Prof Andreas Suhrbier

Professor of Biomedical Science Research. All tweets are my own. RTs & Links & Follows do not equal QIMRB endorsement.

[Prof Andreas Suhrbier @AndreasSuhrbier]

@helder_nakaya Another great Australia Brazil collaboration. The processes described can be used to characterise how well any mouse model recapitulates human disease at any specific gene and pathway level. See also PLoS Pathog 18(9): e1010867 for COVID mouse models.

[Prof Andreas Suhrbier @AndreasSuhrbier]

https://t.co/0EkbMEygno

[Brian Nosek (@[email protected]) @BrianNosek]

Massive status bias in peer review.

534 reviewers randomized to review the same paper revealing the low status, high status, or neither author. 65% reject low status, 23% reject high status.

Amazing work by Juergen Huber and colleagues. #prc9

[Prof Andreas Suhrbier @AndreasSuhrbier]

Tomato flu @abcnews dodgy photograph, not the hand of a child. Also does not support the report of lesions the size of tomatoes, unless we're talking really very small tomatoes.

https://t.co/oSJ4cyZhb6

[Prof Andreas Suhrbier @AndreasSuhrbier]

Great word cloud. Perhaps time for an obvious leaf from @antonioguterres play book; gender parity in top UN jobs in 6 months. NHMRC could stop fiddling about at the edges and award 50% of NHMRC fellowships to women. At least try it for a year, and analyse the impact.

[Dr Susie Cartledge @susiecartledge]

@AnastasiaSMihai @ceo_nhmrc @nhmrc @DrAdrienneOneil Here’s the world cloud from todays session. Very interesting…

[Prof Andreas Suhrbier @AndreasSuhrbier]

Nice science replaces Trumpist sinophobia. Rabble-rousing polemic re lab leak from Wuhan Institute Virology (WIV) hopefully over. Prof Shi deserves an appology.

[Science Magazine @ScienceMagazine]

Analysis of spatial distributions of early #COVID19 cases and environmental samples from the Huanan market point to the market as the epicenter of #SARSCoV2 emergence, from activities associated with wildlife trade. https://t.co/tykjmEOGxW @MichaelWorobey @K_G_Andersen

[Prof Andreas Suhrbier @AndreasSuhrbier]

@ian_newzzz @lizziesiv @Vivian_Cheung2 @EricTopol Darwinian selection on steroids. Each COVID patient produces vast numbers of mutants, the fittest mutants go forth & multiply, onto the next patient etc. Mutations that promote transmission can thus be rapidly selected e.g. improved immune evasion, increased virus in aerosols etc

[Prof Andreas Suhrbier @AndreasSuhrbier]

@mjthinkscape @OrigamiFrog1 @The_PinkBee @lizziesiv @Vivian_Cheung2 @EricTopol Fully agree! https://t.co/wmJUSJlmAp

[Prof Andreas Suhrbier @AndreasSuhrbier]

@lizziesiv @Vivian_Cheung2 @EricTopol The evolutionary driver is transmission (T). High virulence is selected against if this decreases T; rapidly killing a host usually does not favour T, hence the mantra. However, at a population level, increased T may be achieved by increasing virulence (e.g. pnas.2203760119).

[Prof Andreas Suhrbier @AndreasSuhrbier]

Viral mutation is not the limiting factor for emergence of new strains. Vast numbers of mutants arise in every COVID patient.
"all of the virions produced over the course of a single infection probably cover every possible single nucleotide substitution"
https://t.co/3GGLJuEQcH

[Prof Andreas Suhrbier @AndreasSuhrbier]

@NYBG what a fantastic orchid exibit! Here is one from Stanthorpe, Queensland, Australia; the flying duck orchid.

[Prof Andreas Suhrbier @AndreasSuhrbier]

#microplastics

[Prof Andreas Suhrbier @AndreasSuhrbier]

Global plastic pollution has created a potential new biohazard for human health, microplastics (MPs). We consume up to a credit cards worth a week. Our recent mouse data shows that MP consumption can have overt proinflammatory consequences https://t.co/jOCxitKowM

[Prof Andreas Suhrbier @AndreasSuhrbier]

Global plastic pollution has created a potential new biohazard for human health, microplastics (MPs). We consume up to a credit cards worth a week. Our recent mouse data shows that MP consumption can have overt proinflammatory consequences https://t.co/jOCxitKowM

[Prof Andreas Suhrbier @AndreasSuhrbier]

The Journal Impact Factor is a driver against truth and utility. It has corrupted the purpose for undertaking government-funded biomedical research from “addressing industry/community needs and/or growing knowledge” to “publishing in high IF journals.” https://t.co/1L2q0lQLfq

[Prof Andreas Suhrbier @AndreasSuhrbier]

Synchronised pelicans @BirdlifeOz

[Prof Andreas Suhrbier @AndreasSuhrbier]

Sense at last (https://t.co/TrvSEimIS8) despite politics (2CKWgPT). (Hydroxy)chloroquine worked in vitro (high dose) but NOT (at bioavailable doses) in vivo for EBV (3dBKGDq) flu (3814Koo) dengue (31f5TRj) HIV (2NvaOoX) CHIKV (3850AFa) Ebola (3i3P164); and now SARS-CoV-2. Wow!

[Prof Andreas Suhrbier @AndreasSuhrbier]

Do for-profit journals add value to tax payer funded research or are they taking us for a ride? Tax payers fund the work & the reviewing & publication fees. Doctors pay $65 per paper to help them treat patients. No wonder there is 35-40% profit margin https://t.co/dSQLbwCQAe

[Prof Andreas Suhrbier @AndreasSuhrbier]

Australia has the lowest “Firms collaborating on innovation with higher education or public research institutions, 2012-14” in the OECD. Download from https://t.co/vCrlMI6odR p. 134. Surely a serious failure in government policy on research funding.

[Prof Andreas Suhrbier @AndreasSuhrbier]

Congratulations to Jim Aylward 2018 Clunies Ross Innovation Awardee (https://t.co/HOPg64x09i). An Ozzy biotech success story (US $287.5 m Peplin sale to Leo Pharma 2009). Product Picato, topical treatment for potentially precancerous sunspots. ≈ AU$ 78 m global sales in 2017.

[Prof Andreas Suhrbier @AndreasSuhrbier]

Australia produces ≈3% of the world’s top scientific research publications (https://t.co/tDyIHuYqLh), but only ≈0.6 % of the world’s triadic patents (https://t.co/7QRvNS1NCF); i.e. ≈5 fold worse than average at commercial translation.