BogunovicLab

Studying human immunogenetics to unveil new biological paradigms explaining susceptibility to infection and/or inflammation. #children #immune defects #genetic

[BogunovicLab @BogunovicLab]

😊👇🏼

[Journal of Human Immunity @jhumimmunity]

🔔 We're delighted to share the Abstracts from the Serbian Group for Primary Immunodeficiencies (SGPI) 2nd symposium, which took place April 24-25 in Belgrade and Novi Sad, Serbia. Explore the latest advancements in #PID clinical practice and research! 👉 https://t.co/hCywiG6g1h

[BogunovicLab @BogunovicLab]

Latest from us. :)

[Journal of Experimental Medicine @JExpMed]

Conor Gruber, @BogunovicLab @KidsAtColumbia et al. identify #STAT2 mutations in a family with severe early-onset pulmonary alveolar proteinosis (PAP), a rare lung disease marked by alveolar surfactant accumulation. https://t.co/SZMgiAAJ9a

[BogunovicLab @BogunovicLab]

An exquisite article in The Atlantic by @rkhamsi on how fatal genetic diagnosis need not be. Thank you for featuring @BogunovicLab. 👇🏼 https://t.co/rXTWREZEEW

[BogunovicLab @BogunovicLab]

Latest from us. :) Led by amazing Pat O’Connell. We, more often than not, see variants of unknown significance (VUSs), and by definition don’t know if they are causative of disease. The only way to exclude them as causative is to test them experimentally. https://t.co/Ht64HZnx3k

[BogunovicLab @BogunovicLab]

The Best Father’s Day gift. 🤣 wishing a happy one to all.

[BogunovicLab @BogunovicLab]

Latest from us. Led by amazing Azzeddine Tahiat. Novel forms of CD55 deficiency. Importantly, C5 inhibition restores B cell homeostasis #CHAPLE disease @KidsAtColumbia @ColumbiaPS @Columbia https://t.co/kCLsKKHSZX

[BogunovicLab @BogunovicLab]

Latest from us. @MelissaGansMD et al. lead the way in detailing how best to care for immune dysregulation in individuals with Down syndrome. @jhumimmunity https://t.co/iyXy2crgaT

[BogunovicLab @BogunovicLab]

Latest from us. Led by @he_randolph. What goes rogue in #MISC? 1) Although clinically silent, inflammation persists for months! 2) This is in part due to expansion of T cells that recognize SARS-CoV2 antigens but also cross-react to self antigens. 👇🏼 https://t.co/UFHN1UK803

[BogunovicLab @BogunovicLab]

This is funny and true. :)

[Casanova Lab @casanova_lab]

1/ Spotlight on our former trainee Dusan Bogunovic (@BogunovicLab), a postdoctoral fellow in our NY lab from 2010-13 and now Professor of Pediatrics, Vice Chair for Basic Research, and Director of the Center for Genetic Errors of Immunity at @Columbia.

[BogunovicLab @BogunovicLab]

A must read!

[Journal of Human Immunity @jhumimmunity]

In this Perspective, Casanova @casanova_lab discusses the 30-year history and future implications of emerging science showing that monogenetic lesions, and #autoimmune disorders targeting the same components of host defense, can underlie the same infection https://t.co/dT4p8hLslD

[BogunovicLab @BogunovicLab]

Latest thoughts. Today in @JExpMed. We are disomic individuals genetically. Transcriptionally we need not be. Here I discuss what we know about this and propose Theory of Personal Evolution. @KidsAtColumbia @ColumbiaMed https://t.co/zTLo7lZ6gB

[BogunovicLab @BogunovicLab]

@drdeannasanter Thank you 🙏🏼 🙏🏼🙏🏼

[BogunovicLab @BogunovicLab]

Join our study using next generation Jak inhibitors in skin diseases in individuals with #DownSyndome with @EmmaGuttman @MSHSDerm and @BogunovicLab @KidsAtColumbia. We are actively recruiting. https://t.co/XnhaRayB5n

[BogunovicLab @BogunovicLab]

With his greatness. Honoring his greatness. Thank you @Cornell for invitation to Carl Nathan Lectureship. It was wonderful.

[BogunovicLab @BogunovicLab]

When in Rome… Thank you ImmunITA for hosting me. And thank you for listening to my theory. @KidsAtColumbia @ColumbiaMed

[BogunovicLab @BogunovicLab]

My favorite meeting is back in NYC. Come join us!!!

[Casanova Lab @casanova_lab]

1/ The 33rd Annual Henry Kunkel Society Meeting will be held April 16–18, 2026, at @RockefellerUniv in New York. The theme is “Autoantibodies Against Cytokines.”

[BogunovicLab @BogunovicLab]

Latest from us👇🏼 😀 #fibrosis #interferon type I #apoptosis #woundhealing #ISG15deficiency

[Journal of Human Immunity @jhumimmunity]

Sazeides et al. @BogunovicLab show that human ISG15 deficiency is a monogenic syndrome that poises individuals to a proapoptotic and profibrotic state that can lead to lung and skin damage with scarring and impaired function via chronic inflammation. https://t.co/by0OxP0erN

[BogunovicLab @BogunovicLab]

Latest from us. @columbiaMed @KidsAtColumbia Dr Akalu et al. report on novel variants leading to TBK1 deficiency , resulting in autoinflammation but also in some cases viral diseases. https://t.co/ykQhAEBr9e

[BogunovicLab @BogunovicLab]

@canna_lab @DangitVinh @AFKamenetskii @zachlanzar @aaronmring @simchatx @KingOfPathogens Very nice!

[NY-CURES @NYcures]

We’re very close, and when we reach 2000 signatures, petition will be sent to @GovKathyHochul ahead of her Executive Budget announcement and revision period throughout January! So share with friends & family! https://t.co/6d73vmzQIn