Jing

Mouse manipulator, Human physiology fan, Cell biology lover, Fascinated by biochemistry in Vivo

[Jing @CaATiER_Chop_ER]

I will briefly summarize what we reported in the article- just to entice but not as a spoiler.
1. We set out to reduce ER stress in pancreatic beta cells, as we suspected that beta cells are stressed by insulin synthesis burden in T2Ds (proinsulin to be exact).
1/x

[SpaceX @SpaceX]

Watch Starship's tenth flight test → https://t.co/UIwbeGoo2B https://t.co/BFrpQPQFUw

[Herman Pontzer @HermanPontzer]

What are the relative impact of diet vs physical activity on the global obesity crisis? New paper out @pnas uses the DLW Database with 4000+ participants across 34 populations to investigate Obesity & Energy Expenditure Across the Economic Spectrum. Open access link below!🧵1/

[Jing @CaATiER_Chop_ER]

@JimJohnsonSci
@DanielJDrucker
Another therapeutic application unlocked for targeting Chop in beta cells?

[Jing @CaATiER_Chop_ER]

https://t.co/rZ4TvZsSij

"...targeting CHOP in beta-cells is a promising lead for HFpEF pathogenesis therapy."

[nature @Nature]

Nature research paper: Stepwise ATP translocation into the endoplasmic reticulum by human SLC35B1

https://t.co/wfLnLdbdQb

[Daniel J Drucker @DanielJDrucker]

Adipose tissue and viral infection-a better understanding of the interactions between immune cells and adipose tissue in response to inflammation. @naturemetabolism

https://t.co/zzlaZRLr8V

[Ani Deshpande @anideshpandelab]

Watch full episode here https://t.co/FuBYyYuYmA

[Julio Ayala @TheBurro34]

Please join us in Nashville on June 13th as we honor the life and contributions of Dr. David Wasserman. Registration for this event is open until May 2. Please follow the redcap link below to register.

[Daniel J Drucker @DanielJDrucker]

Interrogation of how the mTOR pathway senses and is activated by availability of linoleic acid, leading to increased #breastcancer cell proliferation in a subtype-specific manner @ScienceMagazine
https://t.co/1NDq5zP43j

[Jing @CaATiER_Chop_ER]

Adrenomedullin triggers insulin resistance https://t.co/wNxKC1L8zV

[Jing @CaATiER_Chop_ER]

That's equivalent saying "hyperinsulinenia causes insulin resistance"😂😂

[Nature Reviews Endocrinology @NatureRevEndo]

New content online: Obesity induces systemic insulin resistance via endothelium-specific insulin receptor inhibition https://t.co/pAK3HyZqzt

[Nature Reviews Endocrinology @NatureRevEndo]

New content online: Obesity induces systemic insulin resistance via endothelium-specific insulin receptor inhibition https://t.co/pAK3HyZqzt

[Eric Topol @EricTopol]

In a small study of healthy men, brief intake of high calorie sweet and fatty foods disrupted brain insulin action and led to liver fat accumulation for a prolonged period
https://t.co/aeUggkneov

[Tony Hui @realTonyHui]

Happy to share the final version of this work where we incorporated isotope labeled CO2 data into mass spec-based flux analysis framework to build a whole-body flux model of energy metabolism. Full article access here: https://t.co/aJJF3MqqNs
@yuanbogeneral

[Jing @CaATiER_Chop_ER]

@JimJohnsonSci @DanielJDrucker

[Jing @CaATiER_Chop_ER]

"...consumption of 0.15% aspartame (APM) markedly increased insulin secretion in mice and monkeys. Bilateral subdiaphragmatic vagotomy obliterated APM-elevated blood insulin levels, demonstrating crucial roles of parasympathetic activation in regulation of insulin secretion"

[Cell Metabolism @Cell_Metabolism]

New! Online now: Sweetener aspartame aggravates atherosclerosis through insulin-triggered inflammation https://t.co/m1pqIUjlFt

[Jim Johnson, PhD @JimJohnsonSci]

Interesting paper and consistent with Jon Little’s paper in Nature Communications https://t.co/MRTcSAGxww

[Providence Business First @BF_Providence]

Attorney General Andrea Campbell and 21 counterparts across the country sued the National Institutes of Health on Monday after the NIH said it would stop funding indirect costs for research. https://t.co/qYA93dMBuy

[Jing @CaATiER_Chop_ER]

@JeffreyRMillman As expected and we deal with this all the time during our research -
Get the noise out of the true signal...and you get good science.
https://t.co/RexhbZfNXw

[Saltiel lab @LabSaltiel]

this is beyond insane. I assume it will be challenged in the courts immediately. Anyone who has run a research operation knows that this would spell the end of the enterprise as we know it. Who is going to pay for the energy, heat, air conditioning, OSHA, other facilities costs?