Burak Altintas

PGY-4 Peds/MGG resident at @WashU_PedsRes @MedgenW. Trained @hacettepetip ‘12-18, postdoc fellow @NCIEpiTraining #NCI_ClinicalGenetics ‘19-22.He/him👶🏽🧬🏳️‍🌈

[Burak Altintas @AltintasBurakMD]

#Residency #Match2026 season is here! Have you applied to WashU Genetics @WashUMedGen? It is a gem in Midwest and no, I am not biased!
Follow our IG page to learn more about us:
https://t.co/5xkJIdmyz4

[Burak Altintas @AltintasBurakMD]

🔋🧬💪🏽

[Martin Picard @MitoPsychoBio]

The cycle of life, every instant, in your mitochondria.

The major electron carrier in mitochondria is NAD+. When it collects an electron from the food you eat, NAD+ is converted into NADH. NADH then feeds the electron to the electron transport chain so the electron can flow to oxygen - the ultimate electron acceptor.

How easily electrons make their way to oxygen determines energy resistance (éR) following the energy resistance principle (ERP) https://t.co/eAL6i73l09

Mitochondrial matrix and cell cytoplasm are two different "sealed" compartments, but there is a special system that connects the NAD+/NADH pools between mito and cytoplasm: the Malate-Aspartate shuttle

The Malate-Aspartate shuttle shown below is how NADH from the cytoplasm (made by glycolysis) is carried into mitochondria. The electron transport chain can then regenerate NAD+ by respiring the flowing electron.

Everywhere in biology: energy transfer. Sometimes without molecular carriers. Here with a number of enzymatic intermediates, creating an integrated electrical circuit.

The circuit is in service of the flowing electron looking for a place to rest. Getting back onto oxygen to become H2O (water) again, as it was initially before getting ripped off by light energy and stuck onto a carbon backbone in a green leaf.

Animation by @janetiwasa lab
https://t.co/V7R07dVJbi

[Jon Brestoff @BrestoffLab]

Abstract submission deadline for 2025 #Mitochondrial #Medicine @UMDF is March 31

https://t.co/7ZmH1TGLzT
SciMed Scholarships and talks available from abstracts

June 18-21, 2025 in St Louis by the Arch

One of the most inspiring conferences I have been to!

Please RT

[The Journal of Inherited Metabolic Disease @JIMD_Editors]

Mito disease management is largely symptomatic. A subset respond well to specific vitamins or cofactors, but evidence of benefit in most is poor although prescribing is common.

A survey of global vitamin & cofactor prescribing practices in PMD.

👉 https://t.co/yorFRVERGI

[Burak Altintas @AltintasBurakMD]

Mito ❤️

[Burak Altintas @AltintasBurakMD]

#WorldMentalHealthDay2024

[WashU Medicine Medical Genetics @WashUMedGen]

As part of the PHEFREE Rare Disease Clinical Research Consortium, Dr. Kathy Grange and Desiree White published initial observations in the natural history of PAH deficiency https://t.co/9JKzBBgaJN

[Burak Altintas @AltintasBurakMD]

Good read

Multikingdom and functional gut microbiota markers for autism spectrum disorder | Nature Microbiology https://t.co/EbgYnxsao5

[Burak Altintas @AltintasBurakMD]

@simgemd @WUSTLmed @AngelaHirbe Safe travels and good luck with the residency. They are lucky to have you!

[Burak Altintas @AltintasBurakMD]

An amazing Donald Thurston Lectureship grand rounds talk from an inspiring physician-scientist and mentor, @SharonSavageMD, on bone marrow failure syndromes for the general pediatrician. We were honored to have you with us at @WashU_PedsRes!

[WashU Medicine Medical Genetics @WashUMedGen]

We are thrilled to announce our #Match2024 Pediatrics-Genetics combined residency match results @WUSTLPeds! Welcome Drs. Shufang Li and Ayesha Shaikh! @STLChildrens

[Burak Altintas @AltintasBurakMD]

A word to the wise.

[Sharon A. Savage, M.D. @SharonSavageMD]

So happy to be celebrating Dr Blanche Alter’s much deserved Coulter lifetime achievement award at #ASH23!

[Burak Altintas @AltintasBurakMD]

We looked at DiscovEHR exome data using a genome-first approach. This largest FA heterozygote study shows that heterozygous carriers (except for FA genes with known AD cancer predisposition) are not associated with an increased cancer risk. @GIMJournal

https://t.co/jrLYOx5kc2

[Burak Altintas @AltintasBurakMD]

Don’t miss Lisa McReynolds, MD PhD at #ASH23 workshop on Germline Predisposition to Hematopoietic Malignancies and BMF on Dec 8, sharing the results of our genome-first population study investigating the cancer risk in people w/ heterozygous FA variants. Paper coming out soon!🧬

[Burak Altintas @AltintasBurakMD]

Congratulations to @MACattackLab! Such great work and an inspiring physician-scientist!

[WashU Medicine @washumedicine]

Congratulations to Megan A. Cooper, MD, PhD, named Director of the Division of Rheumatology & Immunology at #WashUMed. Her lab research identifies genetic causes of rare pediatric immune disorders, uncovering two new conditions and their genetic origins. https://t.co/oS7I179rcK

[Sharon A. Savage, M.D. @SharonSavageMD]

Cancer risk in heterozygotes of 15 #FanconiAnemia genes not increased (except in known CPGs BRCA1/2, PALB2, BRIP1, RAD51C). Many FA relatives can breath a sigh of relief. Led by Dr Lisa McReynolds #NCI_ClinicalGenetics @NCIEpiTraining @FAresearchfund symposium #FARF23

[Burak Altintas @AltintasBurakMD]

Almost at the end of my month in the PICU that was demanding both physically and emotionally. Ton of learning from great fellows and attendings, fascinating medicine. Can’t wait for the second round just in 3 months!