Very happy to see our paper
“Cancer-associated USP28 missense mutations disrupt 53BP1 interaction and p53 stabilization”
featured in the @NatureComms Editors’ Highlights (Cancer).
Many thanks to the editors for highlighting our work.
https://t.co/naUqEO6V4g
Our study on the mitotic stopwatch is out. We demonstrate that USP28 interacts with 53BP1 to stabilize p53 and show that cancer cells frequently harbor mutations that impair stopwatch assembly, thereby suppressing the mitotic stress response.
https://t.co/p4O1z8dea8
We’re recruiting a Postdoctoral Researcher at @OISTedu (Okinawa, Japan) to explore how mitotic stress shapes aging.
If you’re excited about cell biology, aging, and mechanistic discovery, we’d love to hear from you.
More info: https://t.co/lEdRcYbnGA
Join us for the Cell Division Meeting in the Pacific Island setting of Okinawa.
Hosted at OIST, this symposium brings together leading researchers to explore emerging roles of the cell cycle in development, cancer, and aging.
Registration now open: https://t.co/ATGg9TYEjN
Excited to share our new preprint on @biorxivpreprint!
We show that USP28 mutations found in cancer block its interaction with 53BP1, disrupting p53 stabilization. Check out the full story...
https://t.co/t7XbfY3cID
Check out our review on "PLK4: Master Regulator of Centriole Duplication and Its Therapeutic Potential".
Everything you need to know about centriole duplication, mitotic stopwatch and TRIM37-mediated cancer-specific vulnerabilities. @Midori_RuruOta
https://t.co/tm0BWhauuj
For all cell biologists: join the conference organized to celebrate 50 years of German Society for Cell Biology!
https://t.co/FMSFjoRNxq
Registration is open! See you in Heidelberg.
#DGZ50
A prolonged mitosis is characteristic of defects that drive genome instability. What are the underlying causes and broader implications of prolonged mitosis? Check out our review...
https://t.co/yFjjnyUKhG
Interested in Base Editing and Genetic Screening?
Check out our method chapter:
https://t.co/zeCQIETlSV
Esther Ng did an excellent job developing these methods in our lab. The constructs will soon be available on @Addgene
Many thanks to @OISTedu for supporting open access!
We are happy to share our review on the 53BP1-mediated activation of the tumor suppressor p53. We summarize the cell cycle-depend functions of 53BP1 during mitosis and interphase and address its role in maintaining a healthy tissue.
https://t.co/sA1ZkYjGAP