John Biggins

Senior Research Director - Chiari EDS Center ~ ... #hEDS #EDS #Chiari Lousy chess player. All opinions are my own

[John Biggins @BigginsSniggib]

New clinical research from the Chiari EDS Center of Mount Sinai South Nassau - outlining a protocol for standardizing the assessment of craniocervical instability downstream of connective tissue dysfunction/Hypermobile Ehlers-Danlos. #EDS #hEDS #CTD https://t.co/PM9am03rHt

[John Biggins @BigginsSniggib]

@DawsAngeles - Invented the roots rock genre
- Inspired Clapton to quit Cream
- Inspired George Harrison to make the greatest of all beatle solo albums

[John Biggins @BigginsSniggib]

@NikoMcCarty @rtnarch Student’s t-test was developed by William Seally Gosset at Guinness Brewery

[John Biggins @BigginsSniggib]

My annual Thanksgiving tweet 🦃

[John Biggins @BigginsSniggib]

What goes "gobble gobble" and binds DNA? An in-turkey-lator

[John Biggins @BigginsSniggib]

@BulwarkOnline @Timodc Tim Dillon is no MAGA podcaster. He is America’s sweetheart

[John Biggins @BigginsSniggib]

@R_H_Ebright We could have 100s of new abx in a month. All that is needed is a government backed Manhattan project support system.

[John Biggins @BigginsSniggib]

@therealjmers @ProjectLincoln Not-So-Slim Shady

[John Biggins @BigginsSniggib]

@remissionbiome Is this being recorded?

[John Biggins @BigginsSniggib]

@adamcarolla And it’s “pinas colada”.

[John Biggins @BigginsSniggib]

@garytaubes My “dirty lemonade” uses blackstrap molasses. The strength of the molasses taste cuts the bitter lemon so only a fraction of sweetness is needed to balance. Maybe about 1/3 the calories of normal lemonade.

[John Biggins @BigginsSniggib]

@GratefulDead @jerrygarcia @jayblakesberg I have to say, if Terry Kath survived, he’d give JG a run for his money, as he was planning his own solo side-project

[John Biggins @BigginsSniggib]

@ATinyGreenCell I thought the same. I started with the perfect one. I now have 50. Watches are an addiction.

[John Biggins @BigginsSniggib]

@RepCasten Uh how how how how

[John Biggins @BigginsSniggib]

@ATinyGreenCell Indigoidine expression. Cell turns purple

[John Biggins @BigginsSniggib]

@adamcarolla Phil Rizzuto was the voice and face of the NY YANKEES from the late 50s into the 1990s. He was one of the most famous New Yorkers & **everyone** knew him by name and voice, especially kids. He is the color commentator in Meatloaf’s “Paradise by Dashboard light”

[Emily Johnson (is on Mastadon and Bsky) @emily_rj]

New research via EDS Chiari Center

#EDS tied to many disabling syndromes like Chiari Malformation, Tethered Cord, #POTS and Dysautonomia, Mast Cell Activation Disorder #MCAD, Styloid Hypertrophy, Myalgic Encephalomyelitis-Chronic Fatigue Syndrome #MECFS

https://t.co/fr2wovGFwD

[John Biggins @BigginsSniggib]

4. Curiously, many without a CTD diagnosis present for Chiari malformation, despite a strong Chiari/EDS association.

[John Biggins @BigginsSniggib]

Please see the latest publication from The Chiari EDS Center of Mount Sinai South Nassau. The diagnoses and surgical demographics of over 700 patients were assessed, showing clear patterns among advanced hypermobility and autonomic/immune dysfunction 1/ https://t.co/t1SfMf0LWu

[John Biggins @BigginsSniggib]

3. Multiple disorders are strongly co-incident with advanced hEDS (eg., Chiari malformation, tethered cord, styloid hypertrophy (Eagle), POTS, MCAD, ME/CFS ..)

[Tess Falor, Ph.D. | Renegade Research @tessfalor]

N = 717!

"460 (64%) individuals were diagnosed with hEDS, 7 were diagnosed with a CTD other than hEDS, and 250 lacked a formal CTD diagnosis.

We found that individuals with hEDS had a higher frequency of certain comorbidities, such as Mast Cell Activation Disorder and Postural Orthostatic Tachycardia Syndrome, and neurosurgical intervention compared to individuals without a CTD diagnosis (unaffected).

Of the total cohort, 426 (59%) were diagnosed with Chiari I Malformation, which shared a significant overlap with hEDS. Of those who elected to undergo surgery (n = 612), 61% required craniocervical fusion (CCF). Notably, of the 460 individuals diagnosed with hEDS, 404 chose surgical intervention, of which, 73% required CCF for craniocervical instability."

#MEspine #MEspine24 #MEspine25 #hEDS #EhlersDanlos

[Karen Lubell @karenlubell]

New study from Ruhoy and Bolognese et al that examines the neurosurgical diagnoses for those with hEDS over 2014-2023. Fantastic! Haven't read it all yet, just skimmed, but includes Chiari, TC, CCI, MALs styloid hypertrophy, and more. 👏👏👏. Thank you Dr. Ruhoy.

[John Biggins @BigginsSniggib]

#EDS #EhlersDanlos #Chiari #MECFS

[John Biggins @BigginsSniggib]

Insights:
1. Craniocervical instability is clearly downstream of advanced hypermobile EDS, often neccesitating surgical fusion
2. Strong evidence supporting the associations among hypermobility, autonomic dysfunction, and immune dysfunction 2/