John Goertz

Founder, CSO, & PCRchitect @SignaturBio (YC S22) teaching machine learning to molecules. Prev @ImperialCollege, @UMDBIOE, @SeattleU. Podcast junkie! He/him

[John Goertz @BioGoertz]

📢Big News📢 I'm beyond excited to announce the launch of @SignaturBio and my new role as CSO!

We've got a radical new way to design nucleic acid diagnostics. Check out the link to learn more!

Now, I never saw myself as an entrepreneur. Here's a🧵on my leap from academia...

1/

[Signatur Biosciences @SignaturBio]

Hello world! We are Signatur Biosciences.

Spun out from @imperialcollege and backed by @ycombinator, we're reimagining molecular diagnostics to make precision medicine accessible around the world.

More about who we are and what we're up to👇

[John Goertz @BioGoertz]

@ltronneberg @ManuelaZucknick @RESCUER2020 @pauldwkirk I am curious, you constrained your model to output viability between 0 and 100% viability, but because of experimental noise your observations sometimes showed >100% viability. How did you account for that? Simple clipping of the observations?

[John Goertz @BioGoertz]

@ltronneberg @ManuelaZucknick @RESCUER2020 @pauldwkirk Great presentation! The simple construction of the permutation-invariant kernel was very clever.

[Devika Thapar @DeeThapar]

Alright, we hiring!

Who wants to support the next generation of scientist entrepreneurs?

At @wilbe_science, we are tackling the REALEST of problems and bringing science innovation and impact to the world.

And we are hiring 🤠 https://t.co/QGQZqveQEE

Please share!

[John Goertz @BioGoertz]

With all the environmental catastrophes we face, it's so important to remember that we have the power to fix things, to restore the balance we destroyed.

The re-introduction of wolves to Yellowstone is a great example. Also: humpback whales.

[Dr. Clayton Forrester @DrClaytonForre1]

In 1995, 14 wolves were released into the wild in Yellowstone National Park. Scientists at the time did not suspect that this would radically change the entire ecosystem of the park. 1/n

[John Goertz @BioGoertz]

I've lived this nightmare more times than I care to count...

[Guy R @grohkin]

woke up from a nightmare where I'm pipetting a 384 well plate, blank out for a second and can't tell whether I put 0.2uL of enzyme in, panicked, put the tip into another well and contaminate it. then when i look i cant tell if there's liquid in it cuz the volume is too small?!

[John Goertz @BioGoertz]

@RuxandraTeslo Sure, there are shared/cultural/ancestral experiences. My "lived experience" of 9/11 is where I was on that day, but my cultural experience, which is actually how I perceive 9/11, is much broader. Historical trauma or pride can also be experienced personally, though not lived.

[John Goertz @BioGoertz]

@RuxandraTeslo @SignaturBio @ycombinator Thanks Ruxandra!

[John Goertz @BioGoertz]

@nathanbenaich @DevyceUK, perhaps? Not sure if they do personal, yet.

[John Goertz @BioGoertz]

I swear there is no more obnoxious Twitter thread habit than the final tweet telling me to like the first tweet... I mean, come on, we all know how Twitter works 🙄

[John Goertz @BioGoertz]

Anyone know why recent Covid variants haven't been named? Why are we on variants-of-variants-of-Omicron instead of just the Psi variant? BA.5 and BA.2.75 must be different enough to warrant categorization as new strains.

[John Goertz @BioGoertz]

@Charles_Mace @SignaturBio Thanks, I'm excited to find out too!

[John Goertz @BioGoertz]

📢Big News📢 I'm beyond excited to announce the launch of @SignaturBio and my new role as CSO!

We've got a radical new way to design nucleic acid diagnostics. Check out the link to learn more!

Now, I never saw myself as an entrepreneur. Here's a🧵on my leap from academia...

1/

[Signatur Biosciences @SignaturBio]

Hello world! We are Signatur Biosciences.

Spun out from @imperialcollege and backed by @ycombinator, we're reimagining molecular diagnostics to make precision medicine accessible around the world.

More about who we are and what we're up to👇

[John Goertz @BioGoertz]

@MartinaCihova @SignaturBio Thanks Martina!

[John Goertz @BioGoertz]

@sebacallens @SignaturBio @CelestindeWer Thanks Sebastien!

[John Goertz @BioGoertz]

@baalturkestani @SignaturBio @CelestindeWer Thanks Bayan! Can't wait to hear how Conan's been doing!

[John Goertz @BioGoertz]

So that's how I went from academia-bound postdoc to entrepreneur. Feel free to reach out if you're considering the same thing, happy to chat!

And follow @SignaturBio for more about the company. We'll be hiring soon! https://t.co/gWsDX4tSJm

[John Goertz @BioGoertz]

So, the three of us started building the company. Refining the strategy, measuring the market, perfecting the pitch (or, really, making it barely passable). Now, many VC pitches later, we're in @ycombinator 's S22 batch. What a way to start!