Aydogan Lab

We study principles of biological time control with a focus on the emerging concept of autonomous clocks.

Columbia University & HHMI

[Aydogan Lab @AydoganLab]

EXCITED to unroll this 🧵 on our new story on the metabolic licensing of animal development... How did we even get here..?

https://t.co/Z5mhTtLGde

Early embryo is thought of a pre-set machine that's set to go once it's fertilized - check out this gorgeous 📽️from Phil Keller!

[Tapomoy Bhattacharjee @tapomoy89]

Delighted to share our work on physical confinement-driven cell-cycle regulation, now published in @NatureComms
📜https://t.co/OzRCBLVKu6
It was led by @padmanabh97 & @Mridul_Gautam01 with @bagade_nikita18 @ESoftbio @NCBS_Bangalore & collab with Dr Sunil Laxman @DBT_inStem
A🧵:

[Arif Ashraf @aribidopsis]

🔬🍀

I am a big fan of @PeishanYi Peishan's work. A really cool study from his lab published recently @NewPhyt

ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT machineries play crucial roles in vacuolar trafficking and cytokinesis in the moss Physcomitrium patens

https://t.co/J95QiVk7Jr

[Columbia University @Columbia]

What do you do after winning the @NobelPrize? If you're Columbia Professor Michael Woodford, newly named a Nobel laureate in Economic Sciences, you head to Uris Hall and give your students an exam. Woodford entered the classroom to cheers and applause from the students in his course “Cognitive Mechanisms and Economic Behavior.”

“It's just a staggering piece of news,” Woodford said of receiving the honor. He is the 16th Columbian to receive this prize in economics, and the University's 89th Nobel laureate.

Hear more from Woodford about the award: https://t.co/fvqtEQakBh

📹 Columbia University
📷 Diane Bondareff/Columbia University

[Aydogan Lab @AydoganLab]

@DrMofatteh @EANSonline50 Amazingly fascinating to see that the future of neuroscience and medicine is in the right hands!!! Many congratulations @DrMofatteh!!!

[Dr Mohammad Mofatteh @DrMofatteh]

Tremendous honour to receive the Brain & Spine Best Reviewer of the Year Award at #EANS2026 in Hamburg, presented by Editor-in-Chief Prof Wilco Peul and @EANSonline50 President Prof Francesco Sala. Grateful for the recognition and excited for what lies ahead!
#Neurosurgery #EANS

[Aydogan Lab @AydoganLab]

It's so great to see efforts to begin unifying thoughts and findings on senescence, a field that has remained spread across multiple disciplines. Good job @NatureCellBio for taking the initiative, and @EnginLaboratory and colleagues for their efforts putting this together!

[Feyza Engin @EnginLaboratory]

Thank you to Nature Cell Biology for inviting me to contribute to the Viewpoint “Goals and Challenges for Senescence Research”. It was a pleasure to discuss the challenges in senescence research and to exchange perspectives on where the field is heading.
https://t.co/MsxQ4ahqJF

[Nagaraj Balasubramanian @AdhesionLab]

Good read....@JCellBiol
https://t.co/vZ4cc2nLSd

[Aydogan Lab @AydoganLab]

@wc_ratcliff Keep'em coming, Will! They are great!

[Will Ratcliff @wc_ratcliff]

Application review for the GRC in Microbial Population Biology will start October 15th! Please apply before then if you are keen on coming.
https://t.co/PkUzSv95QD

[Aydogan Lab @AydoganLab]

@wc_ratcliff @FLeung521201 Oh lol, I wanted to add the joke, when there is "will", there is a way :D

[Aydogan Lab @AydoganLab]

@wc_ratcliff @FLeung521201 Thanks Will! This is awesome

[Aydogan Lab @AydoganLab]

@FLeung521201 @wc_ratcliff Ditto @wc_ratcliff!

[Keita Masui @keita_masui]

同じ遺伝子を2つ持っていても、脳は育ちきらない。

哺乳類の遺伝子には、父由来か母由来かで働き方が変わるものがある。ゲノムインプリンティング（刷り込み）と呼ばれ、ヒトとマウスでおよそ200個。ただし母のゲノムだけを持つ単為発生の胚は着床後まもなく死ぬため、その先で何が起きるかは長く手つかずのまま。

大阪大学と東邦大学の山口新平氏らが作ったのがCReP法。中脳と小脳を作れないWnt1欠損の胚を受け皿にし、そこへ単為発生由来の細胞を入れて脳を埋めさせる。脳の形は完全に戻った一方、体重は伸びず、多くは生後まもなく死亡。

その脳では、父由来でしか働かない遺伝子Dlk1が減り、細胞の運命を決めるNotchの信号が過剰に。神経細胞が減り、グリアへ偏っていた。老化研究がいま向き合っているのも配列ではなく印の側で、層としては地続き。

どの遺伝子を持つか、から、どちらから受け取ったか、へ。発生の読み方が一段深くなった。

※マウスの基礎研究で、ヒトへの外挿は未検証。培養系の検証は3〜4例規模。

出所：Scientific Reports（2026/6/8）Parthenogenote-derived brain unveils the critical role of paternal genome in neural development
https://t.co/iX8VrP3Emp
@SciReports

[Aydogan Lab @AydoganLab]

Go Garner Lab!!! Sincere congratulations to @rikkigarner!!!

[Rikki Garner @rikkigarner]

Excited to announce that the Rikki Garner lab has opened its doors in beautiful Austin, TX! Our interdisciplinary lab @UTAustin @UT_MBS investigates tissue fluidity as a universal physical regulator of multicellular patterning in health and disease. https://t.co/HvLRbDqrxu 1/n

[Kazuhiro Maeshima @kazu_maeshima]

How are mitotic chromosomes built? 🏗️ Our Review @TrendsGenetics revisits the classical chromosome scaffold model and connects it to condensins, topoIIα, and physical forces. We propose interphase chromatin domains as “building blocks”🧩of chromosomes:
https://t.co/AQgiZlSjYS

[Sachin Kotak @Sachin_mitosis]

Can light build centrosome-like activity? 💡🔬 We introduce LISA (Light-Induced Spindle Assembly), @emboreports By clustering Aurora A with optogenetics, we control centrosome-like microtubule nucleation that rescues spindle defects after centrosome loss. https://t.co/QtCYBGKJF7

[Tamer Onder @Tamer_Onder]

🚨 Excited to share our latest preprint on @bioRxiv!

We’ve developed a rapid & highly efficient method to generate human 8-cell-like cells (ri8CLCs) for modeling early human embryogenesis and ZGA.

📖 Read the full paper here: https://t.co/XOz7zUirNh 🧪👇

[Aydogan Lab @AydoganLab]

This is just SO good..!!!!

[Abberior @Abberior]

Nuclear pore complexes labelled for NUP96🟥 and Mab414🟦, imaged from confocal to high-power STED.

Each imaging mode reveals progressively finer structural details.

One sample, multiple imaging modes - with the #MIRAVAPolyscope.

#fluorescencefriday

[Gabrijela Dumbović @Gabrijela_D]

Incredibly happy to share the first publication from our lab, now published in Nature Cell Biology! 🎉

How do cells coordinate RNA processing with nuclear organization and the cell cycle?

https://t.co/Ztg7IA2MWV

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