ariel

Entendiendo cosas en wiki.
Pathresident

[ariel @ArielPinto15]

Introduction to Crash Course Navigating Digital Information #1 https://t.co/Mf3BQMeIHs via @YouTube

[roman @Nozelcode]

Un youtuber brasileño le acaba de clavar un puñal a la suscripción de Photoshop.

Se llama PhotoGIMP: un parche gratuito (GPL-3.0) que convierte GIMP en una copia idéntica de Photoshop.

Misma interfaz, mismos paneles, mismos atajos de teclado y muchísimo más espacio para tu lienzo. Tus manos ya saben usarlo sin aprender nada nuevo.

Por qué está explotando?
- $0 en vez de $276 al año
- Sin cuenta Adobe ni login
- Todo se guarda en tu PC (nada en la nube)
- Compatible con Windows, Mac y Linux
- Se desinstala borrando una carpeta (sin rastro)

Instalación ridículamente fácil: copias 9 archivos y listo. +8.8k estrellas en GitHub y traducciones de la comunidad.

Uso personal y comercial 100% gratuito.

Enlace abajo

[Dr Kamlesh Darji @DrKamleshDarji1]

Concept #NEETPG

HPV & cervical cancer

A lot of NEET PG aspirants memorise "E6 = p53, E7 = Rb". But concept is very beautiful.

Start with what Human papilloma virus (HPV) wants. It's a virus. It needs your cell to keep dividing so it can copy its own DNA along with yours. A resting, non-dividing cell is useless to it. So HPV's whole game is to force the cell to keep cycling.
The problem for the virus is that your cell has two powerful guards stopping uncontrolled division: p53 and Rb (tumor suppressor proteins). So to hijack the cell, HPV has to take out both guards.
HPV does this with two proteins: E6 and E7. This is the heart of the whole thing.

E6 attacks p53. p53 is the "guardian of the genome" - when DNA is damaged, p53 either pauses the cell to repair it or orders the cell to commit apoptosis. E6 grabs p53 and tags it for destruction. So now, when the cell's DNA gets damaged, nobody stops it.

E7 attacks Rb. Rb's job is to hold the cell at the gate, stopping it from entering the cell cycle until it's truly meant to divide. E7 binds Rb and releases that brake. So now the gate is jammed open - the cell keeps pushing into division again and again.
Put the two together and you see the disaster. E7 forces the cell to divide non-stop. E6 removes the safety system that would normally catch the resulting damage or kill the cell. That's exactly the setup for cancer.

why it takes years, not weeks?? In most HPV infections the viral DNA just floats inside the cell and gets cleared - most infections resolve on their own. The danger comes when the viral DNA integrates into the host genome. Integration locks E6 and E7 into permanent overdrive, and that's when you cross from infection >> persistent dysplasia (CIN) >> invasive cancer.

[Felipe Templo Jr. ,MD, MBA 🕊 @thejourneymate]

Different Histological Types of Thyroid Carcinomas and Most Relevant Driver/Molecular Alterations 🔬
https://t.co/IGpvfY9GTk

[Pathology mcqs @Pathology_mcqs]

Exploring the comprehensive WHO classification of thyroid tumors from the 5th edition!
🔬This detailed chart breaks down the cellular origin, genetic classification, and histological features of various thyroid neoplasms

Reference: https://t.co/y3iurxi1PC

[Janira Navarro @Janiranavarro]

Thyroid: Classification of Follicular-Patterned Neoplasms

Dr. Nishino – 2025 Diagnostic Pathology Update #USCAP #pathology #PathTwitter #PathX

[Abhijit Das, MD @AbhijitSurgPath]

Thyroid Follicular Cell-Derived Neoplasms:
(Basic Facts for Residents)
Low risk and malignant neoplasms; NIFTP, FT-UMP, WDT-UMP, hyalinizing trabecular tumor, FVPTC, IEFVPTC, Differentiated HGTC, PDTC
#ThyroidTumorsUpdates
#BasicFactsForResidents
#MakeSurgiPathEasy

[ariel @ArielPinto15]

@JMGardnerMD My pgy1 mind told me this is a neurofibroma 😓

[Scott Kilpatrick, MD @ScottBikeethan]

Many probably don’t know that the Joint Pathology Center is the resurrection of the former AFIP, which was disestablished in 2005. Their tissue repository is incredible. DOD is Digitizing the World's Largest Pathological Sample Repository https://t.co/bMJ8AYpvtO

[Chandra Krishnan, MD @hematogones]

Bonus: just for fun, here is my original CNS tumor map from 2008 that I made as a resident at .@StanfordPath to help me get my brain around CNS tumors.

[ariel @ArielPinto15]

@vodafone_es Hola. Me han escrito por WhatsApp desde una tienda de Vodafone para pedirme datos personales o sino suspenderán mi servicio. ¿Les puedo enviar un DM con el número de teléfono y los mensajes que me han enviado para corroborar los mensajes?

[Sick! @sick_boy]

No, no se inunda x “la basura”

Gye tiene un sistema obsoleto q solo consiste en “descargar al rio”, sin zonas de absorcion/inundables (como deberia ser en este pantano) o sin solicitarle a grandes inversiones reservorios/reutilizacion como parte d concesiones onerosas d derechos

[Dr Kamlesh Darji @DrKamleshDarji1]

https://t.co/2fjClJ1gXJ

[Abhijit Das, MD @AbhijitSurgPath]

Kidney tumors - updates & newer entities (Basic facts for residents)

Molecularly defined entities involving TFE3, TFEB, ELOC, ALK, SMARCB1, SDH, FH etc. Evolving classification of papillary renal cell carcinoma.

#MakeSurgiPathEasy
#RenalTumorsUpdates

[Sumanta Das @SumantaDas_7]

The Epigenetic Engines of Cancer: Decoding the SWI/SNF Complex 🧬⚙️

From the brain (AT/RT) to the lung (SMARCA4-def) to the kidney (MRT). Different organs. Different ages. Same Molecular Culprit.

Why does the loss of one "Chromatin Remodeler" create the most aggressive, chemo-resistant tumors?

A Mega-Thread on SWI/SNF, SMARCA4, & INI1. 🧵👇
#PathX #PathTwitter #MedEd #Oncology

[José Mario @JoseMarioMX]

1️⃣ Derrocar a un dictador suena moralmente justo. Nadie llora por un tirano. Pero el derecho internacional no se construyó para proteger a los buenos, sino para contener a los poderosos. Por eso prohíbe la fuerza casi sin excepciones: no porque ignore la injusticia, sino porque sabe que, si cada país decide a quién “liberar” a balazos, el mundo vuelve a la ley del más fuerte.

2️⃣ El problema no es Maduro. El problema es el precedente. Cuando la fuerza militar se usa para cambiar gobiernos sin reglas claras, la soberanía deja de ser un límite y se vuelve un estorbo. Hoy es “derrocar a un dictador”; mañana será “corregir una elección”, “proteger intereses”, “restaurar el orden”. El derecho no absuelve dictaduras, pero tampoco legitima cruzadas unilaterales.

3️⃣ La pregunta incómoda no es si un tirano merece caer, sino quién decide cuándo y cómo. Porque la historia enseña algo brutal: sacar al dictador es fácil; construir justicia después, no. Y cuando la legalidad se rompe en nombre del bien, casi siempre lo que sigue no es libertad, sino caos, violencia y nuevas víctimas. El derecho existe para recordarnos eso, incluso cuando incomoda.

[Arjun (Raj) Manrai @arjunmanrai]

Super cool to see CaBot picked by @harvardmed as one of the top stories of 2025! Much more from @tabuckley_ ahead!

https://t.co/HNOFgQoctL

[Liang Cheng, MD @LiangChengMD]

Do you know how to FISH? I am delighted to share our 20+ years of experience with FISH, just published in @Human_Pathology (PMID: 40782985) -  Everything You Need to Know About FISH!

This comprehensive review covers the full spectrum of fluorescence in situ hybridization (FISH) applications from HER2 FISH interpretation and 1p/19q deletion cutoffs to emerging applications, future directions, and the role of AI.

On a personal note, this paper has been two decades in the making. I began writing it nearly 20 years ago, when my late colleague and friend, Dr. John Eble, asked me to establish a molecular lab and implement FISH testing at Indiana University. Seeing it finally published is deeply gratifying. It’s true that it can take a decade (or two!) to write a comprehensive review  and I’m thrilled that it’s finally out. I hope you find it a valuable and practical resource.

This review provides practical guidelines for the clinical application of interphase FISH in diagnostic surgical pathology. It discusses key technical considerations - including tissue preparation, interpretation thresholds, and limitations - and highlights selected diagnostic applications relevant to daily surgical pathology practice.
The central dogma that abnormal chromosomal DNA determines a diseased cell’s phenotype continues to have powerful clinical utility for tumor diagnosis and treatment. FISH remains a versatile, cost-effective, and rapid tool for detecting chromosomal alterations.

Even as technology evolves, pathologists must remain mindful of FISH’s underlying chemistry, potential artifacts, and clinical context. It continues to be an indispensable and irreplaceable adjunct in surgical pathology for resolving diagnostic dilemmas and identifying therapeutic targets.
The full article is available at the following link: 
https://t.co/d1Cerr9alo

#Pathology    #Pathologists   #SurgPath  #pathresidents  #MolDx  #MolPath

[ariel @ArielPinto15]

Sí que la tiene. A todos les llega el billete por la campaña del sí. Ojalá les vaya mal con ese dinero en la vida.

[ariel @ArielPinto15]

Da igual, ninguno vive porque no hay MEDICINAS NI INSUMOS.

[Alvaro Rosero León @alvaro_exa]

Si una persona de grupo prioritario y otra, llegan al hospital en el mismo estado de gravedad, ¿a quién atienden primero?.

[ariel @ArielPinto15]

Dije que no iba a amargarme aquí pero esto no tiene explicación. Están jodiendo por nimiedades en un sector donde los médicos tienen que hacer malabares para intentar salvar vidas.