Bo Peng

A father. Distinguished Professor at Fudan University. Neuroscientist. 𝗠𝗶𝗰𝗿𝗼𝗴𝗹𝗶𝗮 𝗿𝗲𝗽𝗹𝗮𝗰𝗲𝗺𝗲𝗻𝘁, repopulation, aging & microglia in anesthesia.

[Bo Peng @BoPengMicroglia]

We are proud to share our latest study published in Science. After achieving efficient and clinical feasible microglia replacement for the first time in 2020 (PMID: 32783928), we applied this strategy to treat a severe and fatal neurological disease, ALSP, and observed remarkable therapeutic effects—not only in the mouse model, but also in clinical trials involving 8 individuals with ALSP and up to 24 months of follow-up. This marks the first-in-human clinical application of microglia replacement therapy and suggesting its therapeutic effects in more neurological diseases.
Check out the study at https://t.co/fXG6oQ08ni

[Bo Peng @BoPengMicroglia]

@TheColonnaLab @ScienceMagazine @khainotkaiorky Amazing study! Big congrats!

[Bo Peng @BoPengMicroglia]

I’m happy to be formally selected as the category winner in neuroscience for the 2026 𝗧𝗮𝗸𝗲𝗱𝗮 𝗜𝗻𝗻𝗼𝘃𝗮𝘁𝗼𝗿𝘀 𝗶𝗻 𝗦𝗰𝗶𝗲𝗻𝗰𝗲 𝗔𝘄𝗮𝗿𝗱 𝘄𝗶𝘁𝗵 𝗡𝗮𝘁𝘂𝗿𝗲 @TakedaPharma @Nature, in recognition of my pioneering contributions to 𝗺𝗶𝗰𝗿𝗼𝗴𝗹𝗶𝗮 𝗿𝗲𝗽𝗹𝗮𝗰𝗲𝗺𝗲𝗻𝘁.
https://t.co/h0kYXLRPX1

[Bo Peng @BoPengMicroglia]

Thank you for sharing our microglia replacement study! In 2020, we achieved efficient microglia replacement for the first time (PMID: 32783928). After that, we took another 5 five years to demonstrate its clinical feasibility and efficacy (PMID: 40638739). We truly believe that microglia replacement holds far-reaching potential for treating a wide range of neurological diseases. Let’s change the world and make this happen!

[Bo Peng @BoPengMicroglia]

@jonykipnis @DuSiling @TheColonnaLab Congrats!!!

[Bo Peng @BoPengMicroglia]

I’m happy to be selected as a shortlisted finalist in neuroscience for the 2026 𝗧𝗮𝗸𝗲𝗱𝗮 𝗜𝗻𝗻𝗼𝘃𝗮𝘁𝗼𝗿𝘀 𝗶𝗻 𝗦𝗰𝗶𝗲𝗻𝗰𝗲 𝗔𝘄𝗮𝗿𝗱 𝘄𝗶𝘁𝗵 𝗡𝗮𝘁𝘂𝗿𝗲 @Takeda @Nature, in recognition of my pioneering contributions to 𝗺𝗶𝗰𝗿𝗼𝗴𝗹𝗶𝗮 𝗿𝗲𝗽𝗹𝗮𝗰𝗲𝗺𝗲𝗻𝘁.
This award celebrates groundbreaking research by early career scientists who are advancing the frontiers of scientific discovery in the areas of gastrointestinal and inflammatory diseases, neuroscience, and oncology. Takeda will award three category winners – one from each area of focus – in February, and one grand prize winner in April.
I’m honored to receive this recognition and I’m excited to participate in Nature’s career development programs, while building meaningful connections with my peer awardees.
https://t.co/h0kYXLRPX1
https://t.co/rPJVh1IbTM
https://t.co/UZOCkxr7eJ

[Bo Peng @BoPengMicroglia]

@ShellyFan AI may replace us some day in the future. Before that, we have already been able to replace our microglia 😀

[Bo Peng @BoPengMicroglia]

We are delighted to share our newly published Perspective review on microglia replacement in Cell Stem Cell @CellStemCell. This comprehensive article provides an in-depth overview of most key aspects of microglia replacement, including its concept, history, mechanistic principles, implementation strategies, relevant microgliopathies, applications, clinical trial, and future directions.
We hope this review serves as a valuable resource for the community of microglia biology, neuroimmunology, and cell therapy.
Find the full article here:
https://t.co/IuEm5SekYu

[Bo Peng @BoPengMicroglia]

Latest Nature News of microglia replacement.
Swapping old immune cells in the brain with fresh ones could treat disease https://t.co/lGQbeh6mw3

[Bo Peng @BoPengMicroglia]

Thank you for sharing our microglia replacement study! In 2020, we achieved efficient microglia replacement for the first time (PMID: 32783928). After that, we took another 5 five years to demonstrate its clinical feasibility and efficacy. We truly believe that microglia replacement holds far-reaching potential for treating a wide range of neurological diseases. Let’s change the world and make this happen!

[Bo Peng @BoPengMicroglia]

Thank you for sharing our microglia replacement study! In 2020, we achieved efficient microglia replacement for the first time (PMID: 32783928). After that, we took another 5 five years to demonstrate its clinical feasibility and efficacy. We truly believe that microglia replacement holds far-reaching potential for treating a wide range of neurological diseases. Let’s change the world and make this happen!

[Nature Biotechnology @NatureBiotech]

Research Highlight: Microglia replacement halts rare brain disease progression https://t.co/bPTmpHMyz6

[Bo Peng @BoPengMicroglia]

Microglia to the Rescue | Science | AAAS https://t.co/fm5Vbrxb4R

[Bo Peng @BoPengMicroglia]

Thank you for sharing our microglia replacement study! In 2020, we achieved efficient microglia replacement for the first time (PMID: 32783928). After that, we took another 5 five years to demonstrate its clinical feasibility and efficacy. We truly believe that microglia replacement holds far-reaching potential for treating a wide range of neurological diseases. Let’s change the world and make this happen!

[Bo Peng @BoPengMicroglia]

Thank you for sharing our microglia replacement study! In 2020, we achieved efficient microglia replacement for the first time (PMID: 32783928). After that, we took another 5 five years to demonstrate its clinical feasibility and efficacy. We truly believe that microglia replacement holds far-reaching potential for treating a wide range of neurological diseases. Let’s change the world and make this happen!

[Bo Peng @BoPengMicroglia]

Thank you for sharing our microglia replacement study! In 2020, we achieved efficient microglia replacement for the first time (PMID: 32783928). After that, we took another 5 five years to demonstrate its clinical feasibility and efficacy. We truly believe that microglia replacement holds far-reaching potential for treating a wide range of neurological diseases. Let’s change the world and make this happen!