❗New Open🔓Access Publication
🧪 Nicotinamide riboside treatment enhances stress sensitivity and modulates hematological dynamics in aged mice
👩🔬 By Luka Culig & Isabel Beerman (@BeermanHSCaging) et al.
This study shows that nicotinamide riboside (NR)—a widely studied NAD⁺ precursor—may ⬆️ stress sensitivity and affect 🩸 blood parameters in aged mice, highlighting the importance of context when considering NR as a longevity intervention.
📖 Read the full paper:
↪️https://t.co/fH5hkoDMRR
#NicotinamideRiboside #NAD #Aging #Stress #Anxiety #Hematology #Geroscience
@agingdoc1@hagayanay@GeroScienceAGE Thanks! We were also proud to report a resolution of “conflicting” DNA damage accumulation in HSCs during aging- we show mild proliferation stress can repair accumulated damage- while more extensive proliferation leads to accumulation of damage in HSC!
Thrilled to see our hard work on the cover of @CellStemCell! Exploring how cholesterol drives neurotoxicity in PMS iNSCs and showing potential for pharmacological rescue has been an incredible journey. Huge thanks to @Telencephale@Pluchinolab@dalessandrolab & our amazing team.
Congratulations to @hagayanay a fantastic postdoc on the job market: showed HSC divisional history is tracked by DNA methylation and correlates with function. Also beautifully resolves an outstanding question regarding DNA damage and HSC aging https://t.co/IDQpbv3YWB
Fantastic stem cell aging session closing out 2024 CSH mechanisms of aging conference- HSC biology had amazing representation by Danica Chen, Britta Will (and me!). Thanks to Shin Imai, Will Mair, and Meng Wang for all their hard work organizing this great meeting!
Don't miss the latest #SimplyBlood 🩸 blog post, featuring the ISEH 2024 Janet Rowley Award Winner, Dr. Robert Signer (@SignerLab). Dr. Signer shares his career path to becoming a PI, mentorship, and more! Read more on https://t.co/2NCQisaloN
Kudos to all the NIA summer interns for their hard work. Very proud of my high school intern Tasnim for earning a poster presentation award- she was a joy to have in the lab and we wish her the best for her Senior year!