Caydasi Lab - Cell Cycle & Genome Stability

Cell Cycle & Genome Stability Lab @kocuniversity

[Caydasi Lab - Cell Cycle & Genome Stability @CaydasiLab]

Wonderful visit from Gabriel Neurohr from @ETH to our department this week! Great science and inspiring discussions with faculty and students! Thanks @GabrielNeurohr, for the fantastic @EMBO_YIP Lecture at @kocuniversity @KocSciences. Thanks to @EMBO_YIP for making this possible!

[Caydasi Lab - Cell Cycle & Genome Stability @CaydasiLab]

Gautam Dey (@Dey_Gautam, @embl) delivered a fantastic @EMBO_YIP Lecture today as part of the MBGE Seminar Series at @KocSciences @kocuniversity.
Thank you for the energy, enthusiasm, and inspiration you shared with us and our students!

[Caydasi Lab - Cell Cycle & Genome Stability @CaydasiLab]

@syncellbiolab @embojournal @Jayantikri23 Congrats to the team!

[Journal of Cell Biology @JCellBiol]

Cargo adaptors use a handhold mechanism to engage with #myosin V for #organelle transport, say Hye Jee Hahn, Natalya Pashkova, Michael Cianfrocco, & Lois Weisman @umlifesciences
https://t.co/QiNyRnyuNf

#Microbiology #Organelles #Trafficking

[Franz Meitinger @Meitinger]

Excited to share our new preprint on @biorxivpreprint!
We show that USP28 mutations found in cancer block its interaction with 53BP1, disrupting p53 stabilization. Check out the full story...
https://t.co/t7XbfY3cID

[Saravanan Palani @syncellbiolab]

Preprint: IntAct-U-ExM enables robust, isoform-specific expansion microscopy of actin networks in yeast and mammalian cells. A cool study led by @anubhav_dhar in collab with @Sudiya14 @deepak_iisc #actin https://t.co/GTTRUF8dGC

[Caydasi Lab - Cell Cycle & Genome Stability @CaydasiLab]

@isil_aksan Sabırlar diliyorum Işıl hocam… 😔

[Caydasi Lab - Cell Cycle & Genome Stability @CaydasiLab]

@ozlemyedier @wellcometrust @kocuniversity @tugbabagcionder @Tamer_Onder @berilesin_ @merdemercann @Tbo_Lab Tebrikler!

[Eda Yildirim @YildirimLabDuke]

Department of Molecular Biology and Genetics at the Koç University College of Sciences is hiring tenure-track faculty!

[Caydasi Lab - Cell Cycle & Genome Stability @CaydasiLab]

Grateful to Patricia M. Kane and @JCellBiol for highlighting our work.

[Journal of Cell Biology @JCellBiol]

Spotlight: Kane @UpstateNews discusses new work from @MaryHuda97 et al. @CaydasiLab (https://t.co/csg8P8EyKM) showing that in S. cerevisiae transient cell cycle–dependent asymmetry in PI(3,5)P2 levels promotes vacuolar acidification in daughter cells. https://t.co/p02iARESoj

[Journal of Cell Biology @JCellBiol]

Spotlight: Kane @UpstateNews discusses new work from @MaryHuda97 et al. @CaydasiLab (https://t.co/csg8P8EyKM) showing that in S. cerevisiae transient cell cycle–dependent asymmetry in PI(3,5)P2 levels promotes vacuolar acidification in daughter cells. https://t.co/p02iARESoj

[FEBS @FEBSnews]

🚨 Attention PhD students & postdocs! Last chance to apply for the FEBS Young Scientists’ Forum in Sapanca, Türkiye (2–5 July 2025). Present your research, network with peers, and learn from top scientists.
🗓 Apply by Dec 12, 23:59 (UTC+01:00). https://t.co/R18rbMgBq7
#youngFEBS

[Caydasi Lab - Cell Cycle & Genome Stability @CaydasiLab]

@Sciezgin @EMBO @EMBO_YIP Congrats Erinç! Well deserved!

[Wallace Marshall @WallaceUcsf]

How do organelles fit together inside a crowded cell? Answering this question requires a way to image many organelles in a whole cell at high resolution with high throughput. Our new preprint shows how to do this in yeast using soft x-ray tomography

https://t.co/PbRajXb9sj

[Journal of Cell Biology @JCellBiol]

@MaryHuda97 et al. @CaydasiLab @kocuniversity show that asymmetric PI(3,5)P2 synthesis is crucial for vacuolar-pH asymmetry and provide insights into how the mother cell ages while the daughter cell is rejuvenated in budding yeast https://t.co/WhJNLm45UP

#Mitosis #CellSignaling

[Caydasi Lab - Cell Cycle & Genome Stability @CaydasiLab]

Job Alert! Our department, Department of Molecular Biology and Genetics at Koç University in Istanbul, has an open faculty position! Apply at https://t.co/Ki3jXkjHBh
@kocuniversity @KocSciences

[Eda Yildirim @YildirimLabDuke]

🚨Job Alert 🚨 @KocSciences Department of Molecular Biology and Genetics is hiring tenure track faculty. The call is broad and many different fields of biology will be considered. Join an incredible Department with great colleagues here in beautiful Istanbul!

[Caydasi Lab - Cell Cycle & Genome Stability @CaydasiLab]

We further showed that the asymmetry of PI(3,5)P2 and the PI(3,5)P2 effector Atg18 determine the asymmetry of vacuolar pH. Given the link between vacuole acidity and longevity, our results suggest that PI(3,5)P2 is key for daughter cell rejuvenation and mother cell aging.

[Caydasi Lab - Cell Cycle & Genome Stability @CaydasiLab]

I am excited to announce that our latest work is now published @JCellBiol! Huge congratulations to the co-authors @MaryHuda97 @KoyuncuMukadder @cansudilege. Big thanks to our funding bodies @Tubitak and @EMBO_YIP, @KocSciences, and to many labs who shared plasmid/strains with us.

[Journal of Cell Biology @JCellBiol]

@MaryHuda97 et al. @CaydasiLab @Kocuniversity reveal the dynamics of the vacuolar signaling lipid PI(3,5)P2 in budding yeast. PI(3,5)P2 synthesis is asymmetric during #mitosis and plays a key role in establishing vacuolar pH asymmetry. https://t.co/jDxyFim1j6

#Lipids

[Caydasi Lab - Cell Cycle & Genome Stability @CaydasiLab]

Employing a ratiometric in vivo vacuolar-pH sensor, we observed a pH drop in the daughter vacuole, while a pH increase in the mother vacuole, concomitant with changes in PI(3,5)P2 distribution during mitosis.