Bobby Dua

POV from the peanut gallery

[Bobby Dua @BubbaDua]

@hvgoenka Beautiful. Lovely voice.

[Bobby Dua @BubbaDua]

@kaushikcbasu Communist tuchiye, zip your gob. You spew nonsense. You’re a blot on academia and humanity.

[Bobby Dua @BubbaDua]

@hvgoenka

[Bobby Dua @BubbaDua]

@sushantsareen Fraud Marshal has immunity. Not one word from the USDOS or western media either. Where are the likes of Greta Thunberg?

PK can’t be saved. Show mercy. Break it up.

[Aditya Raj Kaul @AdityaRajKaul]

#BREAKING: Massive violence is being reported in Pakistan Occupied Jammu & Kashmir (PoJK) after firing by Pakistani security forces on the day of sham stage managed elections. Pakistani forces must be fuming with resistance shown by people by full scale boycott of polls.

[Bobby Dua @BubbaDua]

@theangryprophet @cenamdx @paulg @Chicly0 @2abstract4me On KG Marg.

[Bobby Dua @BubbaDua]

@tathvamasi6 Beautiful.

[Bobby Dua @BubbaDua]

@amitmalviya @sreemoytalukdar Lock them up. These are not aggrieved students.

[Afshine Emrani MD FACC @afshineemrani]

I'm a cardiologist. Everyone is sharing this study as a skin story. They're burying the part that matters.
Scientists took the aorta of a 75-year-old donor, applied a single engineered enzyme, and stripped away more than 70% of the molecular damage — bringing it down to the levels you'd see in a 30-year-old artery.
Published five days ago in Nature Communications. Revel Pharmaceuticals, with Calico and the University of Colorado.
Here's what they erased.
Sugar reacts with proteins in your body the same way heat browns bread — slowly, over a lifetime. It leaves behind a residue called CML, the most abundant advanced glycation end product in aging tissue. It welds itself onto collagen and elastin in your skin, your eye lens, and your arterial walls.
Two things follow. Your arteries stiffen. And CML latches onto a receptor called RAGE, which drives chronic inflammation — the exact fire I've been writing about for months as the engine of heart disease.
Since the 1980s this damage was considered permanent. Your body has no enzyme to remove it. Every existing approach only slows new damage from forming. Nothing touched what was already there.
So they built an enzyme that doesn't exist in nature. They screened 45,000 protein structures, then ran five rounds of directed evolution across more than 500 million variants until they had CMLase — a molecular lawnmower that oxidizes the CML off the protein and restores the original, healthy lysine underneath.
Not patched. Reversed.
Over 70% cleared from elderly arterial tissue. Over 55% from elderly skin — below the levels found in 31-year-old skin. 45-78% in lens proteins. The CEO said they expected 20% and were floored.
Arterial stiffness drives systolic hypertension, heart failure, and stroke, and I have no drug that reverses it. I can slow the process. I cannot undo it. This paper says undoing it may be possible.
The caveats are real and I won't skip them. This was done on donated tissue in a dish, not in a living person. No functional data yet — we don't know if that artery got measurably more elastic. Delivering a large enzyme deep into human tissue is a hard, unsolved problem. Clinical trials are years away.
But something considered permanent for forty years just came off human tissue.
We spent a century learning to slow aging. Someone finally figured out how to erase it.
Thank you @theallinpod @friedberg @chamath @pesottas

[Bobby Dua @BubbaDua]

@afshineemrani @elonmusk Thanks. Wonderful explanation.

[Bobby Dua @BubbaDua]

@BabonesBhai Yes. Glad to see this issue settled for good.

Justin Trudeau is a vain man. He had unduly relied on khota Jagmeet Singh’s political favors instead of listening to decades-long GOI exhortations.

Khalistani khotas are happily greasing the skids for their self-destruction.

[Bobby Dua @BubbaDua]

@hvgoenka All four.

Courtesy and respect for elders, disabled, parents w/ kids, pregnant women showcase refined upbringing. Civic affection, altruism, empathy enhance social cohesion and national security.

[Bobby Dua @BubbaDua]

@aravind Not so, Aravind.

Urine and moisture is recycled into drinking water and dehydrated solid waste residue is brought back to Earth.

Practice of jettisoning urine into space has long been abandoned. Besides, discarded urine would instantly freeze and sublimate into gas in vacuum.

[Bobby Dua @BubbaDua]

@PawanDurani Aap ko bhi, bhai sahib. 🙏🏼

[Bobby Dua @BubbaDua]

@Lumber9r @Chellaney Hindus meditate and become resolute through intentionality.

Wax melts when heated.

Know the difference, inbred Pakistani.

[Massimo @Rainmaker1973]

Voyager hit a 90,000°F wall at the solar system’s edge.

NASA’s Voyager 1 spacecraft crossed one of the most dramatic frontiers in the cosmos: the heliopause, the tenuous boundary where the Sun’s influence finally gives way to interstellar space. What the probe discovered there was astonishing—a turbulent zone of superheated plasma with temperatures soaring between 30,000 and 90,000 °F (roughly 17,000–50,000 °C).

This wasn’t a physical wall or barrier, but a dynamic transition region where the outward-flowing solar wind abruptly slows, compresses, and piles up against the incoming pressure of interstellar material. That compression converts kinetic energy into thermal energy, driving the plasma to extreme heat levels far beyond anything found inside the heliosphere.

Remarkably, despite the blistering temperatures, this “wall of fire” would pose no danger to a hypothetical astronaut. The plasma is extraordinarily diffuse—far less dense than the best vacuums achievable in Earth laboratories—so there are simply too few particles to transfer meaningful heat. The region is hot in temperature but cold in practical effect.

Voyager’s instruments captured clear signatures of the crossing: a sudden plunge in solar wind particles, a sharp rise in galactic cosmic rays, and faint plasma oscillations that revealed the density and temperature of this exotic boundary layer for the first time. These vibrations—analogous to ripples on an unseen sea—provided direct measurements of conditions in a realm previously known only through theory.

The heliopause itself serves as a vital shield. The entire heliosphere—the vast bubble carved by the Sun—deflects most of the galaxy’s high-energy cosmic radiation, helping protect life on Earth from constant bombardment. Beyond this protective envelope lies the harsher, unfiltered radiation environment of the interstellar medium.

Today, more than 15 billion miles (24 billion kilometers) from home, Voyager 1 remains the farthest human-made object ever sent into space. Still operational and transmitting precious data, it continues to reveal the secrets of this distant frontier.

At the outer limit of our solar system, space is neither empty nor serene. It is a violent, glowing threshold—and humanity has only begun to map its mysteries.

[Bobby Dua @BubbaDua]

@Jetty_Fdr @Schandillia You’ve just described karma.

Actions have consequences. Karma is habit forming; it urges one to think, listen, dialog more than to act, talk, argue impulsively.

One doesn’t have to imbue karma with divine providence.

Sanatan Dharma is rooted in pragmatism, not rituals alone.

[Curiosity @CuriosityonX]

BREAKING🚨: ALL FIVE types of nucleic acid bases, the building blocks of LIFE 'DNA and RNA', have been found in samples collected from asteroid Ryugu

[AMI Labs @amilabs]

Advanced Machine Intelligence (AMI) is building a new breed of AI systems that understand the world, have persistent memory, can reason and plan, and are controllable and safe.

We’ve raised a $1.03B (~€890M) round from global investors who believe in our vision of universally intelligent systems centered on world models. This round is co-led by Cathay Innovation, Greycroft, Hiro Capital, HV Capital, and Bezos Expeditions, along with other investors and angels across the world.

We are a growing team of researchers and builders, operating in Paris, New York, Montreal and Singapore from day one.

Read more: https://t.co/kyVAL7EoFx
AMI - Real world. Real intelligence.

[Josh Kale @JoshKale]

Scientists just copied a Fruit Fly's biological brain and trapped it inside of a computer.
Not an AI model trained to act like a fly... A total digital copy of a fly !! This is some sick sci-fi stuff:

- They scanned and copied the brain, neuron by neuron, synapse by synapse, from electron microscopy data.
- Then dropped that brain into a simulated body in a video game like environment.

The fly walked. It groomed. It fed. Nobody taught it anything. The behavior was already in the wiring.

The entire premise of modern AI is that intelligence is something you train into a system. This is proof it's something you can transfer out of one. Wild times