Excited to share our new paper in Nature! We discovered the first small-molecule inhibitors of β-arrestins, uncovering a new way to selectively modulate GPCR signaling. https://t.co/10PIWLvDTp @AlemKahsai1@robertjlefkowi1
Excited to share our paper in @Nature on small-molecule modulation of β-arrestins, key GPCR signaling proteins, revealing a druggable site and a new strategy for selectively targeting GPCR signaling. @robertjlefkowi1 , @NPakharuk
https://t.co/AC4tXD7sM4
https://t.co/RxD3XIfvHI
Check out our work on how beta-arrestin activates proto-oncogene kinase Src! This is the first structure of beta-arrestin in complex with the effector enzyme https://t.co/rbEQW1fabS
Excited to share our new preprint where we use math and crainbow lineage tracing to identify an occult transition early in the life of a tumor. Well done @josh_ginzel And team! @DukeSurgery@DukeDscb
Happy to share our work on the role of leucine sensing by the Sestrin-mTORC1 pathway in vivo, out now in @ScienceMagazine. Extremely grateful to everyone who contributed over the years to make this possible.
https://t.co/fnjJecvW68
As many others have noted with their remembrances of Marc Caron, he was an outstanding scientist and mentor. It was great training in the lab adjacent to his, as I could learn about different approaches to addressing questions in receptor biology. 1/2
Marc will be sorely missed by the Duke Receptor Biology community for his outstanding science and warm persona. And I will miss seeing as many crazy mouse behavior experiments in data club. "Social defeat" - what the heck is that? 2/2
Our dearest mentor Marc is no longer with us. A big loss for the scientific community and for all his trainees. Was supposed to meet him on zoom today but was not meant to be and now I regret that I didnt get to talk to him one last time. May his soul rest in peace.
Want to make images like this https://t.co/UTFIrA1xIj to discover new treatments for breast cancer? Post doc positions in my lab are open, Apply here! https://t.co/ehNxOoVjVX
Our paper describing a new G protein coupled receptor signaling pathway is now out at @ScienceMagazine, thanks to a great research team including co-first author @TomPack001, and @SudarRajagopal. #GPCR.
https://t.co/CCn2EGfamz
We just posted our most recent work on a new paradigm for G protein-coupled receptor (GPCR) signaling on bioRxiv. This work was led by @kevinzzheng, an outstanding tech (applying soon for MSTP), along with Anmol Warman, another outstanding undergrad. 1/6 https://t.co/4iq0GqkySU
Nonfiction Book Review: A Funny Thing Happened on the Way to Stockholm: The Adrenaline-Fueled Adventures of an Accidental Scientist by Robert J. Lefkowitz, with Randy Hall. Pegasus, $27.95 (336p) ISBN 978-1-64313-638-7 https://t.co/Fjf9dCCRzT via @publisherswkly