Chan Wing Fuk

Postdoc @ACBDresearch @MonashUni | Haematopoiesis | Molecular immunology | 3D genome | Gene regulation | CRISPR | Former @WEHI_research

[Chan Wing Fuk @ChanWingFuk]

Still feeling it isn't real ... But thrilled that I got another @NatureComms paper with @rhyscienceallan ! A more robust CRISPR activation system TETact in activating transcription from CpG-methylated loci.
https://t.co/rJUA2TlzuK

[Rhys Allan @rhyscienceallan]

💥💥Excited that our TETact study has now been published in @NatureComms https://t.co/XAbinxWfEp @ChanWingFuk did a huge amount of new work in response to reviewers comments (e.g. multiple cell types, multiple genes activated in the same cell)

[Molecular Cell @MolecularCell]

Transcription-coupled AID deamination damage depends on ELOF1-associated RNA polymerase II https://t.co/qITDz04xYX

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

[Jacob Corn @jcornlab]

Having a hard time with #CRISPR HDR? Your cells might be fighting against you! TREX1 nuclease, high in some cells, eats up HDR donor templates. Check out our paper in @NatureBiotech for the story & ways to improve HDR. https://t.co/03GokR65LA With @karasuerman1 & @J_Maciejowski

[Ben Kleinstiver @BKleinstiver]

I'm a little late to the party, but glad to share that our manuscript describing click editing has been published in @NatureBiotech. An amazing team effort led by @FerreiraSilvaJ @connorjtou & others. @CGM_MGH @MGH_RI @harvardmed #clickediting 🧬

https://t.co/EA4XGvpffy

[David R. Liu @davidrliu]

Today we report in @natBME the eePASSIGE system, which uses evolved and engineered recombinases and prime editing to integrate large gene-sized DNA cargoes into the mammalian genome in an efficient, precise, and targeted manner. (1/13)
https://t.co/xvjTwgApde

[Rhys Allan @rhyscienceallan]

😀😀Excited to share our new paper published @genomeresearch ! Its been a long journey and huge effort from many @WEHI_research colleagues in particular @keeeeeeeeeeenan and @HDCoughlan who studied the importance of heterochromatin for 3D genome organisation👇

[Nature Biotechnology @NatureBiotech]

Prime editing using CRISPR-Cas12a and circular RNAs in human cells https://t.co/nHo87rVwbR

[Nature Biotechnology @NatureBiotech]

A base editor is engineered for A-to-T and A-to-C transversion editing https://t.co/ogzpy6FMQK

[David R. Liu @davidrliu]

Today we report in @NatureBiotech an engineered virus-like particle system for in vivo delivery of prime editor protein-RNA complexes. This PE-eVLP platform can support therapeutic prime editing in animal models of genetic disease.
/1
https://t.co/Z3bIKF0Cyg

[TomSexton_lab @TomSexton_lab]

Out now in @PLOSBiology 👇 TLDR: Transcription CAN directly remodel TADs... in specific contexts. Big congrats to Sanjay and @yousra_zouari who spearheaded the project, and @djost_physbiol +Hossein https://t.co/EVeO0ib4Su

[Sternberg Lab @SternbergLab]

New pre-print from the Sternberg Lab! Transposon-encoded nucleases (TnpB/IscB) gave rise to the CRISPR-associated proteins (Cas9 and Cas12), but were TnpB-like proteins domesticated for other functions? 𝙔𝙀𝙎!! https://t.co/ImPdkqLaqz

[Michael Milevskiy @mjgmilevskiy]

Our #epigenetic atlas of the #mammarygland, was published yesterday. This work has highlighted how little we knew about gene regulation in normal breast cells and how much we don’t understand about #cancer formation. #cellgenomics #wehi_research https://t.co/CgnXV0GU72

[Molecular Cell @MolecularCell]

G-quadruplexes associated with R-loops promote CTCF binding https://t.co/zI6s8iGGnu

[David R. Liu @davidrliu]

Today we report in @CellCellPress a suite of engineered and PACE-evolved prime editor variants PE6a-g. These new prime editors improve the activity, in vivo deliverability, and in vivo editing efficiency of prime editing.
https://t.co/xdF6j0zn8Y
PDF:https://t.co/iRegR74CKg
(1/15)

[Nature Biotechnology @NatureBiotech]

Compact genome editors were discovered by mining a transposon library https://t.co/L4YoAn2txm

[Molecular Cell @MolecularCell]

Online Now: G-quadruplexes associated with R-loops promote CTCF binding https://t.co/fTlbKUuilk

[Nature Biotechnology @NatureBiotech]

High-efficiency transgene integration by homology-directed repair in human primary cells using DNA-PKcs inhibition https://t.co/XX6mHMspaO

[Molecular Cell @MolecularCell]

Online Now: CTCF and R-loops are boundaries of cohesin-mediated DNA looping https://t.co/wMYK1yWnmO

[Chan Wing Fuk @ChanWingFuk]

Truely grateful to receive the Emma Whitelaw ECR award ! Thank you @AEpiA for the recognition of my work !

[Australasian Epigenetics Alliance @AEpiA]

✨ ANNOUNCEMENT ✨

Congratulations to @nataliabenetti_ for winning 2nd place, and @ChanWingFuk for winning 3rd place for the Emma Whitelaw ECR Publication Award.

[David R. Liu @davidrliu]

Today we report in @NatureGenet a study led by the team of @JonathanYenPhD and Mitch Weiss @StJude that characterizes Cas9 nuclease and adenine base editing strategies to induce fetal hemoglobin expression, clinical approaches to treat sickle-cell disease & beta-thalassemia. 1/10