Carl Orr

[Carl Orr @CarlorrCarl]

@TomVsArthritis The sport if Kings Tom!

[Carl Orr @CarlorrCarl]

@WinEd2011 Interesting and clinically relevant question. The group were heterogenous, with variable disease duration. They were not analyzed for differences in metabolic pathways according to dis duration, though all were biologic naive so arguably a more ‘natural history’ phenotype

[Carl Orr @CarlorrCarl]

Difficult to say whether the effects are specific to tofacitinib, but it’s definitely clear that JAK STAT plays a key role in mitochondrial function/regulation #EULARJC

[Carl Orr @CarlorrCarl]

@EULAR_JC Hi all Carl Orr here, from Dublin

[Carl Orr @CarlorrCarl]

@RichardPAConway Good man Richard! It very nearly was me! Frankly, I think at this stage I should just start living out if a bag!

[Carl Orr @CarlorrCarl]

Why are doctors leaving Ireland? With less than 6 days to go before starting there, Connolly Hospital still have not furnished a roster to their incumbent doctors! Not a way to treat professionals. I wonder who is on call Monday?

[Carl Orr @CarlorrCarl]

Frank McNally: Goodbye to all that – a fond farewell to the primary school run https://t.co/M9ZZuTrFKe Beautiful article @FrankmcnallyIT

[Carl Orr @CarlorrCarl]

So frustrating- disgraceful. Love to see admin personnel being told to press hold on life and family plans... https://t.co/thUEdJEWYa

[suzid @drsuzdonnelly]

Ludicrous. In what world is next week's rota for acute medicine on call not yet available to those who will have to deliver it @PeopleofHSE @HSEvalues @HSE_HR Deeply disrespectful to doctors who are the backbone of our hospitals. https://t.co/WGNTicNMDk

[john creedon @johncreedon]

Conserve water and chill to a cool soundtrack instead.
Weeknights 8-10pm @RTERadio1

[Carl Orr @CarlorrCarl]

@johncreedon once again great show John- great mix this evening!

[Carl Orr @CarlorrCarl]

l Better! #eularjc

[Carl Orr @CarlorrCarl]

d... but we are still a while away from being able to tell our patients that it makes selection of appropriate tx for the individua #eularjc

[Carl Orr @CarlorrCarl]

I think synovial bx will become accepted routine practice, as in my experience with arthroscopy it is extraordinarily well tolerate #eularjc

[Carl Orr @CarlorrCarl]

Most welcome, and once again, many thanks for your interest in our paper! #eularjc

[Carl Orr @CarlorrCarl]

I do apologise...as I will be travelling to EWRR, leaving home at 03:30am, I will have to bow out in 5 mins! #eularjc

[Carl Orr @CarlorrCarl]

1% of healthy controls express ACPA. But combining family hx, even then poor performance at predicting those who will develop RA #eularjc

[Carl Orr @CarlorrCarl]

No doubt a second hit- and interrogating nature of this v important in understanding pathobiology of RA #eularjc

[Carl Orr @CarlorrCarl]

increase sensitivity of ACPA in predicting those who will go on to develop RA- but performance still poor! #eularjc

[Carl Orr @CarlorrCarl]

1% prevalence of ACPA positivity in healthy population. A small proportion of these develop RA. A 1st degree relative with RA #eularjc

[Carl Orr @CarlorrCarl]

That's right- these are the so-called 'at risk of RA'... #eularjc