arpit gupta

One day molecules will start responding

[arpit gupta @ArpitG_26]

Thrilled to share first paper from my postdoc. A structural-guided functional insight into this unique chaperone. Congratulations to co-authors @alfredlentzsch, Alex and @yifan_ucsf lab. https://t.co/S4HwS2sXiD

[Biology-PDF IISERM @pdfiisermohali]

Congratulations to Dr. Amar Deep @iamamardeeep on joining IISER Mohali @IiserMohali as a new faculty member in the Department of Biological Sciences! @DBS_IISERM .🎉
His lab will dive deep into microbial immune systems & their molecular mechanisms.
Exciting times ahead! 🔍🦠

[David R. Liu @davidrliu]

Another medical milestone! The first patient treated with a prime edited therapeutic shows positive clinical outcomes consistent with effective rescue of his chronic granulomatous disease (CGD), a debilitating and life-shortening primary immunodeficiency.
At least 19 base editing and prime editing clinical trials
have begun, with at least 7 trials reporting clinical outcomes (highlighted in green in the table below). They treat a wide range of diseases both in vivo and ex vivo. And while the U.S. support for science is now in crisis, that there are more base editing and prime editing clinical trials serving patients outside of the U.S. (13) than within the U.S. (9), despite the fact that these technologies were developed in our lab in the U.S.
https://t.co/GvYU512g9f

[Kohler Proteostasis Lab @VKohler_Lab]

What is #AcademicKindness and why does it matter to me?

https://t.co/FEbnxWdHsG

#KohlerProteostasisLab #Mentorship #Leadership #Communication #STEM

[Caltech @Caltech]

Four members of the Caltech faculty are elected to the National Academy of Sciences (NAS) this year. Election to the academy is considered one of the highest professional honors that can be bestowed upon a scientist.

https://t.co/eqTxBqJASK

[ShorterLab @ShorterLab]

An Msp1-Protease Chimera Captures Transient AAA+ Interactions and Unveils Ost4 Mislocalization Errors https://t.co/4HalvMIcC9

[Alfred Lentzsch @alfredlentzsch]

Please check out this review we wrote in @JMolBiol , together with Profs. Jae Ho Lee and Shu-ou Shan, on the mechanisms of cotranslational protein biogenesis
https://t.co/u0OAqVsQhQ

[Amar Deep @iamamardeeep]

Our recent work on bacterial Wadjet system is out today in @MolecularCell 🎊🎉

[Alzheimer's Research UK @AlzResearchUK]

Every 3 minutes dementia steals a happily ever after. You can change the ending.

Stand with Alzheimer’s Research UK #ForACure by watching and sharing our film to help change the ending.

[Deuerling Lab @DeuerlingLab]

We are delighted to have been a part of this Story and want to thank our collaborators Shu-ou Shan at @Caltech and @The_Ban_Lab at @ETH_en for the awesome work we achieved together.

[ShorterLab @ShorterLab]

The Ability of DNAJB6b to Suppress Amyloid Formation Depends on the Chaperone Aggregation State | ACS Chemical Neuroscience https://t.co/mSUAdC5P3h

[arpit gupta @ArpitG_26]

https://t.co/vIUyW2e0hj

[arpit gupta @ArpitG_26]

Distinct types of intramitochondrial protein aggregates protect mitochondria against proteotoxic stress: Cell Reports https://t.co/o8vc7nc2DD

[ShorterLab @ShorterLab]

Cryo-EM structures of amyloid-β and tau filaments in Down syndrome: https://t.co/d4MA2w8cA7

[Alice Ting @aliceyting]

LYTACs pioneered by @CarolynBertozzi opened the door to degradation of cell surface and extracellular proteins through lysosomal targeting. Here, we introduce genetically-encoded LYTACs, or GELYTACs, which are (1) easier to produce by recombinant expression (LYTACs, antibody conjugates to glycopeptides, are harder to make), (2) amenable to engineering via directed evolution, and (3) possible to secrete from therapeutic cells such as T-cells.

We demonstrate degradation of various soluble targets, including TGFb, IL6R ectodomain, and mCherry with GELYTACs optimized via yeast display directed evolution, added either as recombinant protein or secreted from living T-cells.

Congratulations to lead author @Jony_theChemist, our wonderful collaborators Sean Yamada-Hunter, @LouaiLabanieh and @molecular_elena from the @mackalllab, and great teaming up again with the formidable @CarolynBertozzi.

https://t.co/WVYAadruBP

[David M. Sabatini @DMSabatini]

Many, many congratulations to Grace Liu on the publication of her creative thesis work on an evolutionary mechanism for how the mTORC1 pathway acquires new nutrient sensors. There are surely many more sensors to discover.
https://t.co/Pjmfbcy7MQ

[Jackrel Lab Members @JackrelLab]

📢We are excited to share that our paper on HTRA1 remodeling of alpha-synuclein is available now online with @NatureComms! Check out our main findings below 👇

[Ventura's Lab @PPMC_UAB]

Structure of Amyloid Peptide Ribbons Characterized by Electron Microscopy, Atomic Force Microscopy, and Solid-State Nuclear Magnetic Resonance | The Journal of Physical Chemistry B https://t.co/wjW9ndrlXA

[David R. Liu @davidrliu]

If you ever wondered what would happen if one person received 217 COVID vaccine injections over 2.5 years, now you don’t have to wonder.

[Amit Tuli @amit_tuli]

Excited to share latest study from the lab led by a dedicated & amazing graduate student @Kshitizwalia that shows how #ORF3a, a well-known virulence factor of #SARS-CoV-2, blocks #lysosome function by modulating #Rab7 GTPase cycle @NatureComms
https://t.co/jQiYJrJTLl
A 🧵

[AD/PD - Advances in Science & Therapy @adpdnet]

What a day! 😍 #ADPD2024
To finish it, here are some takeaways from Tau mechanisms 01: