#ResultatScientifique 🔎 Grâce à l’IA, les scientifiques peuvent désormais analyser automatiquement la forme et la structure des mitochondries avec une précision inédite !
✍️ Mathieu Vigneau et Jean-Philippe Pradère
📕 @NatMetabolism | https://t.co/c4K8juLs7o
Get ready to meet the new isoform of MFN2, which is by far the most abundant MFN expressed in the central nervous system. It was hiding well, but we manage to track it down. Big thanks to Claudine David for this stellar work before her retirement, and to all the collaborators
Want to know more about cardiac aging, mtDNA mutations, mitochondrial dynamics alterations and their links to senescence and inflammation? Check our latest review in Mechanisms of Ageing and Development: https://t.co/TMglbTpXih
We are excited to share our latest work on mechanisms that protect from mitochondrial dysfunction. Thank you to all collaborators and the 4th anonymous reviewer for supporting us. @labs_mann@NatureComms@metaboflo
https://t.co/xLNyW00oil
We have 1-2 PostDoc positions for enthusiastic researchers interested in mitochondrial biology. Apply here. #mitochondria#mitojobs
https://t.co/tOv2e05PHF
New study from us:
https://t.co/GioeqFmsKo
High mtDNA copy number promotes lung cancer growth in the mouse, whereas mtDNA depletion in tumor cells reduces tumor growth. This tumor-intrinsic role for mtDNA can be exploited for development of future lung cancer therapies.
BREAKING NEWS
The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
News and Views from us on maternal transmission of mtDNA:
https://t.co/ubooY96MwB
In addition to the bottleneck mechanism and purifying selection in early oocyte development, elegant experiments show that purifying selection also occurs during postnatal mouse oocyte development.
New paper from us on the in vivo role of the LRPPRC/SLIRP protein complex and its crucial role in mammalian mtDNA gene expression:
https://t.co/qDhEd7WCtN
Congratulations @RubalDiana for great work! Thank you to all coauthors for a very nice collaboration.
A KI study published in @NatMetabolism today shows that a specific class of drugs that block mitochondrial function can reverse diet-induced #obesity, fatty liver and #diabetes in mice. #metabolism https://t.co/OOtT0zOYTQ
Read our new study: https://t.co/o6WNyQI38n
Treatment of obese mice with small molecule inhibitors of mtDNA transcription (IMTs) leads to marked beneficial metabolic effects. The weight is normalized, the fat deposition in liver disappears and glucose homeostasis is normalized.
Le Service d’Analyses Métaboliques (SAM) de @TBMCore est une plateforme spécialisée dans la quantification de métabolites.
Elle vient de se doter d’un nouvel équipement de pointe.
https://t.co/vsP2zE4Zxe