#TECPR1 replaces #ATG16 as receptor of the ATG5/ATG12 E3 ligase to conjugate #LC3 to damaged vesicles displaying sphingomyelin on their cytosolic face. New LC3 ligase for #autophagy and first ever receptor for sphingomyelin! Discovered by K.Boyle...
https://t.co/pJKCT2rWQB
So excited to share latest work from @Elliott_Lab_Ox! We find BIRC6, an enormous #ubiquitin IAP ligase, directly inhibits caspases and we show how this is blocked by SMAC. https://t.co/xSGWSKk1uh Plus great mass spec collab with @adanpinto@kesslerlabox
Delighted to share this research in @CurrentBiology! My thanks to @FelixRandow, @KukulskiWanda, Keith Boyle and Sean Munro @CellBiol_MRCLMB.
Transbilayer Movement of Sphingomyelin Precedes Catastrophic Breakage of Enterobacteria-Containing Vacuoles https://t.co/stSCFHcXmg