CRI Mouse Genome Engineering Core at UTSW

Mouse Genome Engineering Core @CRI_UTSW. We produce mouse models to support fundamental & translational research for scientists @UTSWNews & beyond.

[Hao Zhu Lab @Zhu_Lab]

We are looking for a scientist to lead the CRI transgenic core. This is an opportunity to run a core AND to create a cutting-edge research program on in vivo gene editing. We've made > 200 new GEMMs since 2018, now we want to innovate! Please retweet https://t.co/4jIAkBWQXp

[Rodrigo Romero Rangel @RRomero_PhD]

Next generation of mouse models has arrived. Congrats to all authors! @LabJacks @davidrliu

https://t.co/inkF3XX8p1

[David R. Liu @davidrliu]

Today we report in @NatureBiotech the development of dual-AAV in vivo delivery systems for prime editors that can support efficient prime editing in multiple organs such as brain, liver, and heart.
1/4

[Nature Biomedical Engineering @natBME]

Ex vivo prime editing of patient haematopoietic stem cells rescues sickle-cell disease phenotypes after engraftment in mice

https://t.co/euF36D4e2N

[Hao Zhu Lab @Zhu_Lab]

Somatic mutations accumulate in “normal” non-cancerous tissues (blood, skin, liver). But why are mutant clones selected? Do they merely proliferate more, selfishly? Or can clones adapt to disease? Could they protect tissues? We shed light on this: https://t.co/Vu1d4U3stc 1/10

[David R. Liu @davidrliu]

Today we report in @ScienceMagazine a one-time base editing treatment for Spinal Muscular Atrophy (SMA), the leading genetic cause of infant mortality worldwide, affecting ~1 in 10,000 births. https://t.co/oLp8VN0Iiw
PDF: https://t.co/JoKm9BxW89
1/17

[Eric Topol @EricTopol]

Brings to mind the exciting potential of #CRISPR genome editing (here RNA base editing) to correct hearing loss in the future
https://t.co/rbQeCV3m4I @ScienceTM

[CRI Mouse Genome Engineering Core at UTSW @CRI_TgCore]

Glad to help @SunLab19 in generation of new transgenic lines

[Lu Sun @SunLab19]

With the amazing support from @CRI_TgCore Our postdoc fellows @ZhangTingxin @AksheevB work fearlessly in generating novel genetic reagents and discovering new mechanisms governing axon-oligodendrocyte communications

[Lu Sun @SunLab19]

With the amazing support from @CRI_TgCore Our postdoc fellows @ZhangTingxin @AksheevB work fearlessly in generating novel genetic reagents and discovering new mechanisms governing axon-oligodendrocyte communications

[Feng Zhang @zhangf]

CRISPR technologies are powerful gene editing tools because they are programmable. We are excited to describe 3 new programmable systems, IscB, IsrB, and TnpB, some of the most abundant genes on the planet, with potential for gene editing. @ScienceMagazine https://t.co/dY8FXBYIM8

[David R. Liu @davidrliu]

Today we report in @Nature a base editing strategy that efficiently corrects the mutation in the β-globin gene HBB that causes sickle cell disease (SCD), the most common deadly genetic disorder, rescuing the disease in mice. https://t.co/Gj8VOAFrc1
https://t.co/gzO3WwNuKT
1/11

[CRI Mouse Genome Engineering Core at UTSW @CRI_TgCore]

Pleasure to see that the lineage tracing lines generated by our core contributed to this beautiful work, discovering that the cells in zone 2 repopulate the liver" @YonglongW @Zhu_Lab

[Hao Zhu Lab @Zhu_Lab]

Excited to share our latest work on liver growth + regeneration. Diverse hepatocytes carry out distinct functions, but it is still unclear which ones are the source of new hepatocytes. Yonglong Wei discovered that cells in zone 2 repopulate the liver.
https://t.co/wNHCwxZbaY

[CRI Mouse Genome Engineering Core at UTSW @CRI_TgCore]

It is a great feeling to generate new mouse models to answer biomedical questions for researchers both @UTSWnews and from outside institutions.

[Hao Zhu Lab @Zhu_Lab]

So satisfying to obtain three floxed mice in one day for a single client. Our own @CRI_TgCore is truly a GEMM... Also thank you @CRISPRGuru for all your help.

[David R. Liu @davidrliu]

Today we report in @NatureProtocols detailed procedures for how to design and execute base editing experiments in mammalian cells, with many design steps also applicable to other cell types. Congrats Greg Newby and Tony Huang!
https://t.co/y5jfL2nukK

https://t.co/ruGwzrN5XX

[Joshua Modell @jwmodell]

Just when you thought you knew everything about Cas9... Pleased to share our lab’s first paper, now online @CellCellPress: https://t.co/qcIBSh1ZnH. We found Cas9 transcriptionally regulates its own promoter using a natural single-guide RNA. Kudos @reworkman0, @tejapammi et al.

[Children’s Research Institute at UT Southwestern @CRI_UTSW]

We are excited to welcome Natasha Corbitt, M.D., Ph.D., to CRI! Dr. Corbitt is the first Black female pediatric surgeon in the U.S. to also hold a Ph.D. Learn more about her work @UTSWNews & @Zhu_Lab studying hepatobiliary diseases in children. #LifeAtCRI

https://t.co/cmvad1qYe7

[The Kohn Lab UCLA @Kohn_Lab]

Join us tomorrow at Synthego’s #WorldCRISPRDay event. You will hear from experts like our mentor, Dr. Kohn, talk about #CRISPR ‘s role on cell and gene therapies. This is just one of many sessions that includes an ALL-STAR lineup of experts and pioneers. Registration is FREE.

[Children’s Research Institute at UT Southwestern @CRI_UTSW]

Congratulations to Dr. Ralph DeBerardinis (@RJDLab), professor at CRI, on his election to the National Academy of Medicine (@theNAMedicine) for his outstanding contributions to cancer metabolism! #NAMmtg

Learn more about this award and his research ⤵️
https://t.co/WJkYoCruXp

[nature @Nature]

It’s #CRISPR. Emmanuelle Charpentier and Jennifer Doudna ,who pioneered the revolutionary gene-editing technology, are the winners of this year’s #NobelPrize in Chemistry. #NobelPrize2020
https://t.co/I9uqEE41or

[The Nobel Prize @NobelPrize]

Congratulations to our newest #NobelPrize laureate Jennifer Doudna.

From this picture we can imagine that she was happy to find out she had been awarded this year’s Chemistry Prize!