Dan Blears

Transcription mechs and gene expression regulation enthusiast. UCL / Crick PhD student based at UCPH in the Svejstrup lab

[Patrick Cramer @mpgpresident]

Great to see how Integrator embraces the paused transcription complex to engage with nascent RNA and trigger Pol II attenuation. Paper by @isaac_fianu et al. edited by @dijiang319 is out @ScienceMagazine:
https://t.co/hx8rb9Awly

[Dan Blears @BlearsDan]

PhD student wanted! Join the Svejstrup lab in our endeavour to understand the mechanisms of gene transcription and the transcription-DNA damage interface #RNAPII #UCPH 🧬🧩 https://t.co/SkmGHBHawS

[Dan Blears @BlearsDan]

This massive box and 14 ice packs for 50ml of stripping solution? Crazy world @fishersci

[Lea Haarup Gregersen @GregersenLab]

We are hiring a PhD and postdoc!👩🏻‍🔬👨🏽‍🔬 Are you interested in transcription and RNA biology?🔬🧬 The come join us at @uni_copenhagen. Find out more about our research:  https://t.co/RIYYfkOn7p, the PhD https://t.co/TOpYPCqqLh and postdoc position https://t.co/BmBgXDj5RL. Please RT!

[Tristan Croll @CrollTristan]

There's (quite rightly) a lot of raving about the new AlphaFold DB resource today. Thought I'd weigh in with my own example. DNA-dependent protein kinase catalytic subunit (https://t.co/Y0462LUdMy) is an enormous beast - a single chain of 4,128 residues! (1/10)

[Dan Blears @BlearsDan]

@Li_Wan88: Scientific mentor, fellow consumer of Guinness and "unstoppable force of nature" in the words of JQ Svejstrup. Thanks for the support and opportunity to contribute to this awesome work on how cGAS senses translation stress.
https://t.co/KRCHek131t

[Matt Henderson @matthen2]

a large image of hundreds of flocking birds contains enough information to create an animation of a single bird flying

[DNA&RNA Universe 𝕏 @DNA_RNA_Uni]

Fidget centrifuge for a simple spindown
#labhacks 😎

[Apoorva Baluapuri @Pol2Runner]

#EESGenomeInstability Jesper Svejstrup had recently summarized the challenges that Pol II overcomes during trancription in a beautiful review @NatRevMCB together with @MNoeGonzalez and @BlearsDan. Have a looksies: https://t.co/zctU09T54C

[Dan Blears @BlearsDan]

@OdedRechavi @davidlopmar @MNoeGonzalez

[Dan Blears @BlearsDan]

Did the aquatic to terrestrial transition involve a fish growing arms and crawling out of sea? Well sure enough, Zebrafish have the capacity to develop arm-like structures. What about legs?

[Cell @CellCellPress]

Out now! Simple #genetic perturbation causes the formation of #limb-like bones in the pectoral fins of #zebrafish. These new bones integrate into #musculature, form joints, and articulate with neighboring elements https://t.co/5113RCAjzG 🐟💪

[Roberta Migale @DrMigaleRoberta]

📢@TheCrick is officially a vaccination centre! This is our first week and it's been excellent! We've already vaccinated hundreds of healthcare/social workers & vulnerable people Well done to ~300 volunteers and the amazing
@NHSuk @uclh staff helping us #CovidVaccine #vaccine 💙

[Oded Rechavi @OdedRechavi]

BREAKING: President Biden signs an executive order banning validation of RNA-seq results with Real-time PCR

[Nature Reviews Molecular Cell Biology @NatRevMCB]

Great read!

#Review by Jesper Svejstrup and co outlining causes and consequences of RNA polymerase II stalling

@TheCrick

#transcription #PolymeraseII #GenomeIntegrity

https://t.co/Z8xKRTnBht

[Eric J Wagner @Wagnerlab_RNA]

Unbelievable Achievement: Structure of the Integrator-PP2A complex reveals its CTD phosphatase activity is a general suppressor in transcriptional regulation!! https://t.co/lHdlQawJFt

[Lea Haarup Gregersen @GregersenLab]

Excellent review hot of the press by @MNoeGonzalez and @BlearsDan on stalling of RNA polymerase II 🧬 and its implications for transcription

[Dan Blears @BlearsDan]

Our review is out! We discuss why RNAPII get's stuck during elongation and associated transcriptional outcomes. It's been a pleasure working with @MNoeGonzalez on this. Thanks to @NatRevMCB and reviewers; I've learnt a huge amount from everyone.

[Nature Reviews Molecular Cell Biology @NatRevMCB]

Now Online Causes and consequences of RNA polymerase II stalling during transcript elongation https://t.co/oMDTPRgZjV