Brian Paegel

Miniaturizer 🔬 DNA-Encoded Librarian 🧬 Drug Hunter 🔍 Prof @UCIrvine 🐜🍴 Dad/Husband 👨‍👨‍👧‍👦 he/him 🏳️‍🌈

[Brian Paegel @BrianDNA]

I am seeking a postdoctoral fellow to work on drug discovery technology development (DNA-encoded libraries, solid-phase synthesis, tissue printing, polymer chemistry, cellular assay development, and microfab/microfluidics). Send a CV and cover letter if interested!

[Brian Paegel @BrianDNA]

Methylate to degrade, @TheAlbrecht_Lab? I'm interested.

[Laurence Seabrook @LJSeabrook]

I’m so excited to welcome MrTAC to the world of targeted protein degradation! We created a chemical inducer of arginine methylation that can be used to degrade proteins in lysosomes 💊 So grateful for everyone involved in this project 🥳🥳 https://t.co/k3ltO0LKfB

[Brian Paegel @BrianDNA]

@TheAlbrecht_Lab @carointhelab @LJSeabrook Make it more degrader!

[Brian Paegel @BrianDNA]

Fab work from @TheAlbrecht_Lab showing B6 levels regulated by novel degradation of PDXK. Congrats team! 🎉

[Brian Paegel @BrianDNA]

@TheBickerLab I’m suspicious already. Do I even know you????

[Brian Paegel @BrianDNA]

@doc_jlmeier No BRD4DAYZ?

[Brian Paegel @BrianDNA]

@SpitaleLab Congrats y’all! 🔥

[Brian Paegel @BrianDNA]

@JessenLab Not enough phosphorus atoms here!

[Brian Paegel @BrianDNA]

Thanks to fabulous collaborators Christian Cunningham and Alix Chan 🧬@genentech🧬 and bead-tastic long-time scientific associate 🔵🔵🟠🔵@valcavett. This was a dream on paper not too long ago! 🎶Don't~stop~believin'~🎶 @UCI_SPPS

[Brian Paegel @BrianDNA]

What goes better with @UCIrvine than boba? Standard magnetic microbeads can template unusually uniform gel particles just by bulk emulsification. Lots of potential apps, but this paper details a super nifty one: proximity-driven biochemical synthesis!
https://t.co/zJ3517E5Xw

[Brian Paegel @BrianDNA]

I'm sure there will be many more applications. See our first app with @ChaputLab looking at xeno nucleic acids!

https://t.co/d0Vq5UpkkA

[Brian Paegel @BrianDNA]

@scarletjpark Big congrats! Where to next?

[Brian Paegel @BrianDNA]

@disney_lab @ChaputLab pulling hard for "X"

[Brian Paegel @BrianDNA]

Welcome to @UCIrvine, Trader Lab!

[Trader Lab @DJTraderLab]

We’re here for the party (and some science too) @UCI_SPPS

[Brian Paegel @BrianDNA]

@DJTraderLab @UCI_SPPS Welcome, you amazing new anteaters! Zot zot zot!

[Brian Paegel @BrianDNA]

@matoseviclab @chadtough Congratulations! 🎉

[Brian Paegel @BrianDNA]

@tfmPhD Well that doesn’t sound awesome…

[Brian Paegel @BrianDNA]

@RobertoZoncu @HijaiShin @CRI_UTSW Fabulous news! Congrats both!