Brigitte Hanly PhD

CEO Chief Scientist at Stemaid

[Brigitte Hanly PhD @BrigitteHanly]

https://t.co/vASbTAci4e

[Krister Kauppi - Rapamycin Longevity Lab @KristerKauppi]

A new lifespan study in mice was published this month regarding a combination therapy where Urolithin A, Quercetin, NR, Alpha-lipoic acid and SRN-820 were combined. It showed a 33% increase in median lifespan. They also tested Rapamycin alone and it showed a 21% increase.

While these aren't any big values they point once again toward that combination therapies are the way forward. Very few resources are currently put into researching combinations and my guess is that when we start to see really big lifespan effects then it will become much easier to forecast whether an intervention really works in humans through various metrics in much early stages.

One very interesting thing regarding the study would have been to explore each intervention individually because I believe there is potential to improve the cocktail recipe. Perhaps some compounds could be removed due to having little to no effect and others could be added.

But step by step we are moving ahead! I have also added the four data points from this study to Rapamycin Longevity Lab's (@omipallRLL) Longevity Intervention Database (LID). So now we have more than 2800 data points there!

[David Sinclair @davidasinclair]

https://t.co/SOjjai8VSH

[VraserX e/acc @VraserX]

We might have just witnessed the first real mind upload. 🤯

Scientists scanned a fruit fly brain neuron by neuron, synapse by synapse, recreated it digitally, and placed it inside a simulated body.

The fly walked. Groomed. Fed.
No training. No prompts. No learning phase.

The behavior was already in the wiring.

That’s not just neuroscience anymore.
That’s the first glimpse of digital minds.

[Brigitte Hanly PhD @BrigitteHanly]

@bryan_johnson The best are those derived from Pluripotent stem cells

[Nature is Amazing ☘️ @AMAZlNGNATURE]

Just found out that rabbits can swim. Also learned their ears go into swim mode when they do. This is important news.

[Brigitte Hanly PhD @BrigitteHanly]

@biogerontology Dr Paziotopoulos at https://t.co/Z8UWwF5ikx

[Alex Plesa @amplesa]

Can we reverse aging?
7 yrs ago, Ocampo et al. showed that partial reprogramming can ameliorate aging hallmarks. But, OSKM induction has safety limitations & no new factors have emerged since. Here, https://t.co/7ZXhqHYDAD we used 🧬 screens to find new rejuvenation factors🧵1/8

[Mark Hyman, M.D. @drmarkhyman]

For years we’ve been told that low to moderate alcohol intake could be safe and even sometimes beneficial for us in the case of red wine.

A systematic review and meta-analysis published in JAMA of over 100 studies and nearly 5 million people found otherwise.

They found no significant reductions in risk of all-cause mortality for drinkers who drank less than 25 grams of ethanol per day (2 drinks), and there was a significantly increased risk of all-cause mortality among female drinkers who drank 25 or more grams per day and among male drinkers who drank 45 or more grams per day.

We’ve also since learned that many of the pro-alcohol studies were (unsurprisingly) funded by the alcohol industry, and we’ve seen other studies showing that moderate consumption of alcohol can increase the risk for cancers of the breast, esophagus, head, and neck, and are also linked to high blood pressure and a serious heart arrhythmia called atrial fibrillation.

While this may not be the most popular study to share, it’s important to know about it. I like to use this information to make mindful choices about how much alcohol I consume in the context of a healthy and balanced lifestyle.

What benefits have you noticed from reducing your alcohol consumption?

DOI:10.1001/jamanetworkopen.2023.6185

[Brigitte Hanly PhD @BrigitteHanly]

@mkaeberlein https://t.co/kCqLgMVOrN

[Brigitte Hanly PhD @BrigitteHanly]

I think their shock is more to see us still killing each others for territories, race, skin, religion differences .. we might solve aging before solving that terrible competition disease 🧐… let’s solve aging quickly, the rest will have to align 😃

[David Sinclair @davidasinclair]

If aliens saw us speaking to people overseas on pocket devices, speeding in self-driving cars, and flying in giant planes, they’d be shocked that aging still hadn’t been solved

[Brigitte Hanly PhD @BrigitteHanly]

The perception of moral decline is an illusion...It is pervasive, perdurable, unfounded and easily produced. A fascinating study!

https://t.co/vzgilsZED6

[Brigitte Hanly PhD @BrigitteHanly]

Biggest smile of the day 😃 thanks @aubreydegrey

[Brigitte Hanly PhD @BrigitteHanly]

It would be interesting to do a metabolome test before and after 😃

[Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs) @biogerontology]

I can easily build an aging clock based on the music you listen to. And I can also teach you how to "look younger" by switching to other music.
These types of clocks can not induce significant biological changes. I call these "ACoNPU" - aging clocks of no practical utility.

[Brigitte Hanly PhD @BrigitteHanly]

@CharlesMBrenner We have been using pluripotent stem cells and pluripotent exosomes for 15 years without adverse effects. The key is to use these Yamanaka factors along with all the other factors expressed by pluripotent cells

[Brigitte Hanly PhD @BrigitteHanly]

@CharlesMBrenner We have been using pluripotent stem cells and pluripotent exosomes for 15 years without adverse effects. The key is to use these Yamanaka factors along with all the other factors expressed by pluripotent cells

[Andrew D. Huberman, Ph.D. @hubermanlab]

As we head toward the “spring forward” daylight savings, I am reminded how these rules are based on total lack of how our circadian biology actually works. I believe the solution is in educating our lawmakers.
After all most of them look like their health could use a boost too!

[Aubrey de Grey @aubreydegrey]

@AerithGarden @mkaeberlein Indeed. Longevity Hackers is coming; see the piece in Forbes about it that just came out: https://t.co/z06IwjjuCl

[Aubrey de Grey @aubreydegrey]

I urge my colleagues to join me in deprecating the media's persistent use of weasel wordings that seduce readers into dismissing us as fanciful or misguided. Stop using "death" or "old age" to mean aging. Old age is what we want to enhance, not cure. 1/2

https://t.co/nqGztvrPBC