molly Morrison @mollyhannahm]

no more simmons and russillo, doris got demoted. there is a niche group of people upset by both of these things and i’m one of them

[Zander @Alexcmayer]

Conservatives losing their minds about a socialist mayoral candidate of a city they don't live in while the actual president works to seize the means of production. Chefs kiss, no notes.

[James Tate @JamesTate121]

Scientists at the University of Florida have created a breakthrough mRNA cancer vaccine that erased deadly brain tumors in early human trials without chemo or radiation. Tested on four glioblastoma patients, the vaccine reprogrammed their immune systems within 48 hours to attack the tumor. Built from each patient’s own tumor cells and delivered via lipid nanoparticles, it showed success similar to earlier tests in mice and dogs. It is now moving into Phase 1 pediatric trials.

[Andrew Freedman @afreedma]

NEW: The NWS receives permission to hire up to 450 meteorologists/hydrologists/radar technicians after DOGE-related cuts. Agency also given a public safety exemption from federal hiring freeze. (1/2)

[Ernie Tedeschi @ernietedeschi]

BLS's first-release estimates of nonfarm payroll employment have gotten more, not less, accurate over time.

[Enron @Enron]

We didn’t do anything wrong

[Jay Bhattacharya, MD, PhD @NIHDirector_Jay]

Today, @NIH announced a new policy to cap how much publishers can charge NIH-supported scientists to make their work publicly accessible. This reflects our broader effort to restore public trust in public health by creating an open, honest, and transparent research atmosphere.

Read more ➡️ https://t.co/IC56qDzF8C

[Matt Darling 🌐🏗️ @besttrousers]

Median expert here: "lower end of the median" does not make sense.

The median is a point, not a range.

[Amanda Chen @_amandachen]

Excited to share that my PhD work is out in @Nature today! We engineered armoured CAR T cells to express therapeutic payloads only at the tumour site, to improve their safety and efficacy for the treatment of solid cancers. 1/14
https://t.co/lKo0k46wEy