Tuna

[Al Jazeera English @AJEnglish]

A video of a Dutch policeman throwing a heavily pregnant woman to the ground has caused outrage. The woman says police attacked her at a migration centre where authorities had detained her Palestinian husband.

[🄲🄴🅅🅅🅅🄸🄾 🇨🇭🫶🇩🇪 nur✌🏽 @cevvvio]

hey @_FriedrichMerz

WIR SCHWEIZER ARBEITEN NICHT RUND 200 STUNDEN MEHR IM JAHR

Uns geht es dadurch NICHT besser,weil wir wie in Deutschland normale Arbeitszeiten arbeiten…Uns geht es DESHALB besser,weil WIR uns nicht schröpfen lassen

Sie reden von Toleranz?🤡

#Katholikentag

[Tuna @AriGold08]

@WallStreetMav Ja, weil sich Mehrleistung dort auch lohnt.

[Chris Masterjohn @ChrisMasterjohn]

Salt increases blood pressure (when it does) by attracting water into the blood, increasing the volume of blood pushing out against the blood vessel wall.

You can’t replicate this by dumping salt onto isolated endothelial cells because you don’t have an intact blood supply inside a closed lumen.

Inflammation responds to this to increase vascular permeability, allowing blood to leak out of the vessels. This lowers blood pressure directly and in the kidney it helps get rid of salt in the urine.

If you get sepsis, for example, the inflammation causes low blood pressure.

This paper is using vague terms like “endothelial dysfunction” to describe this totally adaptative inflammatory process and then trying to claim that salt doesn’t do anything directly but in fact it’s all driven by inflammation and cellular senescence.

This is total nonsense.

Salt attracts water.

This is basic chemistry with innumerable real-world applications as ancient and basic as drying meat or using salt as an antimicrobial.

There is nothing going on fundamentally with this except the transfer of water.

Everything else is secondary to this.

Potassium ABOLISHES the effect of salt on blood pressure by moving the water into your cells. If it goes in the cells, it doesn’t stay in the plasma. Plasma volume goes down, so blood pressure goes down.

But these people are trying to sell an experimental “senolytic” drug navitoclax by claiming that salt acts though some complicated process of cellular senescence to raise blood pressure.

But it doesn’t. It raises blood pressure by drawing water into the plasma.

Sustained high blood pressure causes senescence to the endothelial cells because high blood pressure is bad for them.

The catch: if you draw the water into your cells with a 1:1 ratio of potassium to sodium you hydrate your cells instead of raising your blood pressure.

Not because potassium has fancy immunomodulating senolytic gibberish about it but because it moves water to where it belongs.

[Bryan Johnson @bryan_johnson]

Salt has been blamed as the culprit for damaging your arteries.

A new mouse study puts salt-sensitive hypertension in context.

Salt doesn't do it directly, it triggers your immune system to do it.

4 weeks on a high-salt diet (8% NaCl) cut vasodilation by over 20% and spiked senescence markers in blood vessel walls. Pure NaCl did nothing to endothelial cells. The immune cytokine IL-16 alone replicated the full damage.

The senolytic (navitoclax) reversed it. Vascular function restored, likely via nitric oxide.

The mechanism behind salt-sensitive hypertension may be the immune response salt provokes, and the senescent cells that response leaves behind.

[Digimon world on GoG dreamlist @EtesechElp78167]

Hey did you know that digimon world 1 its on the gog dreamlist for a posible PC port rn? #digimon #dreamlist #gog

[Polymarket @Polymarket]

JUST IN: Germany now requires all men aged 17-45 to get permission from the military before leaving the country for more than 3 months.

[Francesca Albanese, UN Special Rapporteur oPt @FranceskAlbs]

They raped a man.
They gang-raped him.
They raped him so brutally that he had to be hospitalized.
Doctors documented the injuries.
The video of the assault was leaked.

Now the rapists are free.

This is not just unlawful and immoral. It is sick!

#ThisIsIsrael

[ALUTHEDON @Mbakaza4L]

Here’s a video of five Isreal soldiers sexually abusing a Palestinian detainee. The charges were dropped today sick society.

[Shining Science @ShiningScience]

🚨 This triggers an internal immune sensor that destroys HIV from within.

For decades, the primary hurdle in curing HIV has been the virus’s ability to weave its genetic code into human cells and remain dormant, effectively hiding from both the immune system and standard medications. However, researchers have identified a way to exploit an internal immune sensor called CARD8. Normally, HIV evades this sensor by delaying the activation of its protease enzymes until it has already exited the host cell. New research shows that a class of drugs known as targeted activators of cell kill (TACK) can force these enzymes to activate prematurely while still inside. This “trips the alarm,” causing the infected cell to undergo pyroptosis—a form of programmed cell suicide—before it can release new copies of the virus into the bloodstream.

Early clinical evidence has already shown significant promise, with a recent study involving human participants demonstrating a 20% to 50% reduction in hidden viral reservoirs after just four months of treatment. While this is not yet a total cure, the proof-of-principle suggests that depleting these reservoirs could eventually lead to a "functional cure," allowing patients to control the virus without lifelong medication. Beyond a total cure, these TACK molecules could drastically improve long-term health by reducing the chronic inflammation linked to heart disease and cancer in survivors. Major pharmaceutical developers are now accelerating the testing of even more potent molecules, marking a pivotal shift in the global effort to finally eliminate the HIV epidemic.

Source: Cohen, J. (2026). New HIV cure approach forces hidden virus into tripping immune sensor. Science.

[exQUIZitely 🕹️ @exQUIZitely]

The number of RTS games published in the 90s is massive. Obviously, not all were top-notch, but KKnD (Krush, Kill 'n' Destroy) was a real badass. Developed by Beam Software, an Australian team, it had that Mad Max vibe with its dystopian, nuclear-devastated world.

It lacked the brand power of the Command & Conquer series but was excellent nonetheless, especially given the smaller team and budget.

A sequel came out in 1998, but I always felt fonder of the original KKnD. Maybe the RTS genre just became oversaturated at some point...

[Smart Science @SmartScience]

🚨 Human Papilloma Virus (HPV) can now be completely eliminated, thanks to Mexican researchers.

[Arron Automata 🤖 @Arron_TK]

I’ve said it before and I’ll say it again:

Single player games > Live service games.

[Rino🚀 @RinoTheBouncer]

Players and the market have both spoken🚀

[Dr. Pat Soon-Shiong @DrPatrick]

Cancer is a shape shifting disease. We have figured a way to outsmart it through the power of IL-15 and natural killer cells. By 2026 we will grow trillions of natural killer cells from healthy donors and generate the 'world bank of natural killer cells' which can be administered to any patient without donor matching. That is how natural killer cells work.

@SpecialReport @BretBaier

[GamesLover with a Preference @lofi_lover0930]

It's time for a lot of game companies to realize that Live Service games ain't the answer

They'll keep burning more money than they earn if they keep forcing something that's basically "lightning in a bottle" aka Fortnite

GOOD Single Player games will keep thriving

[NIB @nib95_]

Resident Evil Requiem is a HUGE success.

Reportedly has highest ever day one franchise sales on #PlayStation, higher than COD Black Ops 7!

PS5 Pro also sold out on PS store in multiple countries. Seen folk buy on timeline too.

On Steam it hit RE record peak players too; 344k!

[GermanStrands @GermanStrands]

never stop making singleplayer games

[NikTek @NikTek]

This section in Resident Evil 9 makes me want to see an Open-World game made by Capcom in the future

It looks incredible