Blazek lab

Regulation of gene expression and cyclin-dependent kinases

[Blazek lab @BlazekLab]

Our work on role of CDK11 in pre-mRNA splicing is out in @Nature. Congratulations to @MilanHluchy and Pavla Gajduskova and everybody in the team - great collaboration with Friedel, Paruch, Knapp, Zdrahal and @ule_lab labs. https://t.co/EtySR6WyMO 🧵1/8

[David López Martínez @davidlopmar]

Really excited to share my preprint describing a novel activation mechanism of CDK12/13 by the PAF1 complex essential for transcription elongation! https://t.co/x2SXMsOFma

[Igor Ulitsky @IgorUlitsky]

A 1,000,000th reminder the crucial importance of basic research. Ambros and Ruvkun were looking into understanding nematode genetics and development, not looking for a drug, and ended up opening an entire new area in biology

[Hana Sedlackova @HanaSedlackova1]

📢For all HaloTag lovers💙💚❤💜🤍 we developed a new cell-permeable Biotin-HaloTag ligand enabling rapid protein labeling in living cells and efficient streptavidin pull-down. We hope you enjoy the reading and find some inspiration🙌 https://t.co/LIbONhRKde

[Trends Cell Biology @TrendsCellBio]

CDK11, a splicing-associated kinase regulating gene expression https://t.co/H6g3dQXxR8

[Blazek lab @BlazekLab]

Our review about CDK11 is out in @TrendsCellBio now.
We discuss evolution of CDK11 - SF3B1 axis and its role in pre-mRNA splicing. We also summarize how CDK11 and its inhibition affect transcription and cell cycle progression.
Free access here: https://t.co/1kqzXe0u49

[Itai Yanai @ItaiYanai]

The 90/10 rule of scientific discovery: 90% of your results come from 10% of your explorations, but it's not possible to know in advance what specific explorations those will be.

[Petr Svoboda @SvobodaLab]

PhD student's desires, demands, and ambitions ride on the same car with PI's needs (and fears) of (not) producing enough results for sustainable funding and long term survival of a lab.

[DIANA Biotech @DianaBiotech]

👋 Meet us at @SLAS_Org!

Enjoying the event with @IKalasova and Lucia Bialesova! Feel free to reach us and talk about our brand new DIANA Cyclin Dependent Kinases (CDKs) panel based on our unique DIANA Technology!

We'll be also ready for you at the poster session B tomorrow at 10:30 🙌 We are looking forward to every question you have!

🔬 Key Highlights:

Selective Profiling: We’ve successfully profiled target compounds against 24 Cyclin Dependent Kinases (CDKs), providing crucial data to further our understanding in this area.
Innovative Development: Exciting progress on further development of our DIANA General Kinase Panel kinase that will cover the entire human kinome, enhancing our capability to tackle complex diseases.

🌟 Main Features of DIANA:

Proprietary Technology: Leveraging our patented DIANA technology.
High Throughput: Utilizes a 384-well plate format to accelerate outcomes.
Cost Efficiency: Reduced reagent consumption makes this method not only innovative but also cost-effective.
Precision: Quantitative PCR-based readout allows for determination of inhibition constants (Ki) from a single well.

For more info: https://t.co/TB10HdjN5Z

#DrugDiscovery #Innovation #DIANATechnology #PharmaIndustry #SLASEurope2024

[Blazek lab @BlazekLab]

vyborny rozhovor

[VědaVýzkum.cz @vedavyzkum_cz]

👨‍🔬Patrick Cramer působí jako prezident Společnosti Maxe Plancka.
❓Proč si @maxplanckpress vybrala po Polsku ČR, kam program Dioscuri rozšířila? Co si od center na @FZU_AVCR a @muni_cz slibuje? A co podle něj brzdí vědu v Evropě?
Čtěte v rozhovoru:
👉https://t.co/pO1koYcs32

[Patrick Cramer @mpgpresident]

Looking forward to give the Mendel lecture tomorrow in Brno, Czech Republic, the birthplace of genetics.
https://t.co/rWAgDvd2d7

[Učená společnost ČR @ucena_spol]

Prof. Julius Lukeš z Parazitologického ústavu Biologického centra AV ČR, člen Učené společnosti ČR, byl jako třetí Čech zvolen zahraničním členem americké Národní akademie věd (NSA).
🔹https://t.co/oren4b8r22
Blahopřejeme!

[Itai Yanai @ItaiYanai]

George Church summarizes the power of the mentee-mentor team in this fun podcast episode ‘what's nice is if you combine the experience of an adult, even a senior adult, with the attitude of a child, that's far better than either one of them separately.’
https://t.co/XEh8jHLWOr

[Johannes Walter @FrogWalterLab]

A warm thank you to Lumír Krejčí for hosting my Mendel lecture in Brno, Czech Republic, home of a vibrant scientific community, the marvelous Tugendhat Villa, and of course, Gregor Mendel. To stream Mendel lectures: https://t.co/NUJ1nQQUKM

[Jan Hejatko @hejatko]

Great talk of prof. Thomas Cech, the Nobel prize winner for the discovery of RNA enzymatic activity in the Augustinian Abbey in Brno @MendelBrno .

[Ernst Schmid @ernstschmidd]

My work in Johannes Walter’s lab on developing a classifier to score AF-multimer predictions (alongside a large scale screening effort) is out as a preprint now! https://t.co/9uNgGuNIgo @Johanne23743184

[Matjaž Barborič @BarboricLab]

Doctoral student position open in our lab @helsinkiuni @LifeSciHelsinki @HelsinkiUniMed Are you interested in RNA Pol II @generegulation, transcriptional cyclin-dependent kinases, and how these could be targeted in cancer? Apply by April 5th: https://t.co/rPIZ2g7hHA Please RT

[Itai Yanai @ItaiYanai]

How the project happens –– How we write the paper

[Karel Riha @karlriha]

We are looking for a PhD student in Plant Biology https://t.co/a2lPnVA0ji Topics: RNA-protein biocondensates & plant reproduction & stress response; plant centromeres & heat stress @CEITEC_Brno PLs retweet

[Petr Svoboda @SvobodaLab]

After three years, I open a PhD position! Negotiable topic - either the molecular mechanism of miRNA biogenesis & its evolution or RNA silencing pathways in molluscs, as an underexplored case of convergent evolution of RNA silencing. Benchwork or bioinformatics or both. RT pls!

[Hana Sedlackova @HanaSedlackova1]

A postdoc position is available in our lab 🔬. If you are interested in DNA replication & genome stability, please get in touch. Thank you for sharing! More information also here: https://t.co/jjvaN6oJpf