Ben Lerch

Reversing aging will be the greatest achievement in human history.

[LongevityLab @LxngevityLab]

We could be the last humans to age and die on schedule.

One injection from David Sinclair's lab already made old, blind mice see again, and in 2026 the FDA cleared it for people.

Here's the science nobody's ready for (THREAD):

[Ben Lerch @BenLerch1]

@tunguz @nerdalert @growing_daniel Bookmark this

[Ben Lerch @BenLerch1]

@nerdalert @tunguz @growing_daniel Many people are saying

[Brian Armstrong @brian_armstrong]

Imagine you had the energy, metabolism, and mental agility of your younger self - without the aches and pains that come from aging.

That’s what we’re attempting to build at @NewLimit and it will be one of the most important achievements in human history ever if it works.

We're on the cusp of this being tractable given the rise of AI to test more hypotheses in-silico, along with the rapidly falling cost of single cell sequencing, etc.

We announced our Series C and upcoming human clinical trials this week, so still a long, long way to go, with many risks. But with hard work we've got a shot at making this a reality.

[SciTech Era @SciTechera]

A historic milestone for longevity science.

Today, the Life Biosciences team confirmed that the first patient has been dosed with ER-100, an epigenetic restoration therapy designed to rejuvenate damaged optic nerve cells and potentially restore vision.

This is an exciting milestone.

I believe therapies that restore cellular function, rather than simply manage symptoms, will define the neXt generation of medicine.

That's why this matters so much.

[Ben Lerch @BenLerch1]

@jordanreviewsit It’s a longevity hack because each day feels like an eternity

[Marcos Arrut @MarcosArrut]

Either we control the epigenome, or aging will kill us.
This is the most important fight of the century.

That's all.

[Laurie Green @LaurieGreen36]

David Sinclair plans to test whole-body rejuvenation drugs in the XPrize competition

https://t.co/vL3q9l9sm9

[David Sinclair @davidasinclair]

30 years of research came down to one moment. Was honored to be there. Congrats to the team! 👏

[Ben Lerch @BenLerch1]

David Sinclair on the Longevity Pill, Age Reversal Timelines, and Updated Protocols
https://t.co/TUoMTjryCr

[Brian Armstrong @brian_armstrong]

Aging is arguably the root cause of most major diseases. Our cells lose function as we age, allowing various conditions to manifest, which is why most major diseases correlate with age.

Yes, it is more complex than this, but this is a major component. @newlimit is working on treating a root cause of disease (aging) using epigenetic reprogramming.

[David Sinclair @davidasinclair]

Best article in years

[Lifespan @JoinLifespan]

In vivo reprogramming is becoming something much bigger than rejuvenating fast-aging mice or restoring eyesight 🚀

[Peter H. Diamandis, MD @PeterDiamandis]

Partial epigenetic reprogramming enters human trials THIS QUARTER (thank you @davidasinclair). Yamanaka factors targeting optic neuropathies -- next liver, after that your entire body! We're not preparing for the longevity revolution—we're IN it. Are you paying attention?

[Samuel Hume @DrSamuelBHume]

If you missed this study, it's well worth a look

Blocking the pro-inflammatory cytokine, IL11 (by deleting it, or with a therapeutic antibody) makes mice live healthier, for longer — and they look younger too

[Retro Biosciences @RetroBio_]

excited to share @OpenAI's latest blog post on our collaboration using gpt-4b to accelerate protein engineering, including our result where we rewrote the Yamanaka factors using our model, leading to drastic increases in reprogramming efficiency https://t.co/jYGdGabjkL

[vitrupo @vitrupo]

David Sinclair says we’ll find out this year whether aging is reversible.

His lab reversed biological age in animals by 75% in six weeks. The FDA has cleared the first human trial.

Aging may be information loss.

Information can be restored.

[Elon Musk @elonmusk]

@ashleevance Wow

[Ashlee Vance @ashleevance]

Not sure how I missed this, but it's freaking nuts. Altos Labs is hitting organs with Yamanaka factors ahead of transplants and basically making the organs younger, which in turn makes the transplant work better https://t.co/XVfGHFVbd7

[Elon Musk @elonmusk]

@aakashgupta Interesting