📚 𝐅𝐨𝐜𝐮𝐬𝐞𝐝 𝐑𝐞𝐯𝐢𝐞𝐰
"How to frustrate a plant pathogen" 🐛
This review explores new strategies for engineering broad-spectrum resistance against plant pathogen effectors.
✍️ Knight, Heddle, and @adamrbentham
👉 https://t.co/2NBSnrLwss
Excited to share our new review.
Natural small RNA-based defense informs engineering of host-induced gene silencing in plant disease resistance - ScienceDirect https://t.co/5Hgfrpd2By
Help early-career researchers get to Jeju! 🙏
The Mishkind Fund supports students & postdocs attending the IS-MPMI Congress. We've raised $23,500 toward our $40,000 goal!
Every donation makes a difference. Contribute at https://t.co/MG3dMXQVCi
Please RT/repost! 🔁
New work out in @ScienceAdvances! We show how excess nitric oxide alters cellular pH to restrict salicylic acid movement and block systemic immunity in plants.
Read the full study here: https://t.co/gkFgJ3EUQF
Check out our paper in the @PNASNews Special Feature: https://t.co/BXdoXdESVK. We explore how stress induces polyploidy across fungi, plants, and animals, reshaping genomes, cells, and tissues through cell cycle alterations. Great collaboration with @FoxLabNC and @AnnaSelmecki
Q: What is the cargo?
A: This was a real surprise. EDS1, a key protein regulating immune cell death in plants. EDS1 mutation almost completely rescues the autophagy mutant phenotype.
Today we're announcing ESMFold2, an open scientific engine to power prediction, design, and discovery across protein biology.
The new model delivers state of the art performance on protein interactions, especially antibodies, a critical modality for therapeutics.
We have designed and validated miniprotein binders and single chain antibodies across five therapeutic targets that are important in cancer and immunology. We are seeing very high success rates, and affinities at levels consistent with therapeutic activity.
We’re also releasing an atlas of 6.8 billion proteins, and 1.1 billion predicted structures.
ESMFold2 is built on a state of the art language model that has been trained on billions of protein sequences.
A world model of protein biology emerges through language modeling.
We’ve used the techniques of mechanistic interpretability developed to understand large language models to understand the concepts ESM uses to represent proteins.
The model’s representation space has a compositional organization of features across scales, levels of complexity, and abstraction, that reflects and mirrors the understanding of protein biology developed through a century of empirical science.
This understanding emerges without prior knowledge, just from language modeling of protein sequences.
Language models are becoming a powerful substrate to understand and program biology.
The design of protein interactions is one of the most fundamental problems in biophysics, and has critical implications for the discovery of new medicines. A simple gradient based search with the model was able to discover high-affinity protein binders.
I'm excited by the potential this has to accelerate basic science and the understanding of proteins. And especially for the new avenues it opens up for therapeutic design and medicine.
Excited to share our newly published "A Multidimensional View of Biomolecular Condensates in Plant Biology" in the Annual Review of Plant Biology!
We discuss emerging mechanisms, biological functions, and future directions. 🌱🔬 - https://t.co/qTpzGvG3Mv
A new preprint is OUT! 🚨
Thrilled to finally share our work on how decoy diversification underpins the regulation of an NLR-mediated autoimmunity.
Check out the full story on @bioRxiv: https://t.co/7gpHvUDqN0
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📢 The next @MPMIjournal Focus Issue is now open for submissions: "Plant Immune Receptors in the Spotlight" 🌱🔬
Edited by @sardineboy_DING@ClemMarchal@MariSchuster@WilsonLab and yours truly!
Deadline: Oct 31, 2026 Submit your best work! 👇 https://t.co/As0i2pbyWS
Protein structure prediction changed biology. Protein assembly discovery is next.
We present SNI (Structural Novelty Index), a scalable framework for finding new protein complexes.
We used it to uncover an unexpected resistosome assembly: 11-mer. 🧵👇🏻
https://t.co/bCADVEnE6b
Featuring rare books and historical records that date as far back as 1531, explore 150 years of the Singapore Botanic Gardens Library at the ‘Roots of Knowledge’ exhibition. 📚
Catch the exhibition from now till 1 Jun 2026, 9am – 6pm, at the Botanical Art Gallery!
Proud to share our MS from @Freddie_King00 & Juan with the @AdamWu9527 & @lderevnina labs! AS109-mediated agroinfiltration enables transient expression across non-model plants and positions faba bean as a tractable system for studying disease-resistance https://t.co/QIjVw2Zwj6