Christopher Maher

Professor of Internal Medicine and Biomedical Engineering @WUSTL; @WUSTLmed; @SitemanCenter; Studying #cancer #genomics #lncRNAs #bioinformatics

[Aadel Chaudhuri, MD PhD @aadel_chaudhuri]

Truly honored and grateful to be awarded the PCF Challenge Award with this incredible group of friends and collaborators + my super-⭐️ mentee @pradeep198212!

Quite the team! @AOSartor @ChrisMaher_Lab @RPachynski @JakeOrmeMDPhD @flscientist Elisa Ledet

[Biology Open @BiologyOpen]

Interested to read the ins and outs of our Fast & Fair peer review experiment? Read the preprint at https://t.co/3RNJN7ZuiM #fastandfairpeerreview

[Christopher Maher @ChrisMaher_Lab]

If you are interested in a Fast (7 days) and Fair peer review process consider this new initiative @BiologyOpen.

[Biology Open @BiologyOpen]

We are excited to be launching the next phase of our Fast & Fair peer review initiative: offering high-quality peer review within 7 working days. #fastandfairpeerreview
Read the Editorial by EiC Daniel Gorelick at: https://t.co/lcnPqovq2a

[Misha Beltran @mishabeltran]

In memory of Dr. Felix Feng. Thank you @EUplatinum for honoring our beloved colleague and friend, gone too soon. We miss you Felix @MaryFengMD @nlinmd @PCF_Science

https://t.co/WOGllHwEfQ

[Russell Pachynski @RPachynski]

Cover 🤗…congrats to the whole team! 🎉 @aadel_chaudhuri @ChrisMaher_Lab @sartor_oliver @ChadTangMD @WashUOncology @SitemanCenter @WashUDeptMed @MayoClinic @MDAndersonNews @PCF_Science @Pachynski_Lab

[Andrea Miyahira @AndreaMiyahira]

Felix was the best of us. I'm heartbroken by his passing.💔His spirit of generosity, kindness, humility, his humor, intelligence & scientific acumen - you made us better scientists & better people, Felix. Love & miss you always. My deepest condolences to @MaryFengMD & family.🙏♥️

[Prof. Nikolai Slavov @slavov_n]

The epitranscriptome formed by the growing number of modifications occurring within mRNA transcripts.

[Advanced Prostate Cancer Consensus Conference @APCCC_Lugano]

Genomic and epigenomic analysis of plasma cell-free DNA identifies stemness features associated with worse survival in lethal prostate cancer Out on @CCR_AACR

Study investigates metastatic castration-resistant #ProstateCancer (mCRPC) resistant to androgen receptor signaling inhibitors (ARSIs), a highly lethal form of @cancer . Using targeted and genome-wide cell-free DNA sequencing from 126 and 43 mCRPC patients, respectively, researchers found that AR/enhancer alterations in cell-free DNA🧬 prior to ARSI treatment correlated with significantly worse PFS and OS

Further analysis of the plasma methylome revealed increased promoter-level hypomethylation in patients with these alterations. Additionally, transcription factor analysis suggested that cancer lethality is driven by increased stemness. This stem-like signature was validated in a separate cohort, establishing AR/enhancer alterations as a prognostic biomarker for lethal mCRPC.

https://t.co/5U6dmAIdJ0

@pradeep198212
@RBabbra
@SydneyCaputo
@flscientist
@ChadTangMD
@RPachynski
@OJSartor
@ChrisMaher_Lab
@aadel_chaudhuri
@MayoRadOnc
@MayoCancerCare
@MayoClinic
@TulaneMedicine
@MDAndersonNews
@WashUOnc

[Christopher Maher @ChrisMaher_Lab]

Great collaborative effort!!! Awesome job @pradeep198212

[Aadel Chaudhuri, MD PhD @aadel_chaudhuri]

Proud of @pradeep198212 (lead scientist) + PhD student Irfan +undergrad Savar for our latest ctDNA paper @CCR_AACR on met prostate cancer!

https://t.co/7Mvo1dFLMB

@MayoRadOnc @MayoCancerCare @MayoClinic @CaltechSFP @WashUOnc @TulaneMedicine @OJSartor @RPachynski @ChrisMaher_Lab

[WashU Medicine Division of Oncology @WashUOncology]

Portrait unveiling at the conclusion of the John F DiPersio Immunotherapy Symposium
@WashUOnc @SitemanCenter @WUDeptMedicine @WUSTLmed @BarnesJewish @WUSTLdbbs @WashUDPS
#bmtsm #celltherapy #cartcells #leusm #lymsm #mmsm #mdssm

[Christopher Maher @ChrisMaher_Lab]

Congrats Dr. Zhao!!!

[Sidi Zhao Swift @sidizhao94]

I made it! Yesterday I defended my thesis in Computational & Systems Biology at Wash U! Thank you @ChrisMaher_Lab for a fun and challenging 6-year adventure!

[Christopher Maher @ChrisMaher_Lab]

Excited to share our collaborative work with @felixfengmd @David_A_Quigley using #scRNA-Seq to study the #lncRNA landscape in metastatic castration resistant #prostate #cancer

Read at npj Genomic Medicine
https://t.co/AitYzIqjcM

@WashUOnc @SitemanCenter @PCF_Science @WUSTLmed

[Christopher Maher @ChrisMaher_Lab]

@Kaochar2 @AACR @CR_AACR @BCMDeptMedicine @BCMCancerCenter Congrats!

[Christopher Maher @ChrisMaher_Lab]

@JoshLangMD @PCF_Science Congratulations Josh!

[Christopher Maher @ChrisMaher_Lab]

@ResearchWyatt @HsiehLab @piet_ost @NatureCancer @ewarner_ubc @kim_vdeecken @MurthaAj @EdmondMKwan @cherberts1 @VanProstateCtr @UBCmedicine @BCCancer_GSC @PCF_Science @VCHResearch Congrats Alex, great work!!!

[Bill Dynan - NAR Cancer Editor @NAR_Cancer_EIC]

New in NAR Cancer. A resource to guide functional studies: a compendium of long noncoding RNAs associated with tumor, immune, or stromal cells in pancreatic cancer. From @ChrisMaher and coworkers. @WUSTL @SitemanCenter #lncrnas #bioinformatics. https://t.co/H64gsosZpa

[Christopher Maher @ChrisMaher_Lab]

@HsiehLab @BellodiLab Gave a great talk @ keystone today!

[Christopher Maher @ChrisMaher_Lab]

Great to see this collaborative work with @aadel_chaudhuri and @RPachynski online now!

[Aadel Chaudhuri, MD PhD @aadel_chaudhuri]

On @medrxivpreprint!

“Genomic and epigenomic analysis of plasma cell-free DNA identifies stemness features associated with worse survival in AR-altered lethal prostate cancer”

https://t.co/8h6KoZCtsA

Kudos to @pradeep198212 & Irfan Alahi in my lab for leading the work!

[Christopher Maher @ChrisMaher_Lab]

@winhide Have a collaborator needing to do just this!

[Christopher Maher @ChrisMaher_Lab]

Excited to share our collaborative work with Ryan Fields and Li Ding

Single-cell transcriptomics reveals long #noncoding #RNAs associated with tumor biology and the microenvironment in #pancreatic #cancer

https://t.co/3fFqaOfomZ

@WashUOnc @SitemanCenter @WUSTLmed