Very excited to release Sequoia, our pipeline for phylogenetic tree reconstruction from mutations in normal cells. A detailed description is now published in @NatureProtocols! https://t.co/aXH8ZIjA3C
Thrilled to welcome @JavierHerrero7 as the Project Director of Bioinformatics at @AsgardThx. With 25 years of expertise, Javier will play a key role in identifying genetic and epigenetic factors for reprogramming and treatment efficacy.🌟
Welcome to the team, Javier!
From @Nature - Why we need an academic career path that combines science and art: https://t.co/auyrivkWIK
A thought provoking discussion on the relationship between science and art. The science-art dichotomy has always seemed arbitrary to me
CONIPHER, our method for automated reconstruction of tumour subclonal structure and phylogeny that we used in our recently published TRACERx studies, is now out in Nature Protocols! (https://t.co/MObIlTZf6D). Welcome to the CONIPHER TREEtorial, just in time for Christmas! 🌲 1/n
Excited to share the first preprint of my PhD @sangerinstitute looking into the prevalence and genetic mechanisms of gene misexpression in 4,568 whole blood RNA-seq samples from the INTERVAL cohort. https://t.co/5Ia0Z1YVPR
Our latest paper: measurement of cancer evolutionary dynamics at massive scale, using just a methylation array on bulk DNA. Find evolutionary dynamics strongly determine clinical outcomes in lymphoid cancers. Fab collab with Inaki Martin & @Marti_DF, & led by @CalumGabbutt. A🧵⬇️
Can everyone please congratulate Dr @ChulingD on being awarded her #PhD in Cancer Genomics?
Inquisitive, systematic and driven, this PhD is so well deserved. Congrats Chuling!
@uclcancer@uclmedsci
Very excited to see our study on a case of ALL to AML switch after CAR-T treatment out in @NatureCancer! Using deep genome sequencing, we show the cancer switched cell types to escape therapy.
@broadinstitute@sangerinstitute@getz_lab
Thread below 🧵
https://t.co/LGUtJmZ7O2
Excited to announce our new method HATCHet2 for inferring haplotype- and clone-specific copy number from bulk samples! HATCHet2 extends HATCHet to infer mirrored-subclonal CNAs, and introduces new binning and clustering approaches.
https://t.co/AaccVcauCE
June really appears to be my lucky month - our new preprint is out on @researchsquare! 😍 Together with @doctor_msc, @andrewrjlawson and many others we looked into the life history of mitochondria in the human haematopoietic system https://t.co/7qjyALrJ65. [1/x]
Can ctDNA can be harnessed to identify ongoing karyotype evolution and heterogeneity in pancreatic cancer? Great work from @jrm_black@AMIHuebner …thread👇