Rayoflight

New song: Tujhpe Fida. Slow groove, Soft fire. Spotify: | Music, Markets, Tech | IIT Kgp, IIM Cal

[Rayoflight @ArunChillara]

@alok_ajay Your argument is wrong even within the bounds of your ridiculous framing. Every reserved seat is a seat taken away from General Quota. Therefore General Quota has a right to know what you are doing with it.

[Rayoflight @ArunChillara]

Selling is tough. Networking is core to it. Most people think networking is personality, actually it is practice. Hitesh is one of the best networkers I know and he has explained how it is done in his insightful and easy to read book. Get a copy and get started. ROI is infinite😁

[Hitesh Gossain @hiteshgossain]

I am happy to share that my book "Quietly Connected" is available at a bookstore near you (and amazon)!!

The response has been incredibly encouraging - and It has already been reviewed by top strategy consultants, Unicorn founders, students & a lot more. https://t.co/VYIlPaoeuE

[Rayoflight @ArunChillara]

@DudespostingWs Most people cant sprint at the speed of marathon record holders who maintain that pace for 2 hours.

[Rayoflight @ArunChillara]

@PompeyPedro And there was a third forward at the end who he missed

[Rayoflight @ArunChillara]

@PompeyPedro He had 2 options which he missed under pressure: 1) Pull back on left and pass through to front of Haaland 2) Feint towards Haaland and move right for a clean shot at goal. In the end he was neither here nor there. Poor chap.

[Ananth Rupanagudi @AnanthOnTrack]

An Indian scientist at Harvard discovered ATP (Adenosine Triphosphate). Then he helped create the first chemotherapy drug and the first tetracycline antibiotic. Harvard still refused him tenure. A bowling alley would not let him bowl. He died at 53, without an obituary.

His medicines save tens of millions of lives every year. Most American doctors who prescribe them have no idea what his name was. His name was Yellapragada Subbarow (Subba Rao).

He was born in 1895 in Bhimavaram, India. His father was a Sanskrit scholar who died from tropical sprue. Tropical sprue is an acquired malabsorptive disorder found in tropical regions, characterized by chronic diarrhea, weight loss, and severe nutritional deficiencies. It is most commonly associated with deficiencies in vitamin B12 and folic acid, resulting in anemia, fatigue, and glossitis. The same disease killed two of his brothers. As a child, Subbarow watched them fade away and decided he would spend his life fighting disease.

He failed his school exams twice. Passed on the third attempt. His future father-in-law paid for his medical school books. Subbarow married his daughter and repaid the debt. In October 1922, he arrived in Boston with borrowed money and broken English. He was 27. He entered Harvard Medical School and joined the biochemistry PhD program.

He began working under a senior researcher named Cyrus Fiske. Long hours. Little pay. But he was at Harvard, and he did not care. In 1925, they developed the Fiske-SubbaRow assay, a method for measuring phosphorus in body fluids. It is still used today in kidney failure testing, vitamin D testing, and prostate cancer work. It became one of the most cited methods in biochemistry history.

Then they found something even bigger in 1926 - ATP - Adenosine triphosphate. The energy molecule that powers every cell in every living thing on Earth. That discovery changed biochemistry. It also proved that the 1922 Nobel laureate had been wrong about how muscles worked. Muscles did not run on glycogen. They ran on ATP.

Subbarow earned his PhD in 1930. He stayed at Harvard for another decade. Paper after paper. Discovery after discovery. And every year, Harvard refused to promote him. The biochemistry department had never given tenure to a foreigner. They were not going to begin with an Indian.

His colleagues took him fishing. Played tennis with him. Came to dinner at his home. Then voted against him year after year. Outside the laboratory, he met the same wall. He bought an airplane and learned to fly because he loved flying. Once, he tried to go bowling. The local alley refused him entry. The sign said it was “open only to the Caucasian race.”

Then Fiske turned against him. The senior researcher began blocking Subbarow’s discoveries out of jealousy. Some of Subbarow’s work had to be rediscovered years later by other scientists because Fiske kept his findings hidden.

May 1940. Harvard denied him tenure for the last time. After 17 years of groundbreaking work, he walked away. Lederle Laboratories in New York hired him as Associate Director of Research. By the end of the year, he was Director. In the next eight years, he changed medicine. He developed diethylcarbamazine, an oral medicine that killed the tropical worms crippling American soldiers in the Pacific. The World Health Organization still uses it.

He isolated folic acid from liver and worked out how to produce it on a large scale. Today, folic acid in pregnancy prevents birth defects in tens of millions of pregnancies every year. The same family of diseases that killed his father and brothers became preventable because of him.

Then Dr. Sidney Farber called from Boston with an idea: maybe a drug that blocked folic acid in cancer cells could kill childhood leukemia. Subbarow’s team created the drug. They called it Aminopterin. In December 1947, Farber gave it to an eight-year-old boy dying from leukemia. Within weeks, the cancer cells began to disappear.

It was the first chemotherapy drug in history. The first time anyone had put cancer into remission using a pill. Subbarow’s team later refined it into Amethopterin, now known as methotrexate. It became a gold standard treatment for leukemia, lymphoma, breast cancer, and lung cancer. Then rheumatoid arthritis, psoriasis, and Crohn’s disease. The World Health Organization lists it as an essential medicine. Tens of millions of people use it every year.

In 1948, his lab produced Aureomycin. The first tetracycline antibiotic - a broad-spectrum one that killed typhus, cholera, pneumonia, and many bacteria that penicillin could not touch. It opened the door to the whole tetracycline family: doxycycline, minocycline, and drugs still used today against plague, malaria, anthrax, and drug-resistant infections.

He was 53 years old. He had created medicines that would save tens of millions of lives. August 8, 1948. Yellapragada Subbarow suffered a heart attack at his home in New York and died. No American newspaper gave him a front-page obituary. No university held a memorial. The Nobel Committee never honoured him. His own colleague George Hitchings later won a 1988 Nobel Prize for work built directly on Subbarow’s foundation. Subbarow was not even nominated.

In 1950, Argosy magazine published a feature about him titled “Miracle Man of the Miracle Drugs.” It began with a line that still hits hard. “You’ve probably never heard of Dr. Yellapragada Subbarow. Yet because he lived, you may be alive and are well today. Because he lived, you may live longer.”

Most Americans had not heard of him in 1950. Most still have not. Harvard has never officially honoured him. American medical schools mostly do not teach his name. The Nobel Committee that honoured Hitchings for work built on his foundation never corrected the record. Every methotrexate prescription written today remains silent about the man behind it.

India remembers. The government issued a postage stamp for his 100th birthday. His childhood home became a museum. Indian medical schools teach his name. But the country that denied him tenure, refused to let him bowl, and allowed him to die unknown - the same country that uses his drugs every day - still mostly does not know him.

Here is the truth. If someone you know has ever taken methotrexate for cancer or an autoimmune disease. If someone you love has taken folic acid during pregnancy. If you have ever been prescribed doxycycline for an infection. That was him. Yellapragada Subbarow. Born 1895. Died 1948. Saved tens of millions of lives, while a country he loved barely knows what it owes him.

Please remember his name and let your near and dear know about this little-known scientific legend born on this soil but never got the true recognition that he deserved. A story you need to know. A story all of us need to know. #Medicine #Unknownlegends @centerofright @KiranKS

[DAE India @DAEIndia]

🇮🇳 India Tops the World at the 56th International Physics Olympiad 2026!

🥇🥇🥇🥇🥇India's young physicists deliver an extraordinary performance at #IPhO2026 in Colombia. All five members of the Indian team win Gold Medals. 1/3
@PMOIndia @DrJitendraSingh @HBCSE_TIFR @TIFRScience

[Rayoflight @ArunChillara]

Is there a good reason AI doesn’t have access to time and date?

[Rayoflight @ArunChillara]

i don't know of any brain that has no sense of time. With all due respect to AI, it does not even track time. I asked Claude about it. It said that it has no access to time feature in the chat, nor is it able to see server time.

[Rayoflight @ArunChillara]

Doesn’t even realize that the accident happened because a car reversed and halted on an expressway. Whatever else the Scorpio might have done , the collision happened because the other car was in the wrong. This is the level of civic discourse.

[Naimisha (ନୈମିଷା) 🇮🇳 @SpeakNaimisha]

I was on the same road just a day before that tragic accident. A few things stood out to me then, and they deserve serious attention now:

1. Lane discipline matters. Why was the Scorpio reportedly speeding in the middle lane at around 100 km/h? Overtaking Lane rules exist for a reason.

2. The stretch is exhausting. It's a long drive, and fatigue is a real risk factor that often gets underestimated.

3. Driving should be based on rules, not convenience. I saw multiple vehicles reversing on a highway/mountain stretch just to save 10–15 minutes. That's not smart driving; it's dangerous driving.

4. For God's sake, use indicators. Don't risk the lives of those behind you and then step out of the car acting like a WWF fighter after creating fuss.

5. Please stop driving as if you're Max Verstappen. Public roads are not racetracks, and overconfidence behind the wheel can cost lives.

6. Certain state cars should be banned. Iykwim.

[Rayoflight @ArunChillara]

This gent who is calling other people stupid and dumb doesn’t realize that even if the off ramp was functional , reversing and stopping on an expressway is wrong. This is the level of civic discourse. How will things improve?

[Shivam Vahia @ShivamVahia]

Were both the car drivers blind?!

The Tiago reversing is trying to go onto an off-ramp that's clearly not open or under construction. The sand/dust gives it away.

The car that crashes into that Tiago is cruising in the left most lane when all three lanes are available. You can't even blame the trucks here for being in the right.

Both the drivers are at fault. Please don't drive if a straight road can hypnotize you.

Also, this is what happens when "Packages" of expressways are opened as sections and people are too dumb and lazy, they follow what Google Map shows them. The stupid guy reversing clearly thought that off-ramp is functional.

[Rayoflight @ArunChillara]

A long real estate depression is coming

[Elon Musk @elonmusk]

India’s birth rate has fallen below replacement.

Among those most educated, India’s birth rate fell below replacement many years ago.

[Parimal @Fintech03]

In the 1990s, India was facing a Biological Colonization. If Dr. R.A. Mashelkar had not stepped in, we might have ended up paying a royalty to a US corporation every time we used turmeric on a wound/exported Basmati rice.

In 1997, a Texas-based company called RiceTec was granted a patent by the USPTO (US Patent & Trademark Office) for Basmati Rice lines & grains. They claimed they had invented a superior strain of rice. Mashelkar realized that if this patent stood, Indian farmers would be barred from selling their own rice under the name Basmati in the US. It was a theft of Geographical Intellectual Property.

He did not just shout Injustice. He assembled a team to find Genetic Fingerprints. They proved that the new rice was actually derived from Indian germplasm that had existed for centuries. The USPTO was forced to strike down the majority of the claims.

2 researchers at the University of Mississippi were granted a patent for the use of turmeric in healing wounds. To a Western patent officer, this was a novel invention. To an Indian, it was something their grandmother did every day. Mashelkar produced an ancient Sanskrit text as Prior Art. The USPTO demanded a translation. He provided evidence from the Journal of the Indian Medical Association dating back to 1953 + ancient Ayurvedic texts.

This was the 1st time in history that a patent granted to a US entity was successfully challenged & revoked based on the Traditional Knowledge of a developing country.

Mashelkar also realized that India could not fight 10000 legal battles every yr. He needed a Scalable Solution. Patent officers in the West were not malicious; they were just Data Blind. They could not read Sanskrit/Tamil/Persian. If a discovery was not in an English journal, it did not exist in their system.

He hired 100s of experts (Ayurveda practitioners, IT engineers, & Patent lawyers). They took 500000+ formulations & converted them into a digitized Shloka to Code format. The data was rendered in English, French, German, Japanese, & Spanish.

Today, India has signed agreements with the USPTO, the European Patent Office, & others. Before an officer grants a patent, they run a TKDL Scan. If the herb/method is in the library, the patent is rejected instantly.

[Rayoflight @ArunChillara]

Next the CBI is going to argue that no case of bribery can be prosecuted because it would mean that a large number of government officials would also need to be prosecuted because bribery is all-pervasive in the Indian system

[Saurav Das @SauravDassss]

#StoryAlert🚨

The CBI’s Freudian Slip

The Central Bureau of Investigation’s latest response to former Delhi Chief Minister Arvind Kejriwal’s additional affidavit, filed in support of his plea seeking Justice Swarana Kanta Sharma’s recusal from hearing the CBI’s challenge to the trial court’s discharge of him and 22 others in the Delhi liquor policy case, contains a mistake.

And it is not a minor one.

In trying to dismiss Kejriwal’s argument as absurd, the CBI may well have ended up admitting to something far more damning about the state of India’s judicial culture: the Judge-Relatives-Government Counsel business.

My special column for @frontline_india—https://t.co/PxGFWAkXfs

[Rayoflight @ArunChillara]

@rameshofficial0 @kamalsharmaa87 @ivishnums @IAnupamaa @ShermyBiharie @_final_prophet_ @adityakmish00 @TheRetweeter_x @Manendramani86 @bipin7189_4bjp strict action = suspension

[Rayoflight @ArunChillara]

@r0ck3t23 AI is not alone. Robots are coming too.

[Rayoflight @ArunChillara]

@ChrisMurphyCT The reason this theory is nonsense is that that there are scores of people below the top guy who think about all this and plan and execute for it. To think that leader of any country, forget the US, plans and executes all by himself is another level of hallucination.

[Rayoflight @ArunChillara]

@iMicrocap Good it tells you that overvaluation is not a broad based issue

[Rayoflight @ArunChillara]

@_The_Prophet__ Time for the boring company to get involved and find an inland route for oil in the next 7 days. @elonmusk

[Rayoflight @ArunChillara]

@NYCMayor when I read it first time, I thought the white supermacist threw the bomb