Cortisol is a remarkable #hormone. We generally consider it a #stress hormone, which isn't wrong. But few appreciate its primary purpose: increase blood #glucose. Of course, this puts cortisol at odds with #insulin, promoting #insulinresistance. But how cortisol increases glucose is important to appreciate its systemic effects. Cortisol is so determined to provide the liver with substrate for the synthesis of new glucose that it will strip amino acids from proteins within skin, muscle, and more. This leads to a weakening of the tissues, causing stretch marks, easy bruising, sarcopenia (muscle wasting), and more. Any drug intervention that mimics cortisol (say to reduce inflammation or mitigate and autoimmune disease) will not only promote rapid insulin resistance, but lead to the tissue wasting mentioned above.
I gave a slam talk at the Luxembourg Science Slam last night. It was a great experience. As scientists we should never underestimate the importance of communicating with the general public and making them understand what we are doing and why we are doing it……
@BarbaraRwodzi Personally I think you should consider boosting domestic tourism first before inviting more airlines to fly these domestic routes. Prices of hotels in some of these holiday destinations is out of reach for most Zimbabweans. Tangirai ipapo Minister.
Mass spec imaging of metabolites at the organelle level had been thought impossible. AND accomplishing it w/ absolute quantification is like a double olympic gold medal (think 2020 Barshim & Tamberi). Done & done @MKurczy et al. @NatMetabolism https://t.co/IlldaGDP9a
In a cohort of 26 individuals with rare mtDNA mutations @ImogenFranklin6 @sarahjpickett et al. from @MitoResearch, @HI_Lab_NCL show enhanced negative selection in T cell lineages, following the hierarchy of T-cell differentiation and maturation https://t.co/WyIiIlf1n1
And just a month later, it feels like home @LIH_Luxembourg@IEE_Research_Gp. Fantastic science and highly professional, state-of-the-art labs! If you also want to experience this feeling, check out our job offer: https://t.co/xFGDpvtXhF. #FondationCancer#FnrLux