We are excited to be launching the next phase of our Fast & Fair peer review initiative: offering high-quality peer review within 7 working days. #fastandfairpeerreview
Read the Editorial by EiC Daniel Gorelick at: https://t.co/lcnPqovq2a
In memory of Dr. Felix Feng. Thank you @EUplatinum for honoring our beloved colleague and friend, gone too soon. We miss you Felix @MaryFengMD@nlinmd@PCF_Science
https://t.co/WOGllHwEfQ
Felix was the best of us. I'm heartbroken by his passing.💔His spirit of generosity, kindness, humility, his humor, intelligence & scientific acumen - you made us better scientists & better people, Felix. Love & miss you always. My deepest condolences to @MaryFengMD & family.🙏♥️
Genomic and epigenomic analysis of plasma cell-free DNA identifies stemness features associated with worse survival in lethal prostate cancer Out on @CCR_AACR
Study investigates metastatic castration-resistant #ProstateCancer (mCRPC) resistant to androgen receptor signaling inhibitors (ARSIs), a highly lethal form of @cancer . Using targeted and genome-wide cell-free DNA sequencing from 126 and 43 mCRPC patients, respectively, researchers found that AR/enhancer alterations in cell-free DNA🧬 prior to ARSI treatment correlated with significantly worse PFS and OS
Further analysis of the plasma methylome revealed increased promoter-level hypomethylation in patients with these alterations. Additionally, transcription factor analysis suggested that cancer lethality is driven by increased stemness. This stem-like signature was validated in a separate cohort, establishing AR/enhancer alterations as a prognostic biomarker for lethal mCRPC.
https://t.co/5U6dmAIdJ0
@pradeep198212@RBabbra@SydneyCaputo@flscientist@ChadTangMD@RPachynski@OJSartor@ChrisMaher_Lab@aadel_chaudhuri@MayoRadOnc@MayoCancerCare@MayoClinic@TulaneMedicine@MDAndersonNews
@WashUOnc
I made it! Yesterday I defended my thesis in Computational & Systems Biology at Wash U! Thank you @ChrisMaher_Lab for a fun and challenging 6-year adventure!
New in NAR Cancer. A resource to guide functional studies: a compendium of long noncoding RNAs associated with tumor, immune, or stromal cells in pancreatic cancer. From @ChrisMaher and coworkers. @WUSTL @SitemanCenter#lncrnas#bioinformatics. https://t.co/H64gsosZpa
On @medrxivpreprint!
“Genomic and epigenomic analysis of plasma cell-free DNA identifies stemness features associated with worse survival in AR-altered lethal prostate cancer”
https://t.co/8h6KoZCtsA
Kudos to @pradeep198212 & Irfan Alahi in my lab for leading the work!
Excited to share our collaborative work with Ryan Fields and Li Ding
Single-cell transcriptomics reveals long #noncoding#RNAs associated with tumor biology and the microenvironment in #pancreatic#cancer
https://t.co/3fFqaOfomZ
@WashUOnc @SitemanCenter@WUSTLmed