AA01

BioMed x AI

[AA01 @AlgebraicAmin01]

@JosephJacks_ @StuartHameroff 🙂

[AA01 @AlgebraicAmin01]

@CalcCon Link?

[AA01 @AlgebraicAmin01]

1/ Not David Sinclair's first. In 2008, GlaxoSmithKline (GSK) acquired Sirtris Pharmaceuticals for $720 million , betting heavily on small-molecule activators of SIRT1 (such as resveratrol, SRT1720, and SRT1460) as groundbreaking mimetics for calorie restriction and longevity. However, competing teams from Amgen and Pfizer quickly threw down a biochemical gauntlet, proving that the original screening data was an illusion

[AA01 @AlgebraicAmin01]

@agingdoc1 @SmithDanaG 3/ Most of current anti-aging/ longevity research is just snake oil.

[AA01 @AlgebraicAmin01]

2/ The initial screens utilized a commercial fluorescent peptide substrate (Fluor de Lys). Independent labs demonstrated that the compounds did not actually interact with native SIRT1. Instead, they bound specifically to the artificial hydrophobic fluorophore tag on the peptide substrate, falsely amplifying deacetylase activity in vitro. When tested against native, untagged physiological substrates (like p53 or PGC-alpha), the therapeutic activation completely vanished.

[Nassim Nicholas Taleb @nntaleb]

You "need" academia to do research about as much as you "need" a tractor to tour New York City.

[AA01 @AlgebraicAmin01]

@demishassabis Promise clinical trials → miss the date → redefine what "clinical" meant → raise $2.1 billion announcing the "turbocharging" of the mission.

[AA01 @AlgebraicAmin01]

@demishassabis @IsomorphicLabs @IsomorphicLabs built / is building extraordinarily hypotheses generators . But it is announcing it as medicine. And $2.1 B attached to it makes it a dangerous one.

[AA01 @AlgebraicAmin01]

@brad_woolf Nice !

[AA01 @AlgebraicAmin01]

@MelindaBChu1 @aasthajs 🙏

[AA01 @AlgebraicAmin01]

@jonnym1ller Search not working

[AA01 @AlgebraicAmin01]

@jaynitx BS

[AA01 @AlgebraicAmin01]

@SakanaAILabs Sorry, you have been blocked
You are unable to access https://t.co/StlKnpQTr4

[AA01 @AlgebraicAmin01]

What a Faith!

[اسكندرية - Alexandria @Alexandria_egy1]

⚡️هذا المقطع حصل على 5M مليون مشاهدة في اقل من 24 ساعة

[اسكندرية - Alexandria @Alexandria_egy1]

⚡️هذا المقطع حصل على 5M مليون مشاهدة في اقل من 24 ساعة

[AA01 @AlgebraicAmin01]

@XinyuYuan402 Innovative

[AA01 @AlgebraicAmin01]

@rubenhassid The critical point though; is it objectively and adequately brutal ? what is your metric?

[AA01 @AlgebraicAmin01]

@michaelchchoi Could you please share any related references you're aware of, such as arXiv papers or similar resources on this topic?

[AA01 @AlgebraicAmin01]

Interesting perspective.

[Lain on the Blockchain @CryptoCyberia]

The most correct take on AI coding agents I have seen. You may not like it, but this is the truth of the matter.

[AA01 @AlgebraicAmin01]

@cgeorgiaw @huggingscience @instadeepai @pranamanam Very cool!