Another demonstration of the importance of studying target tissue. We had found a clonal T cell population in the skin (and not found in the blood) in this complicated case of anti-synthetase syndrome.
This case report describes the clinical course of a 32-year-old woman with anti-synthetase syndrome presenting with angioedema-like panniculitis and subsequently cutaneous ulcers, synovitis, and fevers, found to have a clonal TCR-beta gene rearrangement. https://t.co/mXbNmmHjY0
@Janetbirdope@RheumNow Thanks for the shoutout on the #Sjogrens study. Agree that this antibodies don’t tell the whole story and even this cohort didn’t have a lot of longterm serial biopsy data. More studies looking at early disease are needed.
I only started my lab a little over 4y ago as an Instructor @harvardmed@MGHHeartHealth with a new K08 award in hand.
4 R01 awards as PI later, here's what I've learned as a physician-scientist:
#ACR21 Rheumatology Secrets & Pearls: @JKolfenbach & Dr. Stone 📚
Unique Pearls Discussed ⬇️
🩺 Auscultate bruits on the back
💊 Oxypurinol levels
🍓 Strawberry-like gingivitis
👃 Human neutrophil elastase (HNE)
♥️ Coronary aneurysm in IgG4-RD
@ACRheum#ACRAmbassador
The vasculitis of #COVID19.
https://t.co/DLaZnmm9eq @TheLancetRheum
Unique features w/ mimics that account for multi-organ involvement, clotting, and pulmonary vascular immunothrombois. A very insightful review/perspective
Not seeing our loved ones, not being able to be together or embrace each other, is incredibly hard. I know people are frustrated. But we need your patience just a little while longer. Your 9-1-1 call is being answered.