Shalini K Reddy

Lead CRISPR Center @ GOSH UCL; Genome Engineer @ Sanger Institute; Post Doctor in Infectious Diseases Kings college-Guys hospital

[Shalini K Reddy @Capt_Shalini]

From vision to impact, I am proud to see our GOSH UCL CRISPR Centre shared on DNA Day!
The GOSH UCL CRISPR Centre
https://t.co/2SqKTQ1WN6

[Eric Topol @EricTopol]

Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism"
—the 1st human to undergo custom genome editing
—outgrowth of decades of NIH funded research
https://t.co/HmJxYWDCV7
https://t.co/4DsNELnBut @NEJM
https://t.co/y7NMGPpXnE

[Shalini K Reddy @Capt_Shalini]

@RishiSunak When dharma calls, every Indian is a warrior, born to protect, bound to rise.

[Shalini K Reddy @Capt_Shalini]

@DrSJaishankar We choose peace, but if challenged, we respond with power and precision.

[Shalini K Reddy @Capt_Shalini]

@bigtvtelugu Don’t worry. He’s still crying over the breakup with India 🤣🤣🤣

[Shalini K Reddy @Capt_Shalini]

@bigtvtelugu Oh, we belong to England, now we own half of London! Karma 😂😂😂😂😂😂

[Shalini K Reddy @Capt_Shalini]

@KarthikIndrAnna India has 1.4 billion people. If a few leave and succeed abroad, India won’t sink. Let’s focus on building a nation they’ll want to return to.

[CRISP_SCIENCE @ScienceCrisp]

"Highly efficient #CRISPR/Cas9-mediated exon skipping for recessive dystrophic epidermolysis bullosa"
du Rand A [..] Sheppard H.
Bioeng Transl Med. 2024-01-17.
https://t.co/UMWCqwMRm0
… detected large on-target structural variants (deletions up to >5 kb at a frequency of ~10%)

[Shalini K Reddy @Capt_Shalini]

For those who believe that using base editors and prime editors is safe, it's essential to note that they employ nickases, causing a single-strand break and damage. Therefore, conducting thorough genotyping is imperative to select clones that are genetically suitable.

[CRISP_SCIENCE @ScienceCrisp]

"Detailed mechanisms for unintended large DNA deletions with #CRISPR, base editors, and prime editors"
Hwang GH, Lee SH [..] Bae S
bioRxiv 2024-01-05 (preprint)
https://t.co/T3k7dDydz3
CRISPRi screen with Nanopore seq. >
TMEJ is the dominant pathway generating large deletions.

[CRISP_SCIENCE @ScienceCrisp]

"Detailed mechanisms for unintended large DNA deletions with #CRISPR, base editors, and prime editors"
Hwang GH, Lee SH [..] Bae S
bioRxiv 2024-01-05 (preprint)
https://t.co/T3k7dDydz3
CRISPRi screen with Nanopore seq. >
TMEJ is the dominant pathway generating large deletions.

[CRISP_SCIENCE @ScienceCrisp]

"Effective prevention of atherosclerosis by non-viral delivery of #CRISPR/Cas9"
Xu C, Zhang X [..] Du J, Li Y, Xu F-J.
Nano Today. 2023-12-12.
https://t.co/6vFDOuNHSF
PuPGEA/pCas9-Pcsk9 composed of low-toxic and liver-targeting polycation

[Amy R Eggers @AmyReginaEggers]

Today I am excited to share our preprint “Rapid DNA unwinding accelerates genome editing by engineered CRISPR-Cas9” from @doudna_lab, with co-authors @kaichen_1990, Kasia Soczek, @owen_t_tuck, @Ee_Doherty, @BW_Thornton, Bryant Xu, and Marena Trinidad. https://t.co/iIdHq255py
1/7

[CRISP_SCIENCE @ScienceCrisp]

News & Views "Interpretable model of CRISPR–Cas9 enzymatic reactions"
Wen DJ, Theodoris CV. Nat Comput Sci 2023-12-14.
https://t.co/sLjBQ48bUs
Elektrum combines neural architecture search, kinetic models and transfer learning to effectively discover CRISPR–Cas9 cleavage kinetics.

[CRISP_SCIENCE @ScienceCrisp]

"Efficient gene editing in induced pluripotent stem cells enabled by an inducible adenine base editor with tunable expression"
Nandy K [..] Velayudhan SR. Sci Rep. 2023-12-11.
https://t.co/FtHtsxTOet
#CRISPR; AAVS1-iABE8e

[CRISP_SCIENCE @ScienceCrisp]

“#CRISPR-Analytics (CRISPR-A): A platform for precise analytics and simulations for gene editing"
Sanvicente-García M [..] Güell M.
PLoS Comput Biol. 2023-05-30.
https://t.co/ocsQdfxCQs

CRISPR-A emerges as an evolution of CRISPR-GA, the first NGS-based method for ...

[Shalini K Reddy @Capt_Shalini]

I'm revisiting Sapiens after 9 years, you’ll find that the book still holds up. The author beautifully narrates who we are, how we got here, and where we might be headed...

Sapiens: THE MULTI-MILLION COPY BESTSELLER https://t.co/xreRPsT6Bn

[Rolen Quadros @rolen_m]

Latest preprint @biorxivpreprint from our lab @CRISPRGuru and @Masato_Ohtsuka Delivering mRNAs to mouse tissue using SEND system #CRISPR #SEND #GENEEDITING https://t.co/nLtgHOuYj0

[george church @geochurch]

2013 resistance to many viruses.
2022 resistance to all natural viruses.
The method should work for any host.
https://t.co/TVo6tAsJeu

[CRISPRpapers @CRISPR_papers]

Precise CRISPR-Cas-mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells https://t.co/aHGRuysmW0

[Shalini K Reddy @Capt_Shalini]

Our Genome Editing work!! @Sangerinstitute