Ashwin Subbaraj

Physiotherapist, Passionate abt the keto diet in treating chronic pain. Type II DM in remission and a Keto convert !#LCHF #keto #LCHPMF

[Ashwin Subbaraj @AshPT2018]

@RogerSeheult Hello Dr. Seheult, Kudos on the study; any caveats for daylight, IR rays and it's mitochondrial implications in rainy, cold weather like PNW winters? Thanks!

[Ashwin Subbaraj @AshPT2018]

@MetabolicUncle Hello there; thank you for all your posts; repeating a question re: your post yesterday. Any data on Taurine and L-Arginine in combination with the above or with Co-Q 10 in MELAS related mitochondrial deficiency? Thanks a bunch!

[Ashwin Subbaraj @AshPT2018]

@MetabolicUncle Any data on Taurine and L-Arginine in combination with the above or with Co-Q 10 in MELAS related mitochondrial deficiency?

[Ashwin Subbaraj @AshPT2018]

@ProperCloth Sorry for your loss Chris; May she RIP🙏

[Nick Norwitz MD PhD @nicknorwitz]

🚨 Stress Can Change Microbiome & Gut Health!🚨

New research shows HOW...

1/3) New data published in @CellCellPress shows how a region in the brain, the central amygdala, directly controls glands in the gut that feed certain gut bacteria, altering gut symptoms (e.g. bloating) and gut function.

For more specifics
🧠Stress changes activity in the brain.

🧠A brain region called the central amygdala signals via the Vagus nerve to glands in the intestines called Brunner’s Glands.

🧠Brunner’s glands secrete mucin to feed gut bacteria, including Lactobacillus.

❌And Stress, via this axis, inhibits Bruner’s glands starving Lactobacillus

🧠Changes in microbiome composition alter gut function, leading to bloating and other unfortunate symptoms.

#GutHealth #MentalHealthIsHealth #microbiome

🚨These data provide a specific cascade to explain how stress alters the microbiome.

It’s not hand wavy fluffy mumbo jumbo… it’s hard-core metabolic science that also lays the groundwork for potential solutions to improve mental health AND gut health simultaneously …

cc @ChrisPalmerMD (#BrainEnergy🧠 @hubermanlab (physiologic sigh, see 2/3) @bschermd @Metabolic_Mind @janellison

[Nick Norwitz MD PhD @nicknorwitz]

2/2) Here is the paper: https://t.co/BT5BEHXNnH

Video Abstract: https://t.co/URB8JrCD0S

🧠 Unique Population, Unique Data
The LMHR group is distinct population with exceptionally high LDL-C, high HDL-C and low triglycerides that emerges as a metabolic response to carbohydrate restriction vis-a-vis the Lipid Energy Model

⚠️ Caveats
These are preliminary data, so let’s not overstate the findings.

However, dismissing them outright would ignore the unique metabolic response of this population, which differs significantly from other causes of high LDL-C.

📢 Your Role
Now it’s time to put YOU to work! Share this paper, tweet, and video abstract widely.

These data need to be discussed, even if (especially if) it makes some people uncomfortable.

🤓Further Learning
I encourage you to explore more on ApoB, ACM, and different causes of high LDL. You can start on this 30+ video playlist on the topic.
https://t.co/2bLWxujGr1

🌍 Stay Open-Minded
Avoid becoming a hyper-extremist—whether an “LDL denier” or “LMHR denier.” This research is still evolving, and we’ll make the most progress by staying open to new data and discussing it thoughtfully
#LMHR #KetoDiet #LDL

[Ashwin Subbaraj @AshPT2018]

@seizuresalad You are like a phoenix; If some of us are lucky to be around, we will get to hear tales from you when you hit 100 :)

[Ashwin Subbaraj @AshPT2018]

@DougieReynolds @lowcarbusa Awesome; stellar work @sarah4info @DougieReynolds ; Much needed and Thank you!

[Ashwin Subbaraj @AshPT2018]

@dlifein 😂😂

[Ashwin Subbaraj @AshPT2018]

@travelingenes @X Amazing job Grace; a testament to your grit, determination and singleminded-ness. Wishing you the best in your future endeavors 🙏

[Ashwin Subbaraj @AshPT2018]

@bava23 @shashiiyengar @travelingenes I’ll second that Shashi. A young superstar in the metabolic health field who has made it her mission to spread this exact message. Will be a valuable addition to the conference.

[Ashwin Subbaraj @AshPT2018]

@CBR_T2D Same issue here. Wordle should eliminate words with 4 different options when we get 4 letters right😜

[Ashwin Subbaraj @AshPT2018]

@shashiiyengar @kumaranupam6 I had to do it first based on my own research and show my remission to the GP, give her all the research, now she prescribes it to other patients with metabolic issues. This is in Canada though and a humble, smart Dr😜Keep up your great work @shashiiyengar @dlifein

[Ashwin Subbaraj @AshPT2018]

@mrc314 So sorry to hear that. Wishing a speedy recovery 🙏🙏

[Ashwin Subbaraj @AshPT2018]

@thelowcarb_rd @lowcarbGP @KamilaRCGP @rcgp @garytaubes @FructoseNo @BenBikmanPhD @bigfatsurprise @BDA_Dietitians @ClareWilsonMed @lowcarb_aus @drchatterjeeuk That is brillantly put @lowcarbGP 🙏🙏

[Ashwin Subbaraj @AshPT2018]

@hormonedietdoc @heidilynnwins Merry Christmas to you, Heidi and the kids doc😊

[Adrian Soto-Mota @AdrianSotoMota]

We hope you'll find our work interesting/useful.

If you did. Help us share it!
🙏🏼🔄🙏🏼🔄

@BenBikmanPhD
@DominicDAgosti2
@lowcarbGP
@KenDBerryMD
@SBakerMD
@PeterAttiaMD
@EstebanDL
@thecurbsiders
@bschermd
@PlantChompers
@DrGiovanniD
@SBakerMD
@DoctorTro

https://t.co/NKVAz0uska

[Dave Feldman @realDaveFeldman]

🚨🚨🚨🚨🚨🚨🚨🚨
BREAKING: @BudoffMd has now presented the matched analysis for:
KETO (#LMHRstudy) vs Control (#MiHeart)
-🙏Please RT🙏-

METHODS – 80 Participants of #LMHRstudy fell within #MiHeart age range and were then matched 1:1 for age, gender, race, diabetes mellitus, hyperlipidemia, hypertension, and past smoking to asymptomatic subjects from the #MiHeart cohort.

PRIMARY ANALYSIS – High resolution heart scans (#CCTA) allowing for primary analysis of Total Plaque Score (TPS), Total Stenosis Score (TSS) and Segment Involvement Score (SIS)

RESULTS
The matched mean age was 55.5 years, with mean #LDL cholesterol of 272 mg/dL (max LDL-C 591) mg/dl and mean 4.7 years duration on a ketogenic diet.

🚨 There was no significant difference in coronary plaque burden of #LMHRstudy (mean LDL-C 272) cohort as compared to #MiHeart controls (mean LDL 123 mg/dl); nb: pre-KETO LDL-C in KETO group was 122 mg/dl

🚨 There was no significant difference in CAC (median and IQR) [0 (0,56)] versus [1 (0, 49)], p = 0.520

🚨 No relationship of LDL-C elevations and plaque

⚠️ This analysis is on baseline scans and the study is still ongoing for second CCTA completion in our cohort by February of 2024. And as always, please continue to work with your doctor.

- I will have my own video reaction and thoughts in the coming hours.

🙏🙏🙏 to everyone -- and I mean everyone -- who helped us get to this pivotal milestone. 🙏🙏🙏

[Ashwin Subbaraj @AshPT2018]

@mrc314 🙏🙏

[Ashwin Subbaraj @AshPT2018]

@LDLSkeptic That's such a concise and fantastic review David🙏